Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome

Detalhes bibliográficos
Autor(a) principal: Goncalves, Marilda S.
Data de Publicação: 2011
Outros Autores: Cerqueira, Bruno A. V., Vilas Boas, Wendell, Zanette, Angela Maria Dias, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16553
Resumo: Texto completo: acesso restrito. p. 471–476
id UFBA-2_393ed6d7538729d9c44400abee67c1cb
oai_identifier_str oai:repositorio.ufba.br:ri/16553
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Goncalves, Marilda S.Cerqueira, Bruno A. V.Vilas Boas, WendellZanette, Angela Maria DiasReis, Mitermayer Galvão dosGoncalves, Marilda S.Cerqueira, Bruno A. V.Vilas Boas, WendellZanette, Angela Maria DiasReis, Mitermayer Galvão dos2014-11-11T17:59:44Z20111043-4666http://repositorio.ufba.br/ri/handle/ri/16553v. 56, n. 2Texto completo: acesso restrito. p. 471–476Sickle cell anemia (SCA) is a common, severe monogenetic disorder characterized by chronic hemolysis, frequent infections, a chronic inflammatory state and recurrent occlusions of the microcirculation, resulting in painful crises, organ damage and premature death. This study evaluated associations between serum levels of IL-18, uric acid, hemolytic markers, and inflammatory molecules in SCA patients. A cross-sectional study was performed including 45 SCA patients (median age of 20.5 years) without general symptoms and who had not undergone blood transfusions. Inclusion criteria for the steady-state SCA patients were the absence of hospitalization and the absence of infections. Interleukin-18 and uric acid levels were correlated closely with markers of hemolysis, endothelial dysfunction and others cytokines levels. These findings suggest probable influences of IL-18 and uric acid in the pathophysiology of vascular occlusion in SCA. Additional studies should be performed to characterize similar prognosis markers and possible therapeutic targets.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-02T16:24:33Z No. of bitstreams: 1 Marilda S. Goncalves.pdf: 606228 bytes, checksum: 51f2953418584ad1cbfdf12fa03d208b (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-11-11T17:59:44Z (GMT) No. of bitstreams: 1 Marilda S. Goncalves.pdf: 606228 bytes, checksum: 51f2953418584ad1cbfdf12fa03d208b (MD5)Made available in DSpace on 2014-11-11T17:59:44Z (GMT). No. of bitstreams: 1 Marilda S. Goncalves.pdf: 606228 bytes, checksum: 51f2953418584ad1cbfdf12fa03d208b (MD5) Previous issue date: 2011http://dx.doi.org/10.1016/j.cyto.2011.08.013reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASickle cell anemiaCytokineInflammationIncreased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasomeCytokineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALMarilda S. Goncalves.pdfMarilda S. Goncalves.pdfapplication/pdf606228https://repositorio.ufba.br/bitstream/ri/16553/1/Marilda%20S.%20Goncalves.pdf51f2953418584ad1cbfdf12fa03d208bMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16553/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTMarilda S. Goncalves.pdf.txtMarilda S. Goncalves.pdf.txtExtracted texttext/plain30466https://repositorio.ufba.br/bitstream/ri/16553/3/Marilda%20S.%20Goncalves.pdf.txtf80abfc1e053ebe1e90832e6e3ba4adfMD53ri/165532022-07-05 14:03:21.616oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
dc.title.alternative.pt_BR.fl_str_mv Cytokine
title Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
spellingShingle Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
Goncalves, Marilda S.
Sickle cell anemia
Cytokine
Inflammation
title_short Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_full Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_fullStr Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_full_unstemmed Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
title_sort Increased concentrations of IL-18 and uric acid in sickle cell anemia: Contribution of hemolysis, endothelial activation and the inflammasome
author Goncalves, Marilda S.
author_facet Goncalves, Marilda S.
Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
author_role author
author2 Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Goncalves, Marilda S.
Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Goncalves, Marilda S.
Cerqueira, Bruno A. V.
Vilas Boas, Wendell
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
dc.subject.por.fl_str_mv Sickle cell anemia
Cytokine
Inflammation
topic Sickle cell anemia
Cytokine
Inflammation
description Texto completo: acesso restrito. p. 471–476
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-11-11T17:59:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16553
dc.identifier.issn.none.fl_str_mv 1043-4666
dc.identifier.number.pt_BR.fl_str_mv v. 56, n. 2
identifier_str_mv 1043-4666
v. 56, n. 2
url http://repositorio.ufba.br/ri/handle/ri/16553
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.cyto.2011.08.013
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/16553/1/Marilda%20S.%20Goncalves.pdf
https://repositorio.ufba.br/bitstream/ri/16553/2/license.txt
https://repositorio.ufba.br/bitstream/ri/16553/3/Marilda%20S.%20Goncalves.pdf.txt
bitstream.checksum.fl_str_mv 51f2953418584ad1cbfdf12fa03d208b
0d4b811ef71182510d2015daa7c8a900
f80abfc1e053ebe1e90832e6e3ba4adf
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459472276815872

Registros relacionados