Model of induction of thyroid dysfunctions in adult female mice
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5349 |
Resumo: | It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed. |
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Ferreira, E.Lima, Alessandra Estrela da SilvaSerakides, R.Gomes, A. S.Cassali, Geovanni DantasFerreira, E.Lima, Alessandra Estrela da SilvaSerakides, R.Gomes, A. S.Cassali, Geovanni Dantas2012-02-08T21:39:39Z2012-02-08T21:39:39Z20070102-0935http://www.repositorio.ufba.br/ri/handle/ri/5349v. 59, n. 5It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-08T21:39:39Z No. of bitstreams: 1 a22v59n5.pdf: 795018 bytes, checksum: 7429ccc221f10d21b0135ce1e811ce4b (MD5)Made available in DSpace on 2012-02-08T21:39:39Z (GMT). No. of bitstreams: 1 a22v59n5.pdf: 795018 bytes, checksum: 7429ccc221f10d21b0135ce1e811ce4b (MD5) Previous issue date: 2007-10http://www.scielo.br/pdf/abmvz/v59n5/a22v59n5.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAmousethyroidprotocolinductionthyroxinpropylthiouracilModel of induction of thyroid dysfunctions in adult female miceArq. Bras. Med. Vet. Zootecinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALa22v59n5.pdfa22v59n5.pdfapplication/pdf795018https://repositorio.ufba.br/bitstream/ri/5349/1/a22v59n5.pdf7429ccc221f10d21b0135ce1e811ce4bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5349/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTa22v59n5.pdf.txta22v59n5.pdf.txtExtracted texttext/plain16184https://repositorio.ufba.br/bitstream/ri/5349/3/a22v59n5.pdf.txt1c6c1e2ec40672bce184c10563d7f866MD53ri/53492022-10-04 13:37:19.955oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-04T16:37:19Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Model of induction of thyroid dysfunctions in adult female mice |
dc.title.alternative.pt_BR.fl_str_mv |
Arq. Bras. Med. Vet. Zootec |
title |
Model of induction of thyroid dysfunctions in adult female mice |
spellingShingle |
Model of induction of thyroid dysfunctions in adult female mice Ferreira, E. mouse thyroid protocol induction thyroxin propylthiouracil |
title_short |
Model of induction of thyroid dysfunctions in adult female mice |
title_full |
Model of induction of thyroid dysfunctions in adult female mice |
title_fullStr |
Model of induction of thyroid dysfunctions in adult female mice |
title_full_unstemmed |
Model of induction of thyroid dysfunctions in adult female mice |
title_sort |
Model of induction of thyroid dysfunctions in adult female mice |
author |
Ferreira, E. |
author_facet |
Ferreira, E. Lima, Alessandra Estrela da Silva Serakides, R. Gomes, A. S. Cassali, Geovanni Dantas |
author_role |
author |
author2 |
Lima, Alessandra Estrela da Silva Serakides, R. Gomes, A. S. Cassali, Geovanni Dantas |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, E. Lima, Alessandra Estrela da Silva Serakides, R. Gomes, A. S. Cassali, Geovanni Dantas Ferreira, E. Lima, Alessandra Estrela da Silva Serakides, R. Gomes, A. S. Cassali, Geovanni Dantas |
dc.subject.por.fl_str_mv |
mouse thyroid protocol induction thyroxin propylthiouracil |
topic |
mouse thyroid protocol induction thyroxin propylthiouracil |
description |
It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2012-02-08T21:39:39Z |
dc.date.available.fl_str_mv |
2012-02-08T21:39:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5349 |
dc.identifier.issn.none.fl_str_mv |
0102-0935 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 59, n. 5 |
identifier_str_mv |
0102-0935 v. 59, n. 5 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/5349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.pt_BR.fl_str_mv |
http://www.scielo.br/pdf/abmvz/v59n5/a22v59n5.pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
instname_str |
Universidade Federal da Bahia (UFBA) |
instacron_str |
UFBA |
institution |
UFBA |
reponame_str |
Repositório Institucional da UFBA |
collection |
Repositório Institucional da UFBA |
bitstream.url.fl_str_mv |
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