Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7963 |
Resumo: | Texto completo: acesso restrito. p.61–67 |
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Coutinho, Elsimar MetzkerAthayde, Célia Maria SoaresAtta, GabrielEmuveyan, Edward E.Adekunle, Adeyemi O.Mati, JaphethOtubu, JosephCoutinho, Elsimar MetzkerAthayde, Célia Maria SoaresAtta, GabrielEmuveyan, Edward E.Adekunle, Adeyemi O.Mati, JaphethOtubu, Joseph2013-01-17T10:32:43Z20000010-7824http://www.repositorio.ufba.br/ri/handle/ri/7963v. 61, n. 1Texto completo: acesso restrito. p.61–67The safety and efficacy of gossypol continues to be controversial. The aim of this study was to evaluate gossypol as a contraceptive pill for men at doses lower than those previously prescribed and in men from various ethnic origin. A total of 151 men from Brazil, Nigeria, Kenya, and China were divided into two groups. Both groups received 15 mg gossypol/day for 12 or 16 weeks to reach spermatogenesis suppression. Subjects were then randomized to either 7.5 or 10 mg/day for 40 weeks. In addition, 51 men were enrolled as a control group. In all, 81 subjects attained spermatogenesis suppression. Only one man discontinued treatment because of tiredness. Potassium levels fluctuated within the normal range. FSH increased consistently. Testicular volume decreased, but after discontinuation, values returned to levels not statistically different from admission. Of 19 subjects on the 7.5 mg/day dose group, 12 recovered sperm counts >20 million/mL within 12 months of discontinuing gossypol. In the 10 mg/day group, sperm counts recovered in only 10 of 24 subjects. Eight of the 43 patients remained azoospermic 1 year after stopping gossypol. All men diagnosed with varicocele failed to reverse spermatogenesis suppression. Gossypol blood levels indicated that sperm suppression occurs independently of concentration, whereas spermatogenesis recovery appears to be concentration-dependent. Gossypol may become a medical alternative to surgical vasectomy when the delay in onset of infertility is acceptable. When taken for 1 year, gossypol causes no reduction in sexual desire or frequency of intercourse. The possibility of reversal, occurring in 51% of the men on this regimen within 1 year after stopping gossypol, is an advantage of this compound as compared with surgical sterilization in many parts of the world.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-17T10:32:43Z No. of bitstreams: 1 Coutinho.pdf: 219157 bytes, checksum: e708c6776a6441975fa360f67ee9316b (MD5)Made available in DSpace on 2013-01-17T10:32:43Z (GMT). No. of bitstreams: 1 Coutinho.pdf: 219157 bytes, checksum: e708c6776a6441975fa360f67ee9316b (MD5) Previous issue date: 2000http://dx.doi.org/10.1016/S0010-7824(99)00117-1reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAgossypolspermatogenesis suppressionreversibilityplasma gossypol levelspotassium levelsGossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding studyContraceptioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALCoutinho.pdfCoutinho.pdfapplication/pdf219157https://repositorio.ufba.br/bitstream/ri/7963/1/Coutinho.pdfe708c6776a6441975fa360f67ee9316bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7963/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTCoutinho.pdf.txtCoutinho.pdf.txtExtracted texttext/plain29434https://repositorio.ufba.br/bitstream/ri/7963/3/Coutinho.pdf.txtf808101a48726d14c5fdb1d4925a690dMD53ri/79632022-07-05 14:03:20.495oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
dc.title.alternative.pt_BR.fl_str_mv |
Contraception |
title |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
spellingShingle |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study Coutinho, Elsimar Metzker gossypol spermatogenesis suppression reversibility plasma gossypol levels potassium levels |
title_short |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
title_full |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
title_fullStr |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
title_full_unstemmed |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
title_sort |
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive: A multicenter, international, dose-finding study |
author |
Coutinho, Elsimar Metzker |
author_facet |
Coutinho, Elsimar Metzker Athayde, Célia Maria Soares Atta, Gabriel Emuveyan, Edward E. Adekunle, Adeyemi O. Mati, Japheth Otubu, Joseph |
author_role |
author |
author2 |
Athayde, Célia Maria Soares Atta, Gabriel Emuveyan, Edward E. Adekunle, Adeyemi O. Mati, Japheth Otubu, Joseph |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Coutinho, Elsimar Metzker Athayde, Célia Maria Soares Atta, Gabriel Emuveyan, Edward E. Adekunle, Adeyemi O. Mati, Japheth Otubu, Joseph Coutinho, Elsimar Metzker Athayde, Célia Maria Soares Atta, Gabriel Emuveyan, Edward E. Adekunle, Adeyemi O. Mati, Japheth Otubu, Joseph |
dc.subject.por.fl_str_mv |
gossypol spermatogenesis suppression reversibility plasma gossypol levels potassium levels |
topic |
gossypol spermatogenesis suppression reversibility plasma gossypol levels potassium levels |
description |
Texto completo: acesso restrito. p.61–67 |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2013-01-17T10:32:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/7963 |
dc.identifier.issn.none.fl_str_mv |
0010-7824 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 61, n. 1 |
identifier_str_mv |
0010-7824 v. 61, n. 1 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/7963 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1016/S0010-7824(99)00117-1 |
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