Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies

Detalhes bibliográficos
Autor(a) principal: Schmidt, Wolf Peter
Data de Publicação: 2010
Outros Autores: Boisson, Sophie, Genser, Bernd, Barreto, Mauricio Lima, Baisley, Kathy, Filteau, Suzanne, Cairncross, Sandy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/11993
Resumo: Texto completo: acesso restrito. p.1074-1079
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spelling Schmidt, Wolf PeterBoisson, SophieGenser, BerndBarreto, Mauricio LimaBaisley, KathyFilteau, SuzanneCairncross, SandySchmidt, Wolf PeterBoisson, SophieGenser, BerndBarreto, Mauricio LimaBaisley, KathyFilteau, SuzanneCairncross, Sandy2013-06-19T12:22:58Z20100143-005Xhttp://www.repositorio.ufba.br/ri/handle/ri/11993v. 64, n. 12Texto completo: acesso restrito. p.1074-1079Background The validity of unblinded randomised trials testing interventions against diarrhoea is severely compromised by the potential for bias. Objective proxy markers for diarrhoea not relying on self-report are needed to assess the effect of interventions that cannot be blinded. Short-term changes in weight-for-age z-score (WAZ) may (due to catch-up growth) not be a clinically important marker for nutritional status. However, even a transient decrease in WAZ could indicate recent diarrhoea, and be interpreted as the effect of an intervention. Methods Using data from two large vitamin A trials from Ghana and Brazil, the immediate effect of the cumulative diarrhoea occurrence over 14 and 28 day time windows on WAZ was explored. Results A very strong linear association was found between the number of days with diarrhoea over the last 14–28 days and WAZ. In both trials, differences in diarrhoea between the trial arms were associated with corresponding differences in WAZ. Conclusion Repeated WAZ measures appear to be a suitable proxy marker for diarrhoea in children, but have disadvantages in terms of specificity and study power.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-06-19T12:22:58Z No. of bitstreams: 1 Wolf-Peter Schmidt.pdf: 230722 bytes, checksum: e7ab6ae532893af51f780c3c1d4f23ed (MD5)Made available in DSpace on 2013-06-19T12:22:58Z (GMT). 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dc.title.pt_BR.fl_str_mv Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
dc.title.alternative.pt_BR.fl_str_mv Journal of Epidemiology and Community Health
title Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
spellingShingle Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
Schmidt, Wolf Peter
title_short Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
title_full Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
title_fullStr Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
title_full_unstemmed Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
title_sort Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies
author Schmidt, Wolf Peter
author_facet Schmidt, Wolf Peter
Boisson, Sophie
Genser, Bernd
Barreto, Mauricio Lima
Baisley, Kathy
Filteau, Suzanne
Cairncross, Sandy
author_role author
author2 Boisson, Sophie
Genser, Bernd
Barreto, Mauricio Lima
Baisley, Kathy
Filteau, Suzanne
Cairncross, Sandy
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schmidt, Wolf Peter
Boisson, Sophie
Genser, Bernd
Barreto, Mauricio Lima
Baisley, Kathy
Filteau, Suzanne
Cairncross, Sandy
Schmidt, Wolf Peter
Boisson, Sophie
Genser, Bernd
Barreto, Mauricio Lima
Baisley, Kathy
Filteau, Suzanne
Cairncross, Sandy
description Texto completo: acesso restrito. p.1074-1079
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-06-19T12:22:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/11993
dc.identifier.issn.none.fl_str_mv 0143-005X
dc.identifier.number.pt_BR.fl_str_mv v. 64, n. 12
identifier_str_mv 0143-005X
v. 64, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/11993
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1136/jech.2009.099721
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instname:Universidade Federal da Bahia (UFBA)
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