Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Unger, A.
Data de Publicação: 2009
Outros Autores: O'Neal, S., Machado, Paulo Roberto Lima, Guimarães, L. H., Morgan, D. J., Schriefer, Nicolaus Albert Borges, Bacellar, Maria Olívia Amado Ramos, Glesby, M. J., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13722
Resumo: Texto completo: acesso restrito. p.574-579
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spelling Unger, A.O'Neal, S.Machado, Paulo Roberto LimaGuimarães, L. H.Morgan, D. J.Schriefer, Nicolaus Albert BorgesBacellar, Maria Olívia Amado RamosGlesby, M. J.Carvalho Filho, Edgar Marcelino deUnger, A.O'Neal, S.Machado, Paulo Roberto LimaGuimarães, L. H.Morgan, D. J.Schriefer, Nicolaus Albert BorgesBacellar, Maria Olívia Amado RamosGlesby, M. J.Carvalho Filho, Edgar Marcelino de2013-11-18T21:16:17Z20090002-9637http://repositorio.ufba.br/ri/handle/ri/13722v. 80, n. 4Texto completo: acesso restrito. p.574-579Cure rates for American cutaneous leishmaniasis (ACL) range between 60% and 90%. Early evidence suggests lower cure rates for early ACL before the development of the ulceration. We evaluated risk factors for treatment failure in patients with early and classic ulcerative ACL. Patients (n = 136) were 13-60 years of age and had lesions with a duration of 15-90-days. Patients were treated with antimony (20 mg/kg/day for 20 days). The primary outcome was lesion cure by 90 days without recurrence. Patients with early ACL (n = 16) had papules, nodules, plaques, or superficial ulcerations with less than 30 days of illness. Patients with classic ulcerative ACL (n = 120) had ulcerated classic lesions, longer duration, larger lesions, and higher levels of interferon-γ and tumor necrosis factor-α (P < 0.01 for all comparisons). Ulcerated lesions were associated with a lower treatment failure rate compared with early ACL (25.8% versus 75.0%; P < 0.001). Early treatment of ACL does not prevent lesion ulceration and is associated with higher rates of treatment failure. 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dc.title.pt_BR.fl_str_mv Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
dc.title.alternative.pt_BR.fl_str_mv American Journal of Tropical Medicine and Hygiene
title Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
spellingShingle Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
Unger, A.
title_short Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
title_full Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
title_fullStr Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
title_full_unstemmed Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
title_sort Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil
author Unger, A.
author_facet Unger, A.
O'Neal, S.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Morgan, D. J.
Schriefer, Nicolaus Albert Borges
Bacellar, Maria Olívia Amado Ramos
Glesby, M. J.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 O'Neal, S.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Morgan, D. J.
Schriefer, Nicolaus Albert Borges
Bacellar, Maria Olívia Amado Ramos
Glesby, M. J.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Unger, A.
O'Neal, S.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Morgan, D. J.
Schriefer, Nicolaus Albert Borges
Bacellar, Maria Olívia Amado Ramos
Glesby, M. J.
Carvalho Filho, Edgar Marcelino de
Unger, A.
O'Neal, S.
Machado, Paulo Roberto Lima
Guimarães, L. H.
Morgan, D. J.
Schriefer, Nicolaus Albert Borges
Bacellar, Maria Olívia Amado Ramos
Glesby, M. J.
Carvalho Filho, Edgar Marcelino de
description Texto completo: acesso restrito. p.574-579
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-11-18T21:16:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13722
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.number.pt_BR.fl_str_mv v. 80, n. 4
identifier_str_mv 0002-9637
v. 80, n. 4
url http://repositorio.ufba.br/ri/handle/ri/13722
dc.language.iso.fl_str_mv eng
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