Between the cross and the sword: the crisis of the gene concept

Detalhes bibliográficos
Autor(a) principal: El-Hani, Charbel Niño
Data de Publicação: 2007
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2620
Resumo: p.297-307
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spelling El-Hani, Charbel NiñoEl-Hani, Charbel Niño2011-09-08T19:17:51Z2011-09-08T19:17:51Z2007-031415-4757http://www.repositorio.ufba.br/ri/handle/ri/262030(2):297-307p.297-307Challenges to the gene concept have shown the difficulty of preserving the classical molecular concept, according to which a gene is a stretch of DNA encoding a functional product (polypeptide or RNA). The main difficulties are related to the overlaying of the Mendelian idea of the gene as a unit : the interpretation of genes as structural and/or functional units in the genome is challenged by evidence showing the complexity and diversity of genomic organization. This paper discusses the difficulties faced by the classical molecular concept and addresses alternatives to it. Among the alternatives, it considers distinctions between different gene concepts, such as that between the molecular and the evolutionary gene, or between gene-P (the gene as determinant of phenotypic differences) and gene-D (the gene as developmental resource). It also addresses the process molecular gene concept, according to which genes are understood as the whole molecular process underlying the capacity to express a particular product, rather than as entities in bare DNA; a treatment of genes as sets of domains (exons, introns, promoters, enhancers, etc.) in DNA; and a systemic understanding of genes as combinations of nucleic acid sequences corresponding to a product specified or demarcated by the cellular system. In all these cases, possible contributions to the advancement of our understanding of the architecture and dynamics of the genetic material are emphasized.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-09-08T19:17:51Z No. of bitstreams: 1 a01v30n2.pdf: 112973 bytes, checksum: 84b6bef03fd3296148d6a3211c786da1 (MD5)Made available in DSpace on 2011-09-08T19:17:51Z (GMT). No. of bitstreams: 1 a01v30n2.pdf: 112973 bytes, checksum: 84b6bef03fd3296148d6a3211c786da1 (MD5) Previous issue date: 2007-03São Paulogeneclassical molecular gene conceptMendelian genegenomic complexityBetween the cross and the sword: the crisis of the gene conceptGenetics and Molecular Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALa01v30n2.pdfa01v30n2.pdfapplication/pdf112973https://repositorio.ufba.br/bitstream/ri/2620/1/a01v30n2.pdf84b6bef03fd3296148d6a3211c786da1MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2620/2/license.txtb457d1390cf5b854b8ec150269692799MD52TEXTa01v30n2.pdf.txta01v30n2.pdf.txtExtracted texttext/plain59397https://repositorio.ufba.br/bitstream/ri/2620/3/a01v30n2.pdf.txtb2168fd587344691dbf0e48ef8ef8bc1MD53ri/26202022-07-05 14:03:09.366oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:09Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Between the cross and the sword: the crisis of the gene concept
dc.title.alternative.pt_BR.fl_str_mv Genetics and Molecular Biology
title Between the cross and the sword: the crisis of the gene concept
spellingShingle Between the cross and the sword: the crisis of the gene concept
El-Hani, Charbel Niño
gene
classical molecular gene concept
Mendelian gene
genomic complexity
title_short Between the cross and the sword: the crisis of the gene concept
title_full Between the cross and the sword: the crisis of the gene concept
title_fullStr Between the cross and the sword: the crisis of the gene concept
title_full_unstemmed Between the cross and the sword: the crisis of the gene concept
title_sort Between the cross and the sword: the crisis of the gene concept
author El-Hani, Charbel Niño
author_facet El-Hani, Charbel Niño
author_role author
dc.contributor.author.fl_str_mv El-Hani, Charbel Niño
El-Hani, Charbel Niño
dc.subject.por.fl_str_mv gene
classical molecular gene concept
Mendelian gene
genomic complexity
topic gene
classical molecular gene concept
Mendelian gene
genomic complexity
description p.297-307
publishDate 2007
dc.date.issued.fl_str_mv 2007-03
dc.date.accessioned.fl_str_mv 2011-09-08T19:17:51Z
dc.date.available.fl_str_mv 2011-09-08T19:17:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2620
dc.identifier.issn.none.fl_str_mv 1415-4757
dc.identifier.number.pt_BR.fl_str_mv 30(2):297-307
identifier_str_mv 1415-4757
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url http://www.repositorio.ufba.br/ri/handle/ri/2620
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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