Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5650 |
Resumo: | p. 1-9. |
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Seixas, Magda OliveiraRocha, Larissa C.Carvalho, Mauricio B.Menezes, Joelma FigueiredoLyra, Isa MenezesNascimento, Valma M. L.Couto, Ricardo DavidAtta, Ajax MercêsReis, Mitermayer G.Goncalves, Marilda S.Seixas, Magda OliveiraRocha, Larissa C.Carvalho, Mauricio B.Menezes, Joelma FigueiredoLyra, Isa MenezesNascimento, Valma M. L.Couto, Ricardo DavidAtta, Ajax MercêsReis, Mitermayer G.Goncalves, Marilda S.2012-04-19T13:06:48Z2012-04-19T13:06:48Z20101476-511Xhttp://www.repositorio.ufba.br/ri/handle/ri/5650v. 9 n. 9.p. 1-9.Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up.We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steadystate children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. Methods: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter respectively. Clinical data were collected from patient medical records. Results: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005), bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001), aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol (P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of cholelithiasis. Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers, including those related to inflammation. This represents an important step toward a more reliable clinical prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this complex network of markers and their role in SCD pathogenesis.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-19T13:06:48Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf: 223149 bytes, checksum: 4d0409861f587c25482b8f603787d683 (MD5)Made available in DSpace on 2012-04-19T13:06:48Z (GMT). No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf: 223149 bytes, checksum: 4d0409861f587c25482b8f603787d683 (MD5) Previous issue date: 2010DOI: 10.1186/1476-511X-9-91reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALevels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell diseaseLipids in Health and Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5650/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdfC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdfapplication/pdf223149https://repositorio.ufba.br/bitstream/ri/5650/1/C__Documents%20and%20Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf4d0409861f587c25482b8f603787d683MD51TEXTC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtC__Documents and Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtExtracted texttext/plain37600https://repositorio.ufba.br/bitstream/ri/5650/3/C__Documents%20and%20Settings_rep...t.default_Cache_4_2A_BC3C6d01.pdf.txtf835170fedd6885d7426441caaa255a4MD53ri/56502022-07-05 14:03:21.847oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
dc.title.alternative.pt_BR.fl_str_mv |
Lipids in Health and Disease |
title |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
spellingShingle |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease Seixas, Magda Oliveira |
title_short |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
title_full |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
title_fullStr |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
title_full_unstemmed |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
title_sort |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
author |
Seixas, Magda Oliveira |
author_facet |
Seixas, Magda Oliveira Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. |
author_role |
author |
author2 |
Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Seixas, Magda Oliveira Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. Seixas, Magda Oliveira Rocha, Larissa C. Carvalho, Mauricio B. Menezes, Joelma Figueiredo Lyra, Isa Menezes Nascimento, Valma M. L. Couto, Ricardo David Atta, Ajax Mercês Reis, Mitermayer G. Goncalves, Marilda S. |
description |
p. 1-9. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2012-04-19T13:06:48Z |
dc.date.available.fl_str_mv |
2012-04-19T13:06:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5650 |
dc.identifier.issn.none.fl_str_mv |
1476-511X |
dc.identifier.number.pt_BR.fl_str_mv |
v. 9 n. 9. |
identifier_str_mv |
1476-511X v. 9 n. 9. |
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http://www.repositorio.ufba.br/ri/handle/ri/5650 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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DOI: 10.1186/1476-511X-9-91 |
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UFBA |
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Repositório Institucional da UFBA |
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