Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13373 |
Resumo: | Texto completo: acesso restrito. p.7853–7859 |
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Schriefer, Nicolaus Albert BorgesMachado, Paulo Roberto LimaLessa, Hélio AndradeCarvalho, Lucas Pedreira deJesus, Amélia Maria Ribeiro deCarvalho Filho, Edgar Marcelino deFaria, Daniela R.Gollob, Kenneth JohnBarbosa Junior, JoséRomano-Silva, Marco AurélioDutra, Walderez OrnelasSchriefer, Nicolaus Albert BorgesMachado, Paulo Roberto LimaLessa, Hélio AndradeCarvalho, Lucas Pedreira deJesus, Amélia Maria Ribeiro deCarvalho Filho, Edgar Marcelino deFaria, Daniela R.Gollob, Kenneth JohnBarbosa Junior, JoséRomano-Silva, Marco AurélioDutra, Walderez Ornelas2013-10-30T20:14:43Z20050019-9567http://repositorio.ufba.br/ri/handle/ri/13373v.73 n. 12Texto completo: acesso restrito. p.7853–7859Human infection with Leishmania braziliensis can lead to cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML). We hypothesize that the intense tissue destruction observed in ML is a consequence of an uncontrolled exacerbated inflammatory immune response, with cytotoxic activity. For the first time, this work identifies the cellular sources of inflammatory and antiinflammatory cytokines, the expression of effector molecules, and the expression of interleukin-10 (IL-10) receptor in ML and CL lesions by using confocal microscopy. ML lesions displayed a higher number of gamma interferon (IFN-γ)-producing cells than did CL lesions. In both ML and CL, CD4+ cells represented the majority of IFN-γ-producing cells, followed by CD8+ cells and CD4− CD8− cells. The numbers of tumor necrosis factor alpha-positive cells, as well as those of IL-10-producing cells, were similar in ML and CL lesions. The effector molecule granzyme A showed greater expression in ML than in CL lesions, while inducible nitric oxide synthase did not. Finally, the expression of IL-10 receptor was lower in ML than in CL lesions. Thus, our data identified distinct cytokine and cell population profiles for CL versus ML patients and provide a possible mechanism for the development of ML disease through the demonstration that low expression of IL-10 receptor is present in conjunction with a cytotoxic and inflammatory profile in ML.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-10-29T10:55:24Z No. of bitstreams: 1 Albert Schriefer.pdf: 746203 bytes, checksum: 8d13bce42d07a5481cae464f49be1ee5 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2013-10-30T20:14:43Z (GMT) No. of bitstreams: 1 Albert Schriefer.pdf: 746203 bytes, checksum: 8d13bce42d07a5481cae464f49be1ee5 (MD5)Made available in DSpace on 2013-10-30T20:14:43Z (GMT). No. of bitstreams: 1 Albert Schriefer.pdf: 746203 bytes, checksum: 8d13bce42d07a5481cae464f49be1ee5 (MD5) Previous issue date: 2005http://dx.doi.org/ 10.1128/IAI.73.12.7853-7859.2005reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasis, CutaneousInfectioninflammatory immune responseDecreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal LeishmaniasisInfection and Immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALAlbert Schriefer.pdfAlbert Schriefer.pdfapplication/pdf746203https://repositorio.ufba.br/bitstream/ri/13373/1/Albert%20Schriefer.pdf8d13bce42d07a5481cae464f49be1ee5MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13373/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAlbert Schriefer.pdf.txtAlbert Schriefer.pdf.txtExtracted texttext/plain44360https://repositorio.ufba.br/bitstream/ri/13373/3/Albert%20Schriefer.pdf.txt47802f549fac610be4b3d5321e01e9baMD53ri/133732022-07-05 14:03:28.655oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
Infection and Immunity |
| title |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| spellingShingle |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis Schriefer, Nicolaus Albert Borges Leishmaniasis, Cutaneous Infection inflammatory immune response |
| title_short |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| title_full |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| title_fullStr |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| title_full_unstemmed |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| title_sort |
Decreased In Situ Expression of Interleukin-10 Receptor Is Correlated with the Exacerbated Inflammatory and Cytotoxic Responses Observed in Mucosal Leishmaniasis |
| author |
Schriefer, Nicolaus Albert Borges |
| author_facet |
Schriefer, Nicolaus Albert Borges Machado, Paulo Roberto Lima Lessa, Hélio Andrade Carvalho, Lucas Pedreira de Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de Faria, Daniela R. Gollob, Kenneth John Barbosa Junior, José Romano-Silva, Marco Aurélio Dutra, Walderez Ornelas |
| author_role |
author |
| author2 |
Machado, Paulo Roberto Lima Lessa, Hélio Andrade Carvalho, Lucas Pedreira de Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de Faria, Daniela R. Gollob, Kenneth John Barbosa Junior, José Romano-Silva, Marco Aurélio Dutra, Walderez Ornelas |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Schriefer, Nicolaus Albert Borges Machado, Paulo Roberto Lima Lessa, Hélio Andrade Carvalho, Lucas Pedreira de Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de Faria, Daniela R. Gollob, Kenneth John Barbosa Junior, José Romano-Silva, Marco Aurélio Dutra, Walderez Ornelas Schriefer, Nicolaus Albert Borges Machado, Paulo Roberto Lima Lessa, Hélio Andrade Carvalho, Lucas Pedreira de Jesus, Amélia Maria Ribeiro de Carvalho Filho, Edgar Marcelino de Faria, Daniela R. Gollob, Kenneth John Barbosa Junior, José Romano-Silva, Marco Aurélio Dutra, Walderez Ornelas |
| dc.subject.por.fl_str_mv |
Leishmaniasis, Cutaneous Infection inflammatory immune response |
| topic |
Leishmaniasis, Cutaneous Infection inflammatory immune response |
| description |
Texto completo: acesso restrito. p.7853–7859 |
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2005 |
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2005 |
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2013-10-30T20:14:43Z |
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0019-9567 |
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v.73 n. 12 |
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0019-9567 v.73 n. 12 |
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