A genome-wide association study of asthma symptoms in Latin American children
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/19061 |
Resumo: | Background: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. Methods: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC)questionnaire. Following quality control, 1 877 526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an stimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. Results: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95 % CI 1.45–2.18, p-value 2.83 × 10−8)and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95 % CI 2.02–4.49,p-value 6.68 × 10−8 and rs8029377, MAF 0.03, OR 2.49, 95 % CI 1.76–3.53, p-value 2.45 × 10− 7). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. Conclusions: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood. |
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Costa, Gustavo N. O.Dudbridge, FrankFiaccone, Rosemeire LeovigildoSilva, Thiago M. daStrina, AgostinoFigueiredo, Camila A.Rodrigues, Laura C.Barreto, Mauricio LimaCosta, Gustavo N. O.Dudbridge, FrankFiaccone, Rosemeire LeovigildoSilva, Thiago M. daStrina, AgostinoFigueiredo, Camila A.Rodrigues, Laura C.Barreto, Mauricio Lima2016-05-04T12:34:23Z2016-05-04T12:34:23Z20151471-2156http://repositorio.ufba.br/ri/handle/ri/19061v.16, p.1-11Background: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. Methods: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC)questionnaire. Following quality control, 1 877 526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an stimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. Results: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95 % CI 1.45–2.18, p-value 2.83 × 10−8)and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95 % CI 2.02–4.49,p-value 6.68 × 10−8 and rs8029377, MAF 0.03, OR 2.49, 95 % CI 1.76–3.53, p-value 2.45 × 10− 7). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. Conclusions: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2016-05-04T12:34:23Z No. of bitstreams: 1 Art Per Estrang Mauricio L. Barreto. 2015.pdf: 1967757 bytes, checksum: 8839bb063988fc4af52bf6b679a8fd1d (MD5)Made available in DSpace on 2016-05-04T12:34:23Z (GMT). No. of bitstreams: 1 Art Per Estrang Mauricio L. Barreto. 2015.pdf: 1967757 bytes, checksum: 8839bb063988fc4af52bf6b679a8fd1d (MD5) Previous issue date: 2015-12LondonBioMed CentralBrasilhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669662/pdf/12863_2015_Article_296.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAsthma symptomsGenome-wide associationLatin AmericaChildrenA genome-wide association study of asthma symptoms in Latin American childrenBMC Genetinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALArt Per Estrang Mauricio L. Barreto. 2015.pdfArt Per Estrang Mauricio L. 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dc.title.pt_BR.fl_str_mv |
A genome-wide association study of asthma symptoms in Latin American children |
dc.title.alternative.pt_BR.fl_str_mv |
BMC Genet |
title |
A genome-wide association study of asthma symptoms in Latin American children |
spellingShingle |
A genome-wide association study of asthma symptoms in Latin American children Costa, Gustavo N. O. Asthma symptoms Genome-wide association Latin America Children |
title_short |
A genome-wide association study of asthma symptoms in Latin American children |
title_full |
A genome-wide association study of asthma symptoms in Latin American children |
title_fullStr |
A genome-wide association study of asthma symptoms in Latin American children |
title_full_unstemmed |
A genome-wide association study of asthma symptoms in Latin American children |
title_sort |
A genome-wide association study of asthma symptoms in Latin American children |
author |
Costa, Gustavo N. O. |
author_facet |
Costa, Gustavo N. O. Dudbridge, Frank Fiaccone, Rosemeire Leovigildo Silva, Thiago M. da Strina, Agostino Figueiredo, Camila A. Rodrigues, Laura C. Barreto, Mauricio Lima |
author_role |
author |
author2 |
Dudbridge, Frank Fiaccone, Rosemeire Leovigildo Silva, Thiago M. da Strina, Agostino Figueiredo, Camila A. Rodrigues, Laura C. Barreto, Mauricio Lima |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Gustavo N. O. Dudbridge, Frank Fiaccone, Rosemeire Leovigildo Silva, Thiago M. da Strina, Agostino Figueiredo, Camila A. Rodrigues, Laura C. Barreto, Mauricio Lima Costa, Gustavo N. O. Dudbridge, Frank Fiaccone, Rosemeire Leovigildo Silva, Thiago M. da Strina, Agostino Figueiredo, Camila A. Rodrigues, Laura C. Barreto, Mauricio Lima |
dc.subject.por.fl_str_mv |
Asthma symptoms Genome-wide association Latin America Children |
topic |
Asthma symptoms Genome-wide association Latin America Children |
description |
Background: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. Methods: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC)questionnaire. Following quality control, 1 877 526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an stimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. Results: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95 % CI 1.45–2.18, p-value 2.83 × 10−8)and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95 % CI 2.02–4.49,p-value 6.68 × 10−8 and rs8029377, MAF 0.03, OR 2.49, 95 % CI 1.76–3.53, p-value 2.45 × 10− 7). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. Conclusions: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-05-04T12:34:23Z |
dc.date.available.fl_str_mv |
2016-05-04T12:34:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/19061 |
dc.identifier.issn.none.fl_str_mv |
1471-2156 |
dc.identifier.number.pt_BR.fl_str_mv |
v.16, p.1-11 |
identifier_str_mv |
1471-2156 v.16, p.1-11 |
url |
http://repositorio.ufba.br/ri/handle/ri/19061 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
BioMed Central |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.pt_BR.fl_str_mv |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669662/pdf/12863_2015_Article_296.pdf |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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