Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release

Detalhes bibliográficos
Autor(a) principal: Reis, L. C.
Data de Publicação: 1994
Outros Autores: Ramalho, Maria José Pedreira, Favaretto, A. L. V., Gutkowska, Jolanta, Mccann, Samuel M., Rodrigues, José Antunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12966
Resumo: p. 12022-12026
id UFBA-2_debdeaa1108c24580d4060915506f6dd
oai_identifier_str oai:repositorio.ufba.br:ri/12966
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Reis, L. C.Ramalho, Maria José PedreiraFavaretto, A. L. V.Gutkowska, JolantaMccann, Samuel M.Rodrigues, José AntunesReis, L. C.Ramalho, Maria José PedreiraFavaretto, A. L. V.Gutkowska, JolantaMccann, Samuel M.Rodrigues, José Antunes2013-09-17T17:39:33Z2013-09-17T17:39:33Z1994http://www.repositorio.ufba.br/ri/handle/ri/12966v. 91p. 12022-12026Results obtained in our laboratories have provided evidence for the participation of the hypothalamic atrial natriuretic peptide (ANP) neuronal system in the regulation of water and electrolyte homeostasis. The anterior ventral third ventricular (AV3V) region, a site of the perikarya of the ANP neurons, receives important afferent input from ascending serotoninergic axons. We hypothesized that the ascending serotoninergic tract might be involved in control of the liberation of ANP. Therefore, electrolytic lesions were produced in the mesencephalic dorsal raph6 nucleus (DRN), the site of perikarya of serotonin (5-HT) neurons whose axons project to the AV3V region. Rats with sham lesions constituted the control group. In a second group of animals, the serotoninergic system was depleted of 5-HT by lateral ventricular administration of p-chlorophenylalanine (PCPA), an amino acid that causes depletion of 5-HT from the serotoninergic neurons. Control animals were inJected with an equal amount of isotonic saline. The DRN lesions induced an increase of water intake and urine output beinning on the first day that lasted for 1 week after lesions were produced. There was a concomitant sodium retention that lasted for the same period of time. When water-loaded, DRN-lesioned and PCPA-injected animals showed diminished excretion of sodium, accompanied by a decrease in basal plasma ANP concentrations, and blockade of the increase in plasma ANP, which followed blood volume expansion by intraatrial injection of hypertonic saline. The results are interpreted to mean that ascending stimulatory serotoninergic input into the ANP neuronal system in the AV3V region produces a tonic stimulation of ANP release, which augments sodium excretion and inhibits water intake. Therefore, in the absence of this serotoninergic input following destruction of the serotoninergic neurons by DRN lesions or intraventricular injection of PCPA, an antinatriuretic effect is obtained that is associated with increased drinking, either because of sodium retention per se or removal of ANP-induced inhibition of release of the dipsogenic peptide, angiotensin II. The serotoninergic afferents also play an essential, stimulatory role in volume expansion-induced release of ANP and the ensuing natriuresis.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-16T18:17:17Z No. of bitstreams: 1 2222222222222.pdf: 3263352 bytes, checksum: e716622cd9244fa3c002ebd12a9ed1e3 (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-09-17T17:39:33Z (GMT) No. of bitstreams: 1 2222222222222.pdf: 3263352 bytes, checksum: e716622cd9244fa3c002ebd12a9ed1e3 (MD5)Made available in DSpace on 2013-09-17T17:39:33Z (GMT). No. of bitstreams: 1 2222222222222.pdf: 3263352 bytes, checksum: e716622cd9244fa3c002ebd12a9ed1e3 (MD5) Previous issue date: 1994Salvadorhttp://www.pnas.org/content/91/25/12022.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASodium ExcretionWater IntakeVolume ExpansionDorsal Raphi Nucleus LesionsSerotonin DepletionParticipation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide releaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL2222222222222.pdf2222222222222.pdfapplication/pdf3263352https://repositorio.ufba.br/bitstream/ri/12966/1/2222222222222.pdfe716622cd9244fa3c002ebd12a9ed1e3MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12966/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT2222222222222.pdf.txt2222222222222.pdf.txtExtracted texttext/plain5https://repositorio.ufba.br/bitstream/ri/12966/3/2222222222222.pdf.txtcc9067c2ee470dc248b14b194209a34eMD53ri/129662022-07-05 14:03:02.765oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:02Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
title Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
spellingShingle Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
Reis, L. C.
Sodium Excretion
Water Intake
Volume Expansion
Dorsal Raphi Nucleus Lesions
Serotonin Depletion
title_short Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
title_full Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
title_fullStr Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
title_full_unstemmed Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
title_sort Participation of the ascending serotonergic system in the stimulation of atrial natriuretic peptide release
author Reis, L. C.
author_facet Reis, L. C.
Ramalho, Maria José Pedreira
Favaretto, A. L. V.
Gutkowska, Jolanta
Mccann, Samuel M.
Rodrigues, José Antunes
author_role author
author2 Ramalho, Maria José Pedreira
Favaretto, A. L. V.
Gutkowska, Jolanta
Mccann, Samuel M.
Rodrigues, José Antunes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, L. C.
Ramalho, Maria José Pedreira
Favaretto, A. L. V.
Gutkowska, Jolanta
Mccann, Samuel M.
Rodrigues, José Antunes
Reis, L. C.
Ramalho, Maria José Pedreira
Favaretto, A. L. V.
Gutkowska, Jolanta
Mccann, Samuel M.
Rodrigues, José Antunes
dc.subject.por.fl_str_mv Sodium Excretion
Water Intake
Volume Expansion
Dorsal Raphi Nucleus Lesions
Serotonin Depletion
topic Sodium Excretion
Water Intake
Volume Expansion
Dorsal Raphi Nucleus Lesions
Serotonin Depletion
description p. 12022-12026
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2013-09-17T17:39:33Z
dc.date.available.fl_str_mv 2013-09-17T17:39:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12966
dc.identifier.number.pt_BR.fl_str_mv v. 91
url http://www.repositorio.ufba.br/ri/handle/ri/12966
identifier_str_mv v. 91
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://www.pnas.org/content/91/25/12022.full.pdf+html
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/12966/1/2222222222222.pdf
https://repositorio.ufba.br/bitstream/ri/12966/2/license.txt
https://repositorio.ufba.br/bitstream/ri/12966/3/2222222222222.pdf.txt
bitstream.checksum.fl_str_mv e716622cd9244fa3c002ebd12a9ed1e3
1b89a9a0548218172d7c829f87a0eab9
cc9067c2ee470dc248b14b194209a34e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459459023863808

Registros relacionados