Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5500 |
Resumo: | texto completo: acesso restrito. p. 149–155. |
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Andrade, Everaldo Nery deGonçalves, Gleisy Kelly NevesOliveira, Thiago Henrique Caldeira deSantos, Caroline Silva dosSouza, Clarissa Leal Silva eFirmes, Luciana BarbosaMagalhães, Amélia Cristina Mendes deSoares, Telma de JesusReis, Adelina Martha dosBelo, Najara de OliveiraAndrade, Everaldo Nery deGonçalves, Gleisy Kelly NevesOliveira, Thiago Henrique Caldeira deSantos, Caroline Silva dosSouza, Clarissa Leal Silva eFirmes, Luciana BarbosaMagalhães, Amélia Cristina Mendes deSoares, Telma de JesusReis, Adelina Martha dosBelo, Najara de Oliveira2012-03-03T15:11:31Z20111873-1686http://www.repositorio.ufba.br/ri/handle/ri/5500v. 167.texto completo: acesso restrito. p. 149–155.The present study was designed to develop an animal model of hypertension and cardiac hypertrophy associated with obesity in female rats. Furthermore, we studied the involvement of the natriuretic peptide system in the mechanisms of these conditions. Obesity was induced in Wistar rats by a high fat diet and ovariectomy. The rats were divided into four groups: ovariectomized or sham-operated with high-fat diet and ovariectomized or sham-operated with control diet. After 24 weeks of diet, rats were killed, and their tissues were removed. Cardiac atrial natriuretic peptide (ANP), clearance receptor (NPr-C) gene expression was determined by PCR. ANP concentrations were measured in plasma. Ovariectomized fat-fed rats (OF) showed increased body weight, visceral fat depot and blood pressure and decreased sodium excretion compared to other groups. Also, these rats showed higher heart-to-body weight and cell diameters of ventricular cardiomyocytes and lower cardiac ANP mRNA and plasma ANP than the control group. The adipocyte and renal NPr-C mRNA of OF rats were higher than the control group. These data showed that combined ovariectomy and high fat diet elicited obesity, hypertension and cardiac hypertrophy. These results suggest that the impairment of the natriuretic peptide system may be one of the mechanisms involved not only in development of hypertension but also in cardiac hypertrophy associated with obesity in ovariectomized rats.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-03-03T15:11:31Z No. of bitstreams: 1 Natriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdf: 328925 bytes, checksum: 56d2f1cdfe046f72660fb1557a39b118 (MD5)Made available in DSpace on 2012-03-03T15:11:31Z (GMT). No. of bitstreams: 1 Natriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdf: 328925 bytes, checksum: 56d2f1cdfe046f72660fb1557a39b118 (MD5) Previous issue date: 2011doi:10.1016/j.regpep.2010.12.009reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEstrogenObesityANPHigh blood pressureNatriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female ratsRegulatory Peptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALNatriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdfNatriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdfapplication/pdf328925https://repositorio.ufba.br/bitstream/ri/5500/1/Natriuretic%20peptide%20system_%20A%20link%20between%20fat%20mass%20and%20cardiac%20hypertrophy%20and%20hypertension%20in%20fat-fed%20female%20rats.pdf56d2f1cdfe046f72660fb1557a39b118MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5500/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTNatriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdf.txtNatriuretic peptide system_ A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats.pdf.txtExtracted texttext/plain38994https://repositorio.ufba.br/bitstream/ri/5500/3/Natriuretic%20peptide%20system_%20A%20link%20between%20fat%20mass%20and%20cardiac%20hypertrophy%20and%20hypertension%20in%20fat-fed%20female%20rats.pdf.txtc6cf143cb81defa62db939f7027d1f39MD53ri/55002022-07-05 14:03:13.22oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| dc.title.alternative.pt_BR.fl_str_mv |
Regulatory Peptides |
| title |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| spellingShingle |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats Andrade, Everaldo Nery de Estrogen Obesity ANP High blood pressure |
| title_short |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| title_full |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| title_fullStr |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| title_full_unstemmed |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| title_sort |
Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats |
| author |
Andrade, Everaldo Nery de |
| author_facet |
Andrade, Everaldo Nery de Gonçalves, Gleisy Kelly Neves Oliveira, Thiago Henrique Caldeira de Santos, Caroline Silva dos Souza, Clarissa Leal Silva e Firmes, Luciana Barbosa Magalhães, Amélia Cristina Mendes de Soares, Telma de Jesus Reis, Adelina Martha dos Belo, Najara de Oliveira |
| author_role |
author |
| author2 |
Gonçalves, Gleisy Kelly Neves Oliveira, Thiago Henrique Caldeira de Santos, Caroline Silva dos Souza, Clarissa Leal Silva e Firmes, Luciana Barbosa Magalhães, Amélia Cristina Mendes de Soares, Telma de Jesus Reis, Adelina Martha dos Belo, Najara de Oliveira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Everaldo Nery de Gonçalves, Gleisy Kelly Neves Oliveira, Thiago Henrique Caldeira de Santos, Caroline Silva dos Souza, Clarissa Leal Silva e Firmes, Luciana Barbosa Magalhães, Amélia Cristina Mendes de Soares, Telma de Jesus Reis, Adelina Martha dos Belo, Najara de Oliveira Andrade, Everaldo Nery de Gonçalves, Gleisy Kelly Neves Oliveira, Thiago Henrique Caldeira de Santos, Caroline Silva dos Souza, Clarissa Leal Silva e Firmes, Luciana Barbosa Magalhães, Amélia Cristina Mendes de Soares, Telma de Jesus Reis, Adelina Martha dos Belo, Najara de Oliveira |
| dc.subject.por.fl_str_mv |
Estrogen Obesity ANP High blood pressure |
| topic |
Estrogen Obesity ANP High blood pressure |
| description |
texto completo: acesso restrito. p. 149–155. |
| publishDate |
2011 |
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2011 |
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2012-03-03T15:11:31Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.repositorio.ufba.br/ri/handle/ri/5500 |
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1873-1686 |
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v. 167. |
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1873-1686 v. 167. |
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http://www.repositorio.ufba.br/ri/handle/ri/5500 |
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eng |
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openAccess |
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doi:10.1016/j.regpep.2010.12.009 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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