Effect of Bothrops leucurus venom in chick biventer cervicis preparations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14458 |
Resumo: | Texto completo: acesso restrito. p. 595–603 |
| id |
UFBA-2_e4dbd90999aff3ba0014807de55272d9 |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/14458 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Silva, Rejane Maria Lira daPrianti Junior, Antonio C. G.Ribeiro, WellingtonMartins, Rodrigo A. B. LopesFranceschi, Julia PradoSimioni, Léa RodriguesHöfling, Maria Alice da CruzLeite, Gildo B.Hyslop, StephenCogo, José C.Silva, Rejane Maria Lira daPrianti Junior, Antonio C. G.Ribeiro, WellingtonMartins, Rodrigo A. B. LopesFranceschi, Julia PradoSimioni, Léa RodriguesHöfling, Maria Alice da CruzLeite, Gildo B.Hyslop, StephenCogo, José C.2014-01-23T18:15:16Z20030041-0101http://repositorio.ufba.br/ri/handle/ri/14458v. 41, n. 5Texto completo: acesso restrito. p. 595–603Bothrops leucurus is a poorly studied pitviper found in northeastern Brazil. We examined the action of B. leucurus venom (5–100 μg/ml) on contractile responses in chick biventer cervicis preparations. Muscle damage was assessed by quantifying the release of creatine kinase (CK) and by histological analysis. B. leucurus venom dose-dependently inhibited the contractile responses of indirectly stimulated preparations, the maximum inhibition with 100 μg of venom/ml being 74.0±6.6% (mean±SEM) after 120 min. The venom also reduced contractures to exogenous acetylcholine (55 and 110 μM) and K+ (13.4 mM) (85–100% reduction with 100 μg of venom/ml) and increased the release of CK (348±139 U/ml in controls vs 1260±263 U/ml with 20 μg of venom/ml after 120 min, p<0.05). The accompanying morphological changes included multivacuolated, swollen, amorphous fibers and agglutinated myofibrils. These results indicate that B. leucurus venom can adversely affect neuromuscular transmission and produce muscle damage in avian preparations.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-06T14:40:00Z No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-23T18:15:15Z (GMT) No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5)Made available in DSpace on 2014-01-23T18:15:16Z (GMT). No. of bitstreams: 1 Rejâne M. Lira-Da-Silva.pdf: 528438 bytes, checksum: 36c864bcd2ff89e9c9d5eb31e476554c (MD5) Previous issue date: 2003http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0041-0101(03)00002-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABothrops leucurusMyotoxinNeuromuscular junctionNeurotransmissionPhospholipase A2VenomEffect of Bothrops leucurus venom in chick biventer cervicis preparationsToxiconinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALRejâne M. Lira-Da-Silva.pdfRejâne M. Lira-Da-Silva.pdfapplication/pdf528438https://repositorio.ufba.br/bitstream/ri/14458/1/Rej%c3%a2ne%20M.%20Lira-Da-Silva.pdf36c864bcd2ff89e9c9d5eb31e476554cMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14458/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTRejâne M. Lira-Da-Silva.pdf.txtRejâne M. Lira-Da-Silva.pdf.txtExtracted texttext/plain28051https://repositorio.ufba.br/bitstream/ri/14458/3/Rej%c3%a2ne%20M.%20Lira-Da-Silva.pdf.txtd529564ac49abc38d7b4ccf8c5785c21MD53ri/144582022-07-05 14:03:12.71oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:12Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| dc.title.alternative.pt_BR.fl_str_mv |
Toxicon |
| title |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| spellingShingle |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations Silva, Rejane Maria Lira da Bothrops leucurus Myotoxin Neuromuscular junction Neurotransmission Phospholipase A2 Venom |
| title_short |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| title_full |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| title_fullStr |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| title_full_unstemmed |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| title_sort |
Effect of Bothrops leucurus venom in chick biventer cervicis preparations |
| author |
Silva, Rejane Maria Lira da |
| author_facet |
Silva, Rejane Maria Lira da Prianti Junior, Antonio C. G. Ribeiro, Wellington Martins, Rodrigo A. B. Lopes Franceschi, Julia Prado Simioni, Léa Rodrigues Höfling, Maria Alice da Cruz Leite, Gildo B. Hyslop, Stephen Cogo, José C. |
| author_role |
author |
| author2 |
Prianti Junior, Antonio C. G. Ribeiro, Wellington Martins, Rodrigo A. B. Lopes Franceschi, Julia Prado Simioni, Léa Rodrigues Höfling, Maria Alice da Cruz Leite, Gildo B. Hyslop, Stephen Cogo, José C. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Rejane Maria Lira da Prianti Junior, Antonio C. G. Ribeiro, Wellington Martins, Rodrigo A. B. Lopes Franceschi, Julia Prado Simioni, Léa Rodrigues Höfling, Maria Alice da Cruz Leite, Gildo B. Hyslop, Stephen Cogo, José C. Silva, Rejane Maria Lira da Prianti Junior, Antonio C. G. Ribeiro, Wellington Martins, Rodrigo A. B. Lopes Franceschi, Julia Prado Simioni, Léa Rodrigues Höfling, Maria Alice da Cruz Leite, Gildo B. Hyslop, Stephen Cogo, José C. |
| dc.subject.por.fl_str_mv |
Bothrops leucurus Myotoxin Neuromuscular junction Neurotransmission Phospholipase A2 Venom |
| topic |
Bothrops leucurus Myotoxin Neuromuscular junction Neurotransmission Phospholipase A2 Venom |
| description |
Texto completo: acesso restrito. p. 595–603 |
| publishDate |
2003 |
| dc.date.issued.fl_str_mv |
2003 |
| dc.date.accessioned.fl_str_mv |
2014-01-23T18:15:16Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/14458 |
| dc.identifier.issn.none.fl_str_mv |
0041-0101 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 41, n. 5 |
| identifier_str_mv |
0041-0101 v. 41, n. 5 |
| url |
http://repositorio.ufba.br/ri/handle/ri/14458 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.pt_BR.fl_str_mv |
http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0041-0101(03)00002-3 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/14458/1/Rej%c3%a2ne%20M.%20Lira-Da-Silva.pdf https://repositorio.ufba.br/bitstream/ri/14458/2/license.txt https://repositorio.ufba.br/bitstream/ri/14458/3/Rej%c3%a2ne%20M.%20Lira-Da-Silva.pdf.txt |
| bitstream.checksum.fl_str_mv |
36c864bcd2ff89e9c9d5eb31e476554c ff6eaa8b858ea317fded99f125f5fcd0 d529564ac49abc38d7b4ccf8c5785c21 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1808459468403376128 |