Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/35113 |
Resumo: | Purpose The aim of this study was to evaluate the capability of biomarkers to predict the risk of oral mucositis in head and neck cancer patients, as well as to assess the correlation be- tween these biomarkers and the severity of mucositis. Methods The search was performed at LILACS, PubMed, Science Direct, Scopus, and Web of Science. A search of the gray literature was performed on Google Scholar, OpenGrey, and ProQuest. The methodological quality of the included studies was assessed using the Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system. Results After a two-step selection process, 26 studies met the eligibility criteria. In total, 27 biomarkers were evaluated, and the most frequent were the epidermal growth factor (EGF), C- reactive protein (CRP), genetic polymorphisms, tumor necro- sis factor alpha (TNF- α ), and erythrocyte sedimentation rate (ESR). The meta-analysis showed an expression of polymorphisms in XRCC1 (32.66%), XRCC3 (31.00%), and RAD51 (39.16%) genes, as well as an expression of pro- tein biomarkers (39.57%), in patients with an increased risk of developing oral mucositis. Conclusions Dosing biomarkers before starting radiation therapy may be a promising method to predict the risk of developing mucositis and allow radiosensitive patients to have a customized treatment. Although there is currently limited evidence to confirm the putative implementation of serum and salivary biomarkers to assess the correlation between them and the severity of mucositis, this current review pro- vides new research directions. |
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Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysisBiomarcadoresBiomarkersStomatitisEstomatiteNeoplasias de Cabeça e PescoçoHead and Neck NeoplasmsPurpose The aim of this study was to evaluate the capability of biomarkers to predict the risk of oral mucositis in head and neck cancer patients, as well as to assess the correlation be- tween these biomarkers and the severity of mucositis. Methods The search was performed at LILACS, PubMed, Science Direct, Scopus, and Web of Science. A search of the gray literature was performed on Google Scholar, OpenGrey, and ProQuest. The methodological quality of the included studies was assessed using the Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system. Results After a two-step selection process, 26 studies met the eligibility criteria. In total, 27 biomarkers were evaluated, and the most frequent were the epidermal growth factor (EGF), C- reactive protein (CRP), genetic polymorphisms, tumor necro- sis factor alpha (TNF- α ), and erythrocyte sedimentation rate (ESR). The meta-analysis showed an expression of polymorphisms in XRCC1 (32.66%), XRCC3 (31.00%), and RAD51 (39.16%) genes, as well as an expression of pro- tein biomarkers (39.57%), in patients with an increased risk of developing oral mucositis. Conclusions Dosing biomarkers before starting radiation therapy may be a promising method to predict the risk of developing mucositis and allow radiosensitive patients to have a customized treatment. Although there is currently limited evidence to confirm the putative implementation of serum and salivary biomarkers to assess the correlation between them and the severity of mucositis, this current review pro- vides new research directions.Supportive Care in Cancer2018-08-27T12:33:36Z2018-08-27T12:33:36Z2017-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNORMANDO, A. G. C. et al. Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis. Supportive Care in Cancer, Berlin, v. 25, n. 9, p.2969–2988, sept. 2018.0941-43551433-7339 (Online)http://www.repositorio.ufc.br/handle/riufc/35113Normando, Ana Gabriela CostaRocha, Camila LopesToledo, Isabela Porto deFigueiredo, Paulo Tadeu de SouzaReis, Paula Elaine Diniz dosCanto, Graziela De LucaGuerra, Eliete Neves Silvaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-30T17:26:18Zoai:repositorio.ufc.br:riufc/35113Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2019-01-30T17:26:18Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
title |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
spellingShingle |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis Normando, Ana Gabriela Costa Biomarcadores Biomarkers Stomatitis Estomatite Neoplasias de Cabeça e Pescoço Head and Neck Neoplasms |
title_short |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
title_full |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
title_fullStr |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
title_full_unstemmed |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
title_sort |
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis |
author |
Normando, Ana Gabriela Costa |
author_facet |
Normando, Ana Gabriela Costa Rocha, Camila Lopes Toledo, Isabela Porto de Figueiredo, Paulo Tadeu de Souza Reis, Paula Elaine Diniz dos Canto, Graziela De Luca Guerra, Eliete Neves Silva |
author_role |
author |
author2 |
Rocha, Camila Lopes Toledo, Isabela Porto de Figueiredo, Paulo Tadeu de Souza Reis, Paula Elaine Diniz dos Canto, Graziela De Luca Guerra, Eliete Neves Silva |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Normando, Ana Gabriela Costa Rocha, Camila Lopes Toledo, Isabela Porto de Figueiredo, Paulo Tadeu de Souza Reis, Paula Elaine Diniz dos Canto, Graziela De Luca Guerra, Eliete Neves Silva |
dc.subject.por.fl_str_mv |
Biomarcadores Biomarkers Stomatitis Estomatite Neoplasias de Cabeça e Pescoço Head and Neck Neoplasms |
topic |
Biomarcadores Biomarkers Stomatitis Estomatite Neoplasias de Cabeça e Pescoço Head and Neck Neoplasms |
description |
Purpose The aim of this study was to evaluate the capability of biomarkers to predict the risk of oral mucositis in head and neck cancer patients, as well as to assess the correlation be- tween these biomarkers and the severity of mucositis. Methods The search was performed at LILACS, PubMed, Science Direct, Scopus, and Web of Science. A search of the gray literature was performed on Google Scholar, OpenGrey, and ProQuest. The methodological quality of the included studies was assessed using the Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system. Results After a two-step selection process, 26 studies met the eligibility criteria. In total, 27 biomarkers were evaluated, and the most frequent were the epidermal growth factor (EGF), C- reactive protein (CRP), genetic polymorphisms, tumor necro- sis factor alpha (TNF- α ), and erythrocyte sedimentation rate (ESR). The meta-analysis showed an expression of polymorphisms in XRCC1 (32.66%), XRCC3 (31.00%), and RAD51 (39.16%) genes, as well as an expression of pro- tein biomarkers (39.57%), in patients with an increased risk of developing oral mucositis. Conclusions Dosing biomarkers before starting radiation therapy may be a promising method to predict the risk of developing mucositis and allow radiosensitive patients to have a customized treatment. Although there is currently limited evidence to confirm the putative implementation of serum and salivary biomarkers to assess the correlation between them and the severity of mucositis, this current review pro- vides new research directions. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09 2018-08-27T12:33:36Z 2018-08-27T12:33:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NORMANDO, A. G. C. et al. Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis. Supportive Care in Cancer, Berlin, v. 25, n. 9, p.2969–2988, sept. 2018. 0941-4355 1433-7339 (Online) http://www.repositorio.ufc.br/handle/riufc/35113 |
identifier_str_mv |
NORMANDO, A. G. C. et al. Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis. Supportive Care in Cancer, Berlin, v. 25, n. 9, p.2969–2988, sept. 2018. 0941-4355 1433-7339 (Online) |
url |
http://www.repositorio.ufc.br/handle/riufc/35113 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Supportive Care in Cancer |
publisher.none.fl_str_mv |
Supportive Care in Cancer |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1809935799804755968 |