Antinociceptive and toxicological effects of Dioclea grandiflora seed pod in mice.

• Autor(a) principal: SÁ, Rita de Cássia da Silveira e.
• Data de Publicação: 2010
• Outros Autores: OLIVEIRA, Leandra Eugênia Gomes de., NÓBREGA, Franklin Ferreira de Farias., BHATTACHARYYA, Jnanabrata., ALMEIDA, Reinaldo Nóbrega de.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
• Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37242
• topic: Seed pod of Dioclea grandiflora; Dioclea grandiflora; Mucunã; Medicinal plant; Vagem de semente de Dioclea grandiflora; Dioclea grandiflora; Mucunã; Planta medicinal; Farmácia.; Química.

The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid- induced writhing test and the formalin test. The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phases in the formalin test. The hot plate test did not show an increase in the antinociceptive latency whereas the motor performance was affected by the administration at 300 mg/kg at the beginning (30 minutes) of the observation period but not at later periods (60 and 120 minutes). These results suggest that EDgP has a central antinociceptive action and a possible anti-inflammatory activity in mice.