Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/3909 |
Resumo: | Swine leptospirosis is a worldwide anthropozoonosis caused by spirochetes of the species Leptospira interrogans, predominantly by serovars Pomona, Icterohaemorrhagiae, Taravossi, Canicola Grippotyphosa and Bratislava. Experimental infection were performed in 18 sows at 40 days of age with L. interrogans serogroup Icterohaemorrhagiae serovar Conpenhageni strain Fiocruz L1-130, and serogroup Pomona serovar Kennewicki strain Pomona From divided in groups: GI (control), GII (inoculated with serogroup Pomona) and GIII (inoculated with serogroup Icterohaemorrhagiae). Clinical course of the disease, results of serological tests and detection of bacteria by polymerase chain reaction (PCR) and bacterial isolation during the experiment, were compared between groups. Additionally, the main histological changes observed in brain, liver, lymph nodes, lung and kidney of 12 animals experimentally infected and seropositive for leptospirosis were described. In lesions suggestive of the disease the technique of silver impregnation of Warthin-Starry, was used as direct detection method. During the experimental period, all samples of the GI (control) were negative in the microscopic agglutination test, with the GII positivity exclusive to serogroup Pomona in six animals from 6 dpi, and in GIII, only to serogroup Icterohaemorrhagiae in five animals from 3 dpi. At necropsy the only change was pale kidney in 50% of GI, 83.33% of GII and 83.33% of GIII (p> 0.05). Only in seropositive pigs was found lesions suggestive of leptospirosis as focal microgliosis in the brain (8.33%), lymphoid hyperplasia in lymph nodes of the mediastinum a nd mesentery (41.66%), mononuclear interstitial pneumonia (58.33 %), multifocal mononuclear hepatitis, further acute tubular nephrosis (100%) and interstitial nephritis (91.66%). There was a strong association between serological condition and lesions of mononuclear hepatitis (p = 0.0128), mononuclear interstitial nephritis (p = 0.0004), tubular nephrosis (p <0.0001) and mononuclear interstitial pneumonia (p = 0, 0377). |
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Brito, Luiz Augusto Batistahttp://lattes.cnpq.br/3212353728321020Matos, Moema Pacheco ChediakMoura, Veridiana Maria Brianezi Dignani deBrito, Luiz Augusto BatistaMiguel, Marina PachecoCoelho, Karyne OliveiraPascoal, Lívia MendonçaMenezes, Liliana Borges dehttp://lattes.cnpq.br/6346556753868080Santos, Adriana da Silva2015-01-16T19:07:03Z2014-05-30SANTOS, Adriana da Silva. Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona. 2014. 87 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/3909Swine leptospirosis is a worldwide anthropozoonosis caused by spirochetes of the species Leptospira interrogans, predominantly by serovars Pomona, Icterohaemorrhagiae, Taravossi, Canicola Grippotyphosa and Bratislava. Experimental infection were performed in 18 sows at 40 days of age with L. interrogans serogroup Icterohaemorrhagiae serovar Conpenhageni strain Fiocruz L1-130, and serogroup Pomona serovar Kennewicki strain Pomona From divided in groups: GI (control), GII (inoculated with serogroup Pomona) and GIII (inoculated with serogroup Icterohaemorrhagiae). Clinical course of the disease, results of serological tests and detection of bacteria by polymerase chain reaction (PCR) and bacterial isolation during the experiment, were compared between groups. Additionally, the main histological changes observed in brain, liver, lymph nodes, lung and kidney of 12 animals experimentally infected and seropositive for leptospirosis were described. In lesions suggestive of the disease the technique of silver impregnation of Warthin-Starry, was used as direct detection method. During the experimental period, all samples of the GI (control) were negative in the microscopic agglutination test, with the GII positivity exclusive to serogroup Pomona in six animals from 6 dpi, and in GIII, only to serogroup Icterohaemorrhagiae in five animals from 3 dpi. At necropsy the only change was pale kidney in 50% of GI, 83.33% of GII and 83.33% of GIII (p> 0.05). Only in seropositive pigs was found lesions suggestive of leptospirosis as focal microgliosis in the brain (8.33%), lymphoid hyperplasia in lymph nodes of the mediastinum a nd mesentery (41.66%), mononuclear interstitial pneumonia (58.33 %), multifocal mononuclear hepatitis, further acute tubular nephrosis (100%) and interstitial nephritis (91.66%). There was a strong association between serological condition and lesions of mononuclear hepatitis (p = 0.0128), mononuclear interstitial nephritis (p = 0.0004), tubular nephrosis (p <0.0001) and mononuclear interstitial pneumonia (p = 0, 0377).A leptospirose suína é uma antropozoonose difundida mundialmente e causada por espiroquetas da espécie Leptospira interrogans, principalmente pelos sorovares Pomona, Icterohaemorrhagiae, Taravossi, Canicola, Grippotyphosa e Bratislava. Neste trabalho descreve-se a infecção experimental por L. interrogans sorogrupo Icterohaemorrhagiae sorovar Conpenhageni estirpe Fiocruz L1 -130, e sorogrupo Pomona sorovar Kennewicki estirpe Pomona From, em 18 fêmeas suínas com 40 dias de idade divididas em três grupos: GI (controle), GII (inoculados com sorogrupo Pomona) e GIII (inoculados com sorogrupo Icterohaemorrhagiae). Compararam -se entre os grupos, o curso clínico da doença, os resultados dos exames sorológicos e de detecção da bactéria durante o período experimental pelas técnicas de reação em cadeia da polimerase (PCR) e isolamento bacteriano. Foram ainda descritas as principais alterações histológicas observadas em cérebro, fígado, linfonodos, pulmão e rins de 12 animais experimentalmente infectados e soropositivos para leptospirose. Em lesões sugestivas da doença utilizou-se a técnica de impregnação pela prata de Warthin-Starry, como método de detecção direta. Durante o período experimental foram negativas na soroaglutinação microscópica todas as amostras do GI (controle), havendo no GII positividade exclusiva ao sorogrupo Pomona nos seis animais a partir do 6º dia pós-infecção (dpi), e no GIII, apenas ao sorogrupo Icterohaemorrhagiae, em cinco animais a partir do 3º dpi. Na necropsia a única alteração observada foi rim pálido em 50% do G I, 83,33% do GII e em 83,33% GIII (p>0,05). Somente nos suínos soropositivos constataram-se lesões sugestivas de leptospirose, como microgliose mononuclear focal no cérebro (8,33%), hiperplasia linfoide em linfonodos do mediastino e mesentério (41,66%), pneumonia intersticial mononuclear multifocal (58,33%), hepatite mononuclear focal (41,66%), além de nefrose tubular aguda (100%) e nefrite intersticial (91,66%). Houve forte associação entre a condição sorológica e as lesões de hepatite mononuclear (p=0,0128), nefrite intersticial mononuclear (p=0,0004), nefrose tubular (p<0,0001) e pneumonia intersticial mononuclear (p=0,0377).Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-01-16T19:06:55Z No. of bitstreams: 2 Tese - Adriana da Silva Santos - 2014.pdf: 3299451 bytes, checksum: 52a612ede01e4713d7dd458d61176fe1 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-01-16T19:07:03Z (GMT) No. of bitstreams: 2 Tese - Adriana da Silva Santos - 2014.pdf: 3299451 bytes, checksum: 52a612ede01e4713d7dd458d61176fe1 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-01-16T19:07:03Z (GMT). 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dc.title.por.fl_str_mv |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
dc.title.alternative.eng.fl_str_mv |
Experimental infection of swines with Leptospira interrogans sorogroups icterohaemorrhagiae and pomona |
title |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
spellingShingle |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona Santos, Adriana da Silva Estirpe Fiocruz L1-130 Estirpe LPF Leptospirose suína Lesão renal Soroaglutinação microscópica Microscopic agglutination test Renal injury Strain Fiocruz L1-130 Strain LPF Swine leptospirosis MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
title_short |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
title_full |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
title_fullStr |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
title_full_unstemmed |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
title_sort |
Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona |
author |
Santos, Adriana da Silva |
author_facet |
Santos, Adriana da Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Brito, Luiz Augusto Batista |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3212353728321020 |
dc.contributor.advisor-co1.fl_str_mv |
Matos, Moema Pacheco Chediak |
dc.contributor.advisor-co2.fl_str_mv |
Moura, Veridiana Maria Brianezi Dignani de |
dc.contributor.referee1.fl_str_mv |
Brito, Luiz Augusto Batista |
dc.contributor.referee2.fl_str_mv |
Miguel, Marina Pacheco |
dc.contributor.referee3.fl_str_mv |
Coelho, Karyne Oliveira |
dc.contributor.referee4.fl_str_mv |
Pascoal, Lívia Mendonça |
dc.contributor.referee5.fl_str_mv |
Menezes, Liliana Borges de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6346556753868080 |
dc.contributor.author.fl_str_mv |
Santos, Adriana da Silva |
contributor_str_mv |
Brito, Luiz Augusto Batista Matos, Moema Pacheco Chediak Moura, Veridiana Maria Brianezi Dignani de Brito, Luiz Augusto Batista Miguel, Marina Pacheco Coelho, Karyne Oliveira Pascoal, Lívia Mendonça Menezes, Liliana Borges de |
dc.subject.por.fl_str_mv |
Estirpe Fiocruz L1-130 Estirpe LPF Leptospirose suína Lesão renal Soroaglutinação microscópica |
topic |
Estirpe Fiocruz L1-130 Estirpe LPF Leptospirose suína Lesão renal Soroaglutinação microscópica Microscopic agglutination test Renal injury Strain Fiocruz L1-130 Strain LPF Swine leptospirosis MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
dc.subject.eng.fl_str_mv |
Microscopic agglutination test Renal injury Strain Fiocruz L1-130 Strain LPF Swine leptospirosis |
dc.subject.cnpq.fl_str_mv |
MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL |
description |
Swine leptospirosis is a worldwide anthropozoonosis caused by spirochetes of the species Leptospira interrogans, predominantly by serovars Pomona, Icterohaemorrhagiae, Taravossi, Canicola Grippotyphosa and Bratislava. Experimental infection were performed in 18 sows at 40 days of age with L. interrogans serogroup Icterohaemorrhagiae serovar Conpenhageni strain Fiocruz L1-130, and serogroup Pomona serovar Kennewicki strain Pomona From divided in groups: GI (control), GII (inoculated with serogroup Pomona) and GIII (inoculated with serogroup Icterohaemorrhagiae). Clinical course of the disease, results of serological tests and detection of bacteria by polymerase chain reaction (PCR) and bacterial isolation during the experiment, were compared between groups. Additionally, the main histological changes observed in brain, liver, lymph nodes, lung and kidney of 12 animals experimentally infected and seropositive for leptospirosis were described. In lesions suggestive of the disease the technique of silver impregnation of Warthin-Starry, was used as direct detection method. During the experimental period, all samples of the GI (control) were negative in the microscopic agglutination test, with the GII positivity exclusive to serogroup Pomona in six animals from 6 dpi, and in GIII, only to serogroup Icterohaemorrhagiae in five animals from 3 dpi. At necropsy the only change was pale kidney in 50% of GI, 83.33% of GII and 83.33% of GIII (p> 0.05). Only in seropositive pigs was found lesions suggestive of leptospirosis as focal microgliosis in the brain (8.33%), lymphoid hyperplasia in lymph nodes of the mediastinum a nd mesentery (41.66%), mononuclear interstitial pneumonia (58.33 %), multifocal mononuclear hepatitis, further acute tubular nephrosis (100%) and interstitial nephritis (91.66%). There was a strong association between serological condition and lesions of mononuclear hepatitis (p = 0.0128), mononuclear interstitial nephritis (p = 0.0004), tubular nephrosis (p <0.0001) and mononuclear interstitial pneumonia (p = 0, 0377). |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-05-30 |
dc.date.accessioned.fl_str_mv |
2015-01-16T19:07:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Adriana da Silva. Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona. 2014. 87 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/3909 |
identifier_str_mv |
SANTOS, Adriana da Silva. Infecção experimental em suínos por Leptospira interrogans sorogrupos icterohaemorrhagiae e pomona. 2014. 87 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/3909 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
4581960685150189167 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-6217552114249094582 |
dc.relation.cnpq.fl_str_mv |
-8086848019297794803 |
dc.relation.sponsorship.fl_str_mv |
-2555911436985713659 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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