Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/6687 |
Resumo: | Alcoholism is a disease defined as a physical and / or mental condition, which characterized the need of the individual to ingest the substance constantly in order to experience its psychic effects or stop the withdrawal symptoms of the same. Heavy alcohol consumption brings many consequences for the health and quality of life by increasing the frequency of morbidity and mortality, causing several functional limitations. Worldwide, enormous resources are being invested in campaigns against alcohol abuse. WHO, for example, establishing a standard dose contains about 10 to 12 g of pure alcohol equivalent to a can of beer (350 mL) and draft (330 mL), a glass of wine (100ml), or distillate dose (30 mL). Some individuals metabolise alcohol better than others. The main ethanol elimination pathway occurs through oxidation of acetaldehyde to the same and then acid and water. These reactions are catalyzed by the enzyme alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). In this context, the scientific endeavor of this study to characterize the presence of polymorphisms of ADH and ALDH genes in alcohol users region of the state of Goiás, it is necessary to establish a possible correlation with alcoholism. This study was conducted in Goiás Alcoholics Recovery Center (GO CEREA) and Psychosocial Care Center Alcohol and Drugs (CAPS AD) both in Goiania. For the experiments, a sample of blood from each patient for DNA extraction was collected. Assays were performed by RT-PCR TaqMan SNP Genotyping Assays system. Statistical analyzes were made through GENEPOP 4.5 and Haploview software. Significant differences were found for SNPs studied in the analysis “Case vs. Control” and “Female vs. Male”. Furthermore, binding was observed moderate linkage disequilibrium between the ADH1B*2 and ADH1C*2 SNPs and the presence of haplotype by segregation dependent thereof. These results therefore suggest that these genetic variants may be associated with protection or addiction to alcoholism in the population studied in the city of Goiania, GO, Brazil. |
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Lacerda, Elisângela de Paula Silveirahttp://lattes.cnpq.br/9390789693192751Silva, Hugo Delleon dahttp://lattes.cnpq.br/5284079632565916Lacerda, Elisângela de Paula Silveirahttp://lattes.cnpq.br/9390789693192751Bérgamo , Nádia AparecidaRibolla, Paulo Eduardo MartinsReis , Ângela Adamski da Silvahttp://lattes.cnpq.br/1016749262144067Teixeira, Thallita Monteiro2017-01-04T16:37:24Z2016-03-28Monteiro, Thallita. Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil. 2016.70 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/6687Alcoholism is a disease defined as a physical and / or mental condition, which characterized the need of the individual to ingest the substance constantly in order to experience its psychic effects or stop the withdrawal symptoms of the same. Heavy alcohol consumption brings many consequences for the health and quality of life by increasing the frequency of morbidity and mortality, causing several functional limitations. Worldwide, enormous resources are being invested in campaigns against alcohol abuse. WHO, for example, establishing a standard dose contains about 10 to 12 g of pure alcohol equivalent to a can of beer (350 mL) and draft (330 mL), a glass of wine (100ml), or distillate dose (30 mL). Some individuals metabolise alcohol better than others. The main ethanol elimination pathway occurs through oxidation of acetaldehyde to the same and then acid and water. These reactions are catalyzed by the enzyme alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). In this context, the scientific endeavor of this study to characterize the presence of polymorphisms of ADH and ALDH genes in alcohol users region of the state of Goiás, it is necessary to establish a possible correlation with alcoholism. This study was conducted in Goiás Alcoholics Recovery Center (GO CEREA) and Psychosocial Care Center Alcohol and Drugs (CAPS AD) both in Goiania. For the experiments, a sample of blood from each patient for DNA extraction was collected. Assays were performed by RT-PCR TaqMan SNP Genotyping Assays system. Statistical analyzes were made through GENEPOP 4.5 and Haploview software. Significant differences were found for SNPs studied in the analysis “Case vs. Control” and “Female vs. Male”. Furthermore, binding was observed moderate linkage disequilibrium between the ADH1B*2 and ADH1C*2 SNPs and the presence of haplotype by segregation dependent thereof. These results therefore suggest that these genetic variants may be associated with protection or addiction to alcoholism in the population studied in the city of Goiania, GO, Brazil.O alcoolismo é uma doença definida como um estado físico e/ou psíquico onde se caracteriza a necessidade do indivíduo de ingerir a substância constantemente, no intuito de sentir seus efeitos psíquicos ou fazer cessar os sintomas da abstinência da mesma. O consumo abusivo de álcool traz inúmeras consequências para a saúde e qualidade de vida, aumentando a frequência de morbimortalidade, causando diversas limitações funcionais.Em todo o mundo, enormes recursos estão sendo investidos em campanhas contra o abuso do álcool.A OMS, por exemplo, estabelece que uma dose padrão contenha aproximadamente de 10 a 12 g de álcool puro, o equivalente a uma lata de cerveja (350 mL), ou chope (330 mL), uma taça de vinho (100 mL), ou uma dose de destilado (30 mL). Alguns indivíduos metabolizam o álcool melhor que outros. A principal via de eliminação do etanol ocorre por meio de oxidação do mesmo à acetaldeído e posteriormente em ácido e água. Estas reações são catalisadas pelas enzimas Álcool desidrogenase (ADH) e Aldeído desidrogenase (ALDH). Neste contexto, o empenho científico deste estudo para caracterizar a presença de polimorfismos nos genes ADH e ALDH nos usuários de álcool da região do Estado de Goiás, faz-se necessário para se estabelecer uma possível correlação com o alcoolismo. Este estudo foi realizado no Centro de Recuperação de Alcoólatras de Goiás – regional Goiânia (CEREA GO) e no Centro de Atenção Psicossocial Álcool e Drogas (CAPS AD). Para a realização dos experimentos, foi coletado uma amostra de sangue de cada paciente para extração de DNA. Os ensaios foram realizados através da PCR em Tempo Real pelo sistema TaqMAn® SNP Genotyping Assays. As análises estatísticas foram feitas através dossoftware GENEPOP 4.5 e Haploview.Foram encontradas diferenças significativas para os SNPs estudados nas análises Caso versus Controle e Feminino versus Masculino. Além disso, foi observada ligação moderada de Linkage disequilibrium entre os SNPs ADH1B*2 e ADH1C*2 e a presença de haplótipos através da segregação dependente destes. Estes resultados sugerem, portanto, que estas variantes genéticas possam estar associadas à proteção ou dependência ao alcoolismo na população estudada na cidade de Goiânia, GO, Brasil.Submitted by Jaqueline Silva (jtas29@gmail.com) on 2017-01-04T16:37:13Z No. of bitstreams: 2 Dissertação - Thallita Monteiro Teixeira - 2016.pdf: 2002902 bytes, checksum: 6b37cff3f40bb0248879b27757987f0d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2017-01-04T16:37:24Z (GMT) No. of bitstreams: 2 Dissertação - Thallita Monteiro Teixeira - 2016.pdf: 2002902 bytes, checksum: 6b37cff3f40bb0248879b27757987f0d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-01-04T16:37:24Z (GMT). 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dc.title.por.fl_str_mv |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
dc.title.alternative.eng.fl_str_mv |
Polymorphism study of alcohol dehydrogenase and aldehyde dehydrogenase (adh and aldh) genes and the alcohol dependence in a population of Goiania, GO, Brazil |
title |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
spellingShingle |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil Teixeira, Thallita Monteiro ADH Alcoolismo ALDH Polimorfismo ADH Alcoholism ALDH Polymorphism CIENCIAS DA SAUDE::FARMACIA |
title_short |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
title_full |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
title_fullStr |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
title_full_unstemmed |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
title_sort |
Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil |
author |
Teixeira, Thallita Monteiro |
author_facet |
Teixeira, Thallita Monteiro |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lacerda, Elisângela de Paula Silveira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9390789693192751 |
dc.contributor.advisor-co1.fl_str_mv |
Silva, Hugo Delleon da |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/5284079632565916 |
dc.contributor.referee1.fl_str_mv |
Lacerda, Elisângela de Paula Silveira |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9390789693192751 |
dc.contributor.referee2.fl_str_mv |
Bérgamo , Nádia Aparecida |
dc.contributor.referee3.fl_str_mv |
Ribolla, Paulo Eduardo Martins |
dc.contributor.referee4.fl_str_mv |
Reis , Ângela Adamski da Silva |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1016749262144067 |
dc.contributor.author.fl_str_mv |
Teixeira, Thallita Monteiro |
contributor_str_mv |
Lacerda, Elisângela de Paula Silveira Silva, Hugo Delleon da Lacerda, Elisângela de Paula Silveira Bérgamo , Nádia Aparecida Ribolla, Paulo Eduardo Martins Reis , Ângela Adamski da Silva |
dc.subject.por.fl_str_mv |
ADH Alcoolismo ALDH Polimorfismo |
topic |
ADH Alcoolismo ALDH Polimorfismo ADH Alcoholism ALDH Polymorphism CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
ADH Alcoholism ALDH Polymorphism |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Alcoholism is a disease defined as a physical and / or mental condition, which characterized the need of the individual to ingest the substance constantly in order to experience its psychic effects or stop the withdrawal symptoms of the same. Heavy alcohol consumption brings many consequences for the health and quality of life by increasing the frequency of morbidity and mortality, causing several functional limitations. Worldwide, enormous resources are being invested in campaigns against alcohol abuse. WHO, for example, establishing a standard dose contains about 10 to 12 g of pure alcohol equivalent to a can of beer (350 mL) and draft (330 mL), a glass of wine (100ml), or distillate dose (30 mL). Some individuals metabolise alcohol better than others. The main ethanol elimination pathway occurs through oxidation of acetaldehyde to the same and then acid and water. These reactions are catalyzed by the enzyme alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). In this context, the scientific endeavor of this study to characterize the presence of polymorphisms of ADH and ALDH genes in alcohol users region of the state of Goiás, it is necessary to establish a possible correlation with alcoholism. This study was conducted in Goiás Alcoholics Recovery Center (GO CEREA) and Psychosocial Care Center Alcohol and Drugs (CAPS AD) both in Goiania. For the experiments, a sample of blood from each patient for DNA extraction was collected. Assays were performed by RT-PCR TaqMan SNP Genotyping Assays system. Statistical analyzes were made through GENEPOP 4.5 and Haploview software. Significant differences were found for SNPs studied in the analysis “Case vs. Control” and “Female vs. Male”. Furthermore, binding was observed moderate linkage disequilibrium between the ADH1B*2 and ADH1C*2 SNPs and the presence of haplotype by segregation dependent thereof. These results therefore suggest that these genetic variants may be associated with protection or addiction to alcoholism in the population studied in the city of Goiania, GO, Brazil. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-03-28 |
dc.date.accessioned.fl_str_mv |
2017-01-04T16:37:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Monteiro, Thallita. Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil. 2016.70 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/6687 |
identifier_str_mv |
Monteiro, Thallita. Estudo sobre o polimorfismo dos genes álcool desidrogenase e aldeído desidrogenase (gene adh e aldh) e a dependência ao álcool em uma população da cidade de Goiânia-GO, Brasil. 2016.70 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/6687 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
824936988196152412 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
6010281161524209375 |
dc.relation.cnpq.fl_str_mv |
6997636413449754996 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
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