PLASMATIC VARIATION OF VASOACTIVE AMINES IN HORSES UNDER EFFECT OF CARBOHYDRATE OVERLOAD AND NON-STEROIDAL ANTIINFLAMMATORIES

• Autor(a) principal: Costa, Renata Sampaio
• Data de Publicação: 2012
• Outros Autores: Botteon, Paulo de Tarso, Ferraz, Vany, Paes Leme, Fabíola de O., Faleiros, Rafael Resende, Silveira Alves, Geraldo Eleno
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Ciência animal brasileira (Online)
• Texto Completo: https://revistas.ufg.br/vet/article/view/6970
• topic: Animal Sanity; Eqüino; aminas vasoativas; antiinflamatórios não esteroidais.

Twenty horses were submitted to carbohydrate overload (CO) and plasmatic concentrations of the bioactive amine serotonin (5-HT), putrescin (PUT) and cadaverin (CAD) were determined by gas chromatography. After 36h of carbohydrate overloading, horses were randomly distributed into four groups (n=5) and were submitted to four intravenous treatments every 12 hours. The treatments were as follows: 10ml of saline (GC), ketoprofen 2.2mg/kg (GK), phenylbutazone 4.4mg/kg (GF), and flunixin meglumine 1.1mg/kg (GFM). Blood samples were collected at regular intervals (0-72h) after the CO. After 6h, there were peaks in the concentrations of 5-HT, which rapidly returned to values above the basal standard. No variations of PUT concentrations were observed; however CAD concentrations increased at 6h, remaining elevated (with some variation) until the end of the observation period. In conclusion, CO induced early (6h) increases in plasmatic concentrations of 5-HT and CAD. Plasmatic concentrations of the amines were not changed by any of the treatments used.KEYWORDS: equine; NSAIDs; vasoactives amines.