SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Ciência animal brasileira (Online) |
Texto Completo: | https://revistas.ufg.br/vet/article/view/10148 |
Resumo: | The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase. |
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SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURSATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORASAnimal sanityECMOcãeslactato desidrogenase.The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase.A oxigenação extracorpórea por membrana (ECMO) é uma técnica de suporte cardiopulmonar prolongado, que objetiva auxiliar os pulmões e/ou o coração quando estes não respondem aos tratamentos convencionais. Este estudo avaliou a atividade da lactato desidrogenase (LDH) sérica de cinco cães sem raça definida (SRD) submetidos à ECMO por um período de três horas. Sob pressão expiratória positiva final (PEEP) de 10mmHg, ventilação controlada e FiO2 de 21%, a ECMO foi realizada por canulação femoral (artéria e veia), em um desvio artério-venoso (AV). A atividade da LDH foi mensurada a cada trinta minutos, por três horas e os resultados analisados estatisticamente com os testes de ANOVA e Tukey, com atividade da LDH, caracterizando uma lesão muscular ao longo do procedimento, em virtude de uma resposta fisiológica semelhante àquela causada por um choque hipovolêmico. Conclui-se que a ECMO é uma técnica viável de suporte, mas necessita de adaptações para uso clínico em cães.PALAVRAS-CHAVE: cães; ECMO; lactato desidrogenase.Universidade Federal de Goiás2011-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResearchAvaliado por paresPesquisa científicaapplication/pdftext/htmlhttps://revistas.ufg.br/vet/article/view/1014810.5216/cab.v12i3.10148Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 12 No. 3 (2011); 554-559Ciência Animal Brasileira / Brazilian Animal Science; v. 12 n. 3 (2011); 554-5591809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/vet/article/view/10148/9716https://revistas.ufg.br/vet/article/view/10148/9717Ferreira, Felipp SilveiraSilveira, Lara LagesCosta, Alessandra CastelloVale, Daniela FantiniCarvalho, Claudio BaptistaMachado, Josias AlvesOliveira, André L. de Abreuinfo:eu-repo/semantics/openAccess2012-07-01T14:38:07Zoai:ojs.revistas.ufg.br:article/10148Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:55:44.491899Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true |
dc.title.none.fl_str_mv |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS ATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORAS |
title |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
spellingShingle |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS Ferreira, Felipp Silveira Animal sanity ECMO cães lactato desidrogenase. |
title_short |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
title_full |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
title_fullStr |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
title_full_unstemmed |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
title_sort |
SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS |
author |
Ferreira, Felipp Silveira |
author_facet |
Ferreira, Felipp Silveira Silveira, Lara Lages Costa, Alessandra Castello Vale, Daniela Fantini Carvalho, Claudio Baptista Machado, Josias Alves Oliveira, André L. de Abreu |
author_role |
author |
author2 |
Silveira, Lara Lages Costa, Alessandra Castello Vale, Daniela Fantini Carvalho, Claudio Baptista Machado, Josias Alves Oliveira, André L. de Abreu |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Felipp Silveira Silveira, Lara Lages Costa, Alessandra Castello Vale, Daniela Fantini Carvalho, Claudio Baptista Machado, Josias Alves Oliveira, André L. de Abreu |
dc.subject.por.fl_str_mv |
Animal sanity ECMO cães lactato desidrogenase. |
topic |
Animal sanity ECMO cães lactato desidrogenase. |
description |
The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Research Avaliado por pares Pesquisa científica |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/10148 10.5216/cab.v12i3.10148 |
url |
https://revistas.ufg.br/vet/article/view/10148 |
identifier_str_mv |
10.5216/cab.v12i3.10148 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/10148/9716 https://revistas.ufg.br/vet/article/view/10148/9717 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 12 No. 3 (2011); 554-559 Ciência Animal Brasileira / Brazilian Animal Science; v. 12 n. 3 (2011); 554-559 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
_version_ |
1799874787031384064 |