Ausência de associação dos polimorfismos genéticos do gene UCP3 e a força de preensão palmar em adultos da região metropolitana de Goiânia (Goiás, Brasil)

• Autor(a) principal: Cruz, Raphael Silva da
• Data de Publicação: 2019
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/9694
• topic: Sarcopenia; Envelhecimento; Espécies reativas de oxigênio; Força muscular; Sarcopenia; Aging; Reactive oxygen species; Muscle strength; CIENCIAS DA SAUDE::MEDICINA

Longevity is one of the great achievements of mankind. Aging is a continuous and physiological process, characterized and recognized by the diminished functional capacity of various biological systems. Sarcopenia and decreased muscle strength are characteristic of this process. Evaluation of palmar grip strength (FPP) is an important measure to estimate the impairment of a person's overall muscular strength and has been highlighted in studies of genetic susceptibility underlying aging. In this context, the objective of the present study was to verify the relationship between the unique nucleotide polymorphisms (SNPs) rs1800849, rs15763, rs3781907, rs647126, rs1685354 and rs11235972 of the UCP3 gene and the FPP in a group of adult people from the city of Goiânia. The present study was of the cross-sectional type, composed of 159 participants from the population of Goiás, who underwent an evaluation of FPP and the collection of biological samples for genotyping through the qPCR of the polymorphic sites of the UCP3 gene. Of the participants, 69.2% were women. The mean age was 50.4 (± 20.2) years, and that of FPP was 29.5 (± 14.6) kgf. It was observed that 42.8% of the study participants showed a reduction in FPP in relation to age and a negative and statistically significant correlation between FPP and age (r = -0.54; p≤0.0001). The FPP peak in the study participants was below 40 years for both women and men. A significant decrease in FPP was observed at age 50 also for both sexes. SNPs rs647126 and rs1685354 had the highest binding imbalance (D '= 1) with 32% r 2. The three most frequent haplotypes in the study population were h2 (GAGGAA), h13 (GGAAAA) and h16 (AAAGGG), whose frequencies were 26.2%, 22.2% and 12.9%, respectively. To evaluate muscular strength as an important component to understand the sarcopenia and the aging of the human organism. In the present study, the variation of polymorphisms rs1800849, rs15763, rs1685354, rs3781907, rs11235972 and rs647126 of the UCP3 gene was not associated with the reduction of FPP in adults living in Goiânia, Goiás, Brazil.