Omeprazole use and risk of chronic kidney disease evolution
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1371/journal.pone.0229344 http://hdl.handle.net/1843/50095 https://orcid.org/0000-0002-4812-7030 https://orcid.org/0000-0003-1313-7228 https://orcid.org/0000-0001-6379-0415 https://orcid.org/0000-0003-0183-1175 https://orcid.org/0000-0002-8126-3026 |
Resumo: | Rationale, aims and objectives: In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD. This study aims to analyze the association between the continuous use of omeprazole and the progression of CKD in adult and elderly individuals. Method: A retrospective cohort study was conducted with patients followed up at a nephrology clinic in Brazil, in 2016 and 2017. Information about clinical and sociodemographic data, health behaviors, and medication use were collected from all patients diagnosed with CKD through consultation of medical charts and the Brazilian health information system (SIS). The participants were allocated into two groups: users and non-users of omeprazole, and the progression of CKD was then evaluated for each group. In the bivariate analysis, the Mann-Whitney U test to compare the quantitative variables between groups, and the Pearson/Fisher two-tailed chi-square test to compare the categorical variables were applied. Multivariate analysis was performed using Cox regression. Results: A total of 199 CKD patients were attended in the polyclinic, and of these, 42.7% were omeprazole users. There was a higher percentage of CKD progression in users (70.6%) compared to non-users (10.5%). The hazard ratio was 7.34 (CI: 3.94–13.71), indicating a higher risk of progression to worse stages of CKD in omeprazole users than in non-users. As for the other variables, no statistically significant difference was found between groups (p > 0.05). Conclusion: An association between omeprazole use and progression of CKD stage was identified, showing a higher risk of disease evolution among omeprazole users. |
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2023-02-15T20:16:58Z2023-02-15T20:16:58Z2020-03-04153e0229344https://doi.org/10.1371/journal.pone.02293441932-6203http://hdl.handle.net/1843/50095https://orcid.org/0000-0002-4812-7030https://orcid.org/0000-0003-1313-7228https://orcid.org/0000-0001-6379-0415https://orcid.org/0000-0003-0183-1175https://orcid.org/0000-0002-8126-3026Rationale, aims and objectives: In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD. This study aims to analyze the association between the continuous use of omeprazole and the progression of CKD in adult and elderly individuals. Method: A retrospective cohort study was conducted with patients followed up at a nephrology clinic in Brazil, in 2016 and 2017. Information about clinical and sociodemographic data, health behaviors, and medication use were collected from all patients diagnosed with CKD through consultation of medical charts and the Brazilian health information system (SIS). The participants were allocated into two groups: users and non-users of omeprazole, and the progression of CKD was then evaluated for each group. In the bivariate analysis, the Mann-Whitney U test to compare the quantitative variables between groups, and the Pearson/Fisher two-tailed chi-square test to compare the categorical variables were applied. Multivariate analysis was performed using Cox regression. Results: A total of 199 CKD patients were attended in the polyclinic, and of these, 42.7% were omeprazole users. There was a higher percentage of CKD progression in users (70.6%) compared to non-users (10.5%). The hazard ratio was 7.34 (CI: 3.94–13.71), indicating a higher risk of progression to worse stages of CKD in omeprazole users than in non-users. As for the other variables, no statistically significant difference was found between groups (p > 0.05). Conclusion: An association between omeprazole use and progression of CKD stage was identified, showing a higher risk of disease evolution among omeprazole users.Justificativa, metas e objetivos: Nos últimos anos, o uso de inibidores da bomba de prótons (IBP), especialmente o omeprazol, tem sido associado ao desenvolvimento de doença renal crônica (DRC). Essas drogas são amplamente utilizadas em todo o mundo. Embora alguns estudos tenham encontrado associação entre o uso de IBP e o aparecimento de insuficiência renal aguda e DRC. Este estudo tem como objetivo analisar a associação entre o uso contínuo de omeprazol e a progressão da DRC em adultos e idosos. Método: Foi realizado um estudo de coorte retrospectivo com pacientes acompanhados em uma clínica de nefrologia no Brasil, em 2016 e 2017. Informações sobre dados clínicos e sociodemográficos, comportamentos de saúde e uso de medicamentos foram coletadas de todos os pacientes diagnosticados com DRC por meio de consulta aos prontuários médicos e o Sistema Brasileiro de Informações em Saúde (SIS). Os participantes foram alocados em dois grupos: usuários e não usuários de omeprazol, e a progressão da DRC foi então avaliada para cada grupo. Na análise bivariada, foram aplicados o teste U de Mann-Whitney para comparar as variáveis quantitativas entre os grupos e o teste qui-quadrado bicaudal de Pearson/Fisher para comparar as variáveis categóricas. A análise multivariada foi realizada por regressão de Cox. Resultados: Foram atendidos na policlínica 199 pacientes com DRC, sendo que destes, 42,7% eram usuários de omeprazol. Houve maior percentual de progressão da DRC em usuários (70,6%) em relação aos não usuários (10,5%). A taxa de risco foi de 7,34 (IC: 3,94–13,71), indicando um risco maior de progressão para estágios piores da DRC em usuários de omeprazol do que em não usuários. Quanto às demais variáveis, não houve diferença estatisticamente significativa entre os grupos (p > 0,05). Conclusão: Foi identificada associação entre o uso de omeprazol e a progressão do estágio da DRC, mostrando maior risco de evolução da doença entre os usuários de omeprazol.engUniversidade Federal de Minas GeraisUFMGBrasilDAT - DEPARTAMENTO DE ATENCAO SAUDE TRABALHADORInibidores da bomba de prótonsOmeprazolDoenças renais crônicasOmeprazolDoença renal crônicaInibidores da bomba de prótonsOmeprazole use and risk of chronic kidney disease evolutionUso de omeprazol e risco de evolução para doença renal crônicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229344João Victor Marques GuedesJéssica Azevedo de AquinoTássia Lima Bernardino CastroFlávio Augusto de MoraisAndré Oliveira BaldoniVinícius Silva BeloAlba Otoniapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/50095/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALOmeprazole use and risk of chronic kidney.pdfOmeprazole use and risk of chronic kidney.pdfapplication/pdf2367533https://repositorio.ufmg.br/bitstream/1843/50095/2/Omeprazole%20use%20and%20risk%20of%20chronic%20kidney.pdfec5846d9a4021ec47797104e810093f3MD521843/500952023-02-15 17:16:58.595oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-02-15T20:16:58Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Omeprazole use and risk of chronic kidney disease evolution |
dc.title.alternative.pt_BR.fl_str_mv |
Uso de omeprazol e risco de evolução para doença renal crônica |
title |
Omeprazole use and risk of chronic kidney disease evolution |
spellingShingle |
Omeprazole use and risk of chronic kidney disease evolution João Victor Marques Guedes Omeprazol Doença renal crônica Inibidores da bomba de prótons Inibidores da bomba de prótons Omeprazol Doenças renais crônicas |
title_short |
Omeprazole use and risk of chronic kidney disease evolution |
title_full |
Omeprazole use and risk of chronic kidney disease evolution |
title_fullStr |
Omeprazole use and risk of chronic kidney disease evolution |
title_full_unstemmed |
Omeprazole use and risk of chronic kidney disease evolution |
title_sort |
Omeprazole use and risk of chronic kidney disease evolution |
author |
João Victor Marques Guedes |
author_facet |
João Victor Marques Guedes Jéssica Azevedo de Aquino Tássia Lima Bernardino Castro Flávio Augusto de Morais André Oliveira Baldoni Vinícius Silva Belo Alba Otoni |
author_role |
author |
author2 |
Jéssica Azevedo de Aquino Tássia Lima Bernardino Castro Flávio Augusto de Morais André Oliveira Baldoni Vinícius Silva Belo Alba Otoni |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
João Victor Marques Guedes Jéssica Azevedo de Aquino Tássia Lima Bernardino Castro Flávio Augusto de Morais André Oliveira Baldoni Vinícius Silva Belo Alba Otoni |
dc.subject.por.fl_str_mv |
Omeprazol Doença renal crônica Inibidores da bomba de prótons |
topic |
Omeprazol Doença renal crônica Inibidores da bomba de prótons Inibidores da bomba de prótons Omeprazol Doenças renais crônicas |
dc.subject.other.pt_BR.fl_str_mv |
Inibidores da bomba de prótons Omeprazol Doenças renais crônicas |
description |
Rationale, aims and objectives: In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD. This study aims to analyze the association between the continuous use of omeprazole and the progression of CKD in adult and elderly individuals. Method: A retrospective cohort study was conducted with patients followed up at a nephrology clinic in Brazil, in 2016 and 2017. Information about clinical and sociodemographic data, health behaviors, and medication use were collected from all patients diagnosed with CKD through consultation of medical charts and the Brazilian health information system (SIS). The participants were allocated into two groups: users and non-users of omeprazole, and the progression of CKD was then evaluated for each group. In the bivariate analysis, the Mann-Whitney U test to compare the quantitative variables between groups, and the Pearson/Fisher two-tailed chi-square test to compare the categorical variables were applied. Multivariate analysis was performed using Cox regression. Results: A total of 199 CKD patients were attended in the polyclinic, and of these, 42.7% were omeprazole users. There was a higher percentage of CKD progression in users (70.6%) compared to non-users (10.5%). The hazard ratio was 7.34 (CI: 3.94–13.71), indicating a higher risk of progression to worse stages of CKD in omeprazole users than in non-users. As for the other variables, no statistically significant difference was found between groups (p > 0.05). Conclusion: An association between omeprazole use and progression of CKD stage was identified, showing a higher risk of disease evolution among omeprazole users. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-03-04 |
dc.date.accessioned.fl_str_mv |
2023-02-15T20:16:58Z |
dc.date.available.fl_str_mv |
2023-02-15T20:16:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/50095 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1371/journal.pone.0229344 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
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https://orcid.org/0000-0002-4812-7030 https://orcid.org/0000-0003-1313-7228 https://orcid.org/0000-0001-6379-0415 https://orcid.org/0000-0003-0183-1175 https://orcid.org/0000-0002-8126-3026 |
url |
https://doi.org/10.1371/journal.pone.0229344 http://hdl.handle.net/1843/50095 https://orcid.org/0000-0002-4812-7030 https://orcid.org/0000-0003-1313-7228 https://orcid.org/0000-0001-6379-0415 https://orcid.org/0000-0003-0183-1175 https://orcid.org/0000-0002-8126-3026 |
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1932-6203 |
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eng |
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eng |
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Universidade Federal de Minas Gerais |
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Brasil |
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DAT - DEPARTAMENTO DE ATENCAO SAUDE TRABALHADOR |
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Universidade Federal de Minas Gerais |
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