Salivary gland cancer in southern Brazil: a prognostic study of 107 cases

• Autor(a) principal: Virgilio Gonzales Zanella
• Data de Publicação: 2020
• Outros Autores: Pablo Agustin Vargas, Manoela Domingues Martins, Vivian Petersen Wagner, Tuany Rafaeli Schmidt, Stefanie Thieme, Cintia Correa, Felipe Paiva Fonseca, Pettala Rigon, Marinez Bizarro Barra, Ricardo Gallicchio Kroef
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.4317%2Fmedoral.24248; http://hdl.handle.net/1843/61821
• topic: título periódico Medicina oral patologia oral y cirugia bucal busca dia 24 do mes 11 ano 2023 fao clínica open acess assunto Head and Neck Neoplasms; Salivary gland cancer in southern brazil: a prognostic study of 107 cases título periódico Medicina oral patologia oral y cirugia bucal busca dia 24 do mes 11 ano 2023 fao clínica open acess assunto Head and Neck Neoplasms; Head and neck neoplasms; Epithelial cells; Rare diseases; Epidemiology; Prognosis; Recurrence; Carcinoma; Survival

Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features. Material and methods: Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information. Results: One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02). Conclusions: The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up.