Expression of EGFR family and p53 in a patient with Synchronous Primary Endometrial Adenocarcinoma and Clear Cell Renal Carcinoma: a case report

• Autor(a) principal: Priscila Fernanda da Silva Martins
• Data de Publicação: 2019
• Outros Autores: Izabella Cristina Alves Souza, Enio Ferreira, Emerson Soares Veloso, Tatiany Luiza Silveira, Adam Underwood, Fabiano Conde Araujo, Helen Lima Del-Puerto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.5935/2526-8732.20190011; http://hdl.handle.net/1843/56434; https://orcid.org/0000-0002-1835-0303; https://orcid.org/0000-0003-4696-7738; https://orcid.org/0000-0001-7090-6535; https://orcid.org/0000-0001-8232-4129; https://orcid.org/0000-0002-8384-0480; https://orcid.org/0000-0002-4142-7401
• topic: Endometrial carcinoma; Renal clear cell carcinoma; EGFR family; p53; Neoplasias do Endométrio; Carcinoma de Células Renais; Genes erbB-1; Genes p53

We present a case of a 69 year-old, non-obese, post-menopausal woman diagnosed with synchronous endometrial adenocarcinoma and renal cell carcinoma. Immunolocalization and expression of the EGFR, HER-2, HER-3, HER-4 and p53 proteins by immunohistochemistry (IHC) was performed to investigate synchronous expression of these proteins. The endometrial adenocarcinoma was a well-differentiated tumor, with discernable glandular structure with moderate mitotic index. IHC revealed weak HER-2, HER-3 and HER-4 staining of cell membranes in well-differentiated areas, and intense HER-2 and p53 staining in papillary areas. The renal cell carcinoma showed clear cell type, solid tumor, Fuhrman nuclear grade 2, presence of necrosis and hemorrhage. IHC revealed intense HER-2 and HER-4 staining of cell membranes, weak EGFR staining, and negative expression for HER3 and p53 protein. In summary, overexpression of HER-2 and HER-4 may correlate with histological grade of the tumor and patient prognosis.