Age-related metabolic pathways changes in dental follicles: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/froh.2021.677731 http://hdl.handle.net/1843/55553 https://orcid.org/0000-0002-4125-3755 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-06-29T17:52:13Z2023-06-29T17:52:13Z2021219https://doi.org/10.3389/froh.2021.6777312673-4842http://hdl.handle.net/1843/55553https://orcid.org/0000-0002-4125-3755CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorAging is not a matter of choice; it is our fate. The “time-dependent functional decline that affects most living organisms” is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth. The more we understand the physiology of dental follicles, the more we are able to contextualize biological events that can be associated with the occurrence of odontogenic lesions, whose incidence increases with age. Thus, our objective was to assess age-related changes in metabolic pathways of dental follicles associated with unerupted/impacted mandibular third molars from young and adult individuals. For this purpose, a convenience sample of formalin-fixed paraffin-embedded (FFPE) dental follicles from young (<16 y.o., n = 13) and adult (>26 y.o., n = 7) individuals was selected. Samples were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS)-based untargeted metabolomics. Multivariate and univariate analyses were conducted, and the prediction of altered pathways was performed by mummichog and Gene Set Enrichment Analysis (GSEA) approaches. Dental follicles from young and older individuals showed differences in pathways related to C21-steroid hormone biosynthesis, bile acid biosynthesis, galactose metabolism, androgen and estrogen biosynthesis, starch and sucrose metabolism, and lipoate metabolism. We conclude that metabolic pathways differences related to aging were observed between dental follicles from young and adult individuals. Our findings support that similar to other human tissues, dental follicles associated with unerupted tooth show alterations at a metabolic level with aging, which can pave the way for further studies on oral pathology, oral biology, and physiology.engUniversidade Federal de Minas GeraisUFMGBrasilENG - DEPARTAMENTO DE ENGENHARIA SANITÁRIA E AMBIENTALICB - DEPARTAMENTO DE MORFOLOGIAICB - DEPARTAMENTO DE PATOLOGIAICX - DEPARTAMENTO DE QUÍMICAFrontiers in Oral HealthCélulas - EnvelhecimentoDentes - DoençasBiologia do desenvolvimentoBoca - Doenças - DiagnósticoCromatografia líquidaEspectrometria de massaAgingDental follicleDental sacDevelopmental biologyOral pathologyUntargeted metabolomicsLC-MSAge-related metabolic pathways changes in dental follicles: a pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/froh.2021.677731/fullVictor Coutinho BastosLiséte Celina LangeAdriana Nori de MacedoGisele André Baptista CanutoCarolina Cavaliéri GomesRicardo Santiago GomezJéssica Gardone VitórioRoberta Rayra Martins-chavesFlávia Leite-LimaYuri Abner Rocha LebronVictor Rezende MoreiraFilipe Fideles Duarte-AndradeThaís Dos Santos Fontes PereiraLucilaine Valéria de Souza Santosapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/55553/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALAge-related metabolic pathways changes in dental follicles a pilot study (1).pdfAge-related metabolic pathways changes in dental follicles a pilot study (1).pdfapplication/pdf2061813https://repositorio.ufmg.br/bitstream/1843/55553/2/Age-related%20metabolic%20pathways%20changes%20in%20dental%20follicles%20a%20pilot%20study%20%281%29.pdf845c7a935a4b4214b87b87fa32c8b5b7MD521843/555532023-06-29 14:52:13.554oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-29T17:52:13Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Age-related metabolic pathways changes in dental follicles: a pilot study |
title |
Age-related metabolic pathways changes in dental follicles: a pilot study |
spellingShingle |
Age-related metabolic pathways changes in dental follicles: a pilot study Victor Coutinho Bastos Aging Dental follicle Dental sac Developmental biology Oral pathology Untargeted metabolomics LC-MS Células - Envelhecimento Dentes - Doenças Biologia do desenvolvimento Boca - Doenças - Diagnóstico Cromatografia líquida Espectrometria de massa |
title_short |
Age-related metabolic pathways changes in dental follicles: a pilot study |
title_full |
Age-related metabolic pathways changes in dental follicles: a pilot study |
title_fullStr |
Age-related metabolic pathways changes in dental follicles: a pilot study |
title_full_unstemmed |
Age-related metabolic pathways changes in dental follicles: a pilot study |
title_sort |
Age-related metabolic pathways changes in dental follicles: a pilot study |
author |
Victor Coutinho Bastos |
author_facet |
Victor Coutinho Bastos Liséte Celina Lange Adriana Nori de Macedo Gisele André Baptista Canuto Carolina Cavaliéri Gomes Ricardo Santiago Gomez Jéssica Gardone Vitório Roberta Rayra Martins-chaves Flávia Leite-Lima Yuri Abner Rocha Lebron Victor Rezende Moreira Filipe Fideles Duarte-Andrade Thaís Dos Santos Fontes Pereira Lucilaine Valéria de Souza Santos |
author_role |
author |
author2 |
Liséte Celina Lange Adriana Nori de Macedo Gisele André Baptista Canuto Carolina Cavaliéri Gomes Ricardo Santiago Gomez Jéssica Gardone Vitório Roberta Rayra Martins-chaves Flávia Leite-Lima Yuri Abner Rocha Lebron Victor Rezende Moreira Filipe Fideles Duarte-Andrade Thaís Dos Santos Fontes Pereira Lucilaine Valéria de Souza Santos |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Victor Coutinho Bastos Liséte Celina Lange Adriana Nori de Macedo Gisele André Baptista Canuto Carolina Cavaliéri Gomes Ricardo Santiago Gomez Jéssica Gardone Vitório Roberta Rayra Martins-chaves Flávia Leite-Lima Yuri Abner Rocha Lebron Victor Rezende Moreira Filipe Fideles Duarte-Andrade Thaís Dos Santos Fontes Pereira Lucilaine Valéria de Souza Santos |
dc.subject.por.fl_str_mv |
Aging Dental follicle Dental sac Developmental biology Oral pathology Untargeted metabolomics LC-MS |
topic |
Aging Dental follicle Dental sac Developmental biology Oral pathology Untargeted metabolomics LC-MS Células - Envelhecimento Dentes - Doenças Biologia do desenvolvimento Boca - Doenças - Diagnóstico Cromatografia líquida Espectrometria de massa |
dc.subject.other.pt_BR.fl_str_mv |
Células - Envelhecimento Dentes - Doenças Biologia do desenvolvimento Boca - Doenças - Diagnóstico Cromatografia líquida Espectrometria de massa |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-06-29T17:52:13Z |
dc.date.available.fl_str_mv |
2023-06-29T17:52:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/55553 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/froh.2021.677731 |
dc.identifier.issn.pt_BR.fl_str_mv |
2673-4842 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-4125-3755 |
url |
https://doi.org/10.3389/froh.2021.677731 http://hdl.handle.net/1843/55553 https://orcid.org/0000-0002-4125-3755 |
identifier_str_mv |
2673-4842 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Oral Health |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ENG - DEPARTAMENTO DE ENGENHARIA SANITÁRIA E AMBIENTAL ICB - DEPARTAMENTO DE MORFOLOGIA ICB - DEPARTAMENTO DE PATOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
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UFMG |
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Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
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