Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.20945/2359-3997000000039 http://hdl.handle.net/1843/50637 https://orcid.org/0000-0001-6132-4349 https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0001-9038-2185 https://orcid.org/0000-0003-0748-7141 https://orcid.org/0000-0003-2315-5980 https://orcid.org/0000-0003-0834-904X http://orcid.org/0000-0002-3804-8865 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0001-7675-7470 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-03-03T17:10:20Z2023-03-03T17:10:20Z2018-06623275284https://doi.org/10.20945/2359-39970000000392359-4292http://hdl.handle.net/1843/50637https://orcid.org/0000-0001-6132-4349https://orcid.org/0000-0003-0187-6402https://orcid.org/0000-0002-8684-7290https://orcid.org/0000-0001-9038-2185https://orcid.org/0000-0003-0748-7141https://orcid.org/0000-0003-2315-5980https://orcid.org/0000-0003-0834-904Xhttp://orcid.org/0000-0002-3804-8865https://orcid.org/0000-0003-3896-2208https://orcid.org/0000-0001-7675-7470CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloObjectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE ESPORTESInflamaçãoRegeneração ósseaObesidadeAdolescentesPerda de pesoInflammationBone turnover markersObesityAdolescentsWeight lossRelationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/aem/a/8ffB8dr5SfVNSFpmZPFWHWQ/abstract/?lang=enRaquel Munhoz da Silveira CamposDeborah Cristina Landi MasquioFlávia Campos CorgosinhoJoana Pereira de Carvalho FerreiraBárbara Dal Molin NettoAna Paula Grotti ClementeLian TockSergio TufikMarco Túlio de MelloAna Raimunda Dâmasoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/50637/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALRelationship between adiponectin and leptin on osteocalcin in obese adolescents.pdfRelationship between adiponectin and leptin on osteocalcin in obese adolescents.pdfapplication/pdf168536https://repositorio.ufmg.br/bitstream/1843/50637/2/Relationship%20between%20adiponectin%20and%20leptin%20on%20osteocalcin%20in%20obese%20adolescents.pdfe28f9eab890bb2eb1dc5be1d5095bc17MD521843/506372023-03-03 14:10:20.474oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-03-03T17:10:20Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| title |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| spellingShingle |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy Raquel Munhoz da Silveira Campos Inflammation Bone turnover markers Obesity Adolescents Weight loss Inflamação Regeneração óssea Obesidade Adolescentes Perda de peso |
| title_short |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| title_full |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| title_fullStr |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| title_full_unstemmed |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| title_sort |
Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy |
| author |
Raquel Munhoz da Silveira Campos |
| author_facet |
Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Flávia Campos Corgosinho Joana Pereira de Carvalho Ferreira Bárbara Dal Molin Netto Ana Paula Grotti Clemente Lian Tock Sergio Tufik Marco Túlio de Mello Ana Raimunda Dâmaso |
| author_role |
author |
| author2 |
Deborah Cristina Landi Masquio Flávia Campos Corgosinho Joana Pereira de Carvalho Ferreira Bárbara Dal Molin Netto Ana Paula Grotti Clemente Lian Tock Sergio Tufik Marco Túlio de Mello Ana Raimunda Dâmaso |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Flávia Campos Corgosinho Joana Pereira de Carvalho Ferreira Bárbara Dal Molin Netto Ana Paula Grotti Clemente Lian Tock Sergio Tufik Marco Túlio de Mello Ana Raimunda Dâmaso |
| dc.subject.por.fl_str_mv |
Inflammation Bone turnover markers Obesity Adolescents Weight loss |
| topic |
Inflammation Bone turnover markers Obesity Adolescents Weight loss Inflamação Regeneração óssea Obesidade Adolescentes Perda de peso |
| dc.subject.other.pt_BR.fl_str_mv |
Inflamação Regeneração óssea Obesidade Adolescentes Perda de peso |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-06 |
| dc.date.accessioned.fl_str_mv |
2023-03-03T17:10:20Z |
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2023-03-03T17:10:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/50637 |
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https://doi.org/10.20945/2359-3997000000039 |
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2359-4292 |
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https://orcid.org/0000-0001-6132-4349 https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0001-9038-2185 https://orcid.org/0000-0003-0748-7141 https://orcid.org/0000-0003-2315-5980 https://orcid.org/0000-0003-0834-904X http://orcid.org/0000-0002-3804-8865 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0001-7675-7470 |
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https://doi.org/10.20945/2359-3997000000039 http://hdl.handle.net/1843/50637 https://orcid.org/0000-0001-6132-4349 https://orcid.org/0000-0003-0187-6402 https://orcid.org/0000-0002-8684-7290 https://orcid.org/0000-0001-9038-2185 https://orcid.org/0000-0003-0748-7141 https://orcid.org/0000-0003-2315-5980 https://orcid.org/0000-0003-0834-904X http://orcid.org/0000-0002-3804-8865 https://orcid.org/0000-0003-3896-2208 https://orcid.org/0000-0001-7675-7470 |
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2359-4292 |
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eng |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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EEF - DEPARTAMENTO DE ESPORTES |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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