New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/0102-311X00184218 http://hdl.handle.net/1843/59161 http://orcid.org/0000-0002-6324-4702 http://orcid.org/0000-0002-3244-2271 http://orcid.org/0000-0001-7002-4428 http://orcid.org/0000-0003-2744-7139 http://orcid.org/0000-0002-4340-0659 |
Resumo: | This study sought to develop and evaluate a new patient-reported outcome measure to assess perceived barriers to antiretroviral therapy (ART) adherence. The Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) scale was developed based on individual interviews with patients. After pilot testing and assessing the evidence based on content analysis, the scale’s revisions resulted in a 40-item version. The PEDIA was applied to 415 HIV-infected adults receiving ART for a maximum of 180 days, recruited from three healthcare facilities of reference in the city of Belo Horizonte, Minas Gerais State, Brazil. The analyses included exploratory factor analysis, internal consistency, item response theory, temporal stability, and predictive test-criterion relationship. The scale’s final version contains 18 items distributed in three dimensions, as follows: cognitive and routine problems (4 items); medication and health concerns (6 items); and patient’s fears and feelings (8 items). The results of McDonald’s omega and temporal stability demonstrate that the PEDIA is internally consistent and yields stable scores over time. The assessment of the information’s functions suggested that the three dimensions were informative for assessing a broad range of latent traits. Evidence concerning the test-criterion relationship confirmed that the PEDIA was able to predict non-adherence three months later. Our findings suggest that the PEDIA is a psychometrically adequate tool for evaluating perceived barriers in adult patients initiating ART. It could be used in both research and clinical practice for the early detection of patients at risk of non-adherence and for the identification of potentially modifiable barriers. |
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2023-10-04T19:39:19Z2023-10-04T19:39:19Z2019355https://doi.org/10.1590/0102-311X001842181678-4464http://hdl.handle.net/1843/59161http://orcid.org/0000-0002-6324-4702http://orcid.org/0000-0002-3244-2271http://orcid.org/0000-0001-7002-4428http://orcid.org/0000-0003-2744-7139http://orcid.org/0000-0002-4340-0659This study sought to develop and evaluate a new patient-reported outcome measure to assess perceived barriers to antiretroviral therapy (ART) adherence. The Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) scale was developed based on individual interviews with patients. After pilot testing and assessing the evidence based on content analysis, the scale’s revisions resulted in a 40-item version. The PEDIA was applied to 415 HIV-infected adults receiving ART for a maximum of 180 days, recruited from three healthcare facilities of reference in the city of Belo Horizonte, Minas Gerais State, Brazil. The analyses included exploratory factor analysis, internal consistency, item response theory, temporal stability, and predictive test-criterion relationship. The scale’s final version contains 18 items distributed in three dimensions, as follows: cognitive and routine problems (4 items); medication and health concerns (6 items); and patient’s fears and feelings (8 items). The results of McDonald’s omega and temporal stability demonstrate that the PEDIA is internally consistent and yields stable scores over time. The assessment of the information’s functions suggested that the three dimensions were informative for assessing a broad range of latent traits. Evidence concerning the test-criterion relationship confirmed that the PEDIA was able to predict non-adherence three months later. Our findings suggest that the PEDIA is a psychometrically adequate tool for evaluating perceived barriers in adult patients initiating ART. It could be used in both research and clinical practice for the early detection of patients at risk of non-adherence and for the identification of potentially modifiable barriers.Este estudo teve por objetivo o desenvolvimento e avaliação de uma nova medida de desfecho relatada pelo paciente para avaliar barreiras percebidas à adesão à terapia antirretroviral (TARV). A escala Percepção de Dificuldades com o Tratamento Antirretroviral (PEDIA) foi desenvolvida com base em entrevistas com pacientes. Após teste piloto e avaliação de evidências com base no conteúdo do teste, revisões da escala resultaram em uma versão com 40 itens. A PEDIA foi aplicada em 415 adultos soropositivos para HIV que receberam TARV por um máximo de 180 dias, recrutados de três unidades de saúde de referência na cidade de Belo Horizonte, Minas Gerais, Brasil. As análises incluíram análise fatorial exploratória, consistência interna, teoria da resposta ao item, estabilidade temporal, e relação preditiva teste-critério. A versão final da escala contém 18 itens distribuídos em três dimensões, no caso: problemas cognitivos e de rotina (4 itens); preocupações com medicamentos e saúde (6 itens); e medos e sentimentos do paciente (8 itens). Resultados do ômega de McDonald e estabilidade temporal demonstram que a PEDIA é internamente consistente e produz escores estáveis ao longo do tempo. As funções de informação do teste sugerem que as três dimensões foram informativas na avaliação de uma ampla gama do traço latente. Evidências relacionadas à relação teste-critério confirmaram que a PEDIA foi capaz de prever não-adesão três meses depois. Nossos resultados sugerem que a PEDIA é uma ferramenta robusta do ponto de vista psicométrico para a avaliação das barreiras percebidas por pacientes adultos que iniciam TARV. Ela pode ser usada em contextos clínicos e de pesquisa para a detecção precoce de pacientes em risco de não-adesão e para a identificação de barreiras potencialmente modificáveis.FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisengUniversidade Federal de Minas GeraisUFMGBrasilFAF - DEPARTAMENTO DE PSICOLOGIAFAR - DEPARTAMENTO DE FARMÁCIA SOCIALMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALCadernos de Saúde PúblicaMedidas de resultados relatados pelo pacientePsicometriaInfecções por HIVAdesão à medicaçãoPatient reported outcome measuresPsychometricsHIV infectionsMedication adherenceNew patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scaleUma nova medida de desfecho relatada pelo paciente para avaliar barreiras percebidas à adesão à terapia antirretroviral: a escala PEDIAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/csp/a/RwFf79RxVSFJXP7yfdJvSFk/?lang=en#Celline Cardoso Almeida-BrasilElizabeth do NascimentoMicheline Rosa SilveiraPalmira de Fátima BonoloMaria Das Graças Braga Ceccatoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/59161/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALNew patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence_ the PEDIA scale.pdfNew patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence_ the PEDIA scale.pdfapplication/pdf297797https://repositorio.ufmg.br/bitstream/1843/59161/2/New%20patient-reported%20outcome%20measure%20to%20assess%20perceived%20barriers%20to%20antiretroviral%20therapy%20adherence_%20the%20PEDIA%20scale.pdff8557886e3ad61fb40dd75b6ea471b73MD521843/591612023-10-04 16:39:19.231oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-04T19:39:19Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
dc.title.alternative.pt_BR.fl_str_mv |
Uma nova medida de desfecho relatada pelo paciente para avaliar barreiras percebidas à adesão à terapia antirretroviral: a escala PEDIA |
title |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
spellingShingle |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale Celline Cardoso Almeida-Brasil Patient reported outcome measures Psychometrics HIV infections Medication adherence Medidas de resultados relatados pelo paciente Psicometria Infecções por HIV Adesão à medicação |
title_short |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
title_full |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
title_fullStr |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
title_full_unstemmed |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
title_sort |
New patient-reported outcome measure to assess perceived barriers to antiretroviral therapy adherence: the PEDIA scale |
author |
Celline Cardoso Almeida-Brasil |
author_facet |
Celline Cardoso Almeida-Brasil Elizabeth do Nascimento Micheline Rosa Silveira Palmira de Fátima Bonolo Maria Das Graças Braga Ceccato |
author_role |
author |
author2 |
Elizabeth do Nascimento Micheline Rosa Silveira Palmira de Fátima Bonolo Maria Das Graças Braga Ceccato |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Celline Cardoso Almeida-Brasil Elizabeth do Nascimento Micheline Rosa Silveira Palmira de Fátima Bonolo Maria Das Graças Braga Ceccato |
dc.subject.por.fl_str_mv |
Patient reported outcome measures Psychometrics HIV infections Medication adherence |
topic |
Patient reported outcome measures Psychometrics HIV infections Medication adherence Medidas de resultados relatados pelo paciente Psicometria Infecções por HIV Adesão à medicação |
dc.subject.other.pt_BR.fl_str_mv |
Medidas de resultados relatados pelo paciente Psicometria Infecções por HIV Adesão à medicação |
description |
This study sought to develop and evaluate a new patient-reported outcome measure to assess perceived barriers to antiretroviral therapy (ART) adherence. The Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) scale was developed based on individual interviews with patients. After pilot testing and assessing the evidence based on content analysis, the scale’s revisions resulted in a 40-item version. The PEDIA was applied to 415 HIV-infected adults receiving ART for a maximum of 180 days, recruited from three healthcare facilities of reference in the city of Belo Horizonte, Minas Gerais State, Brazil. The analyses included exploratory factor analysis, internal consistency, item response theory, temporal stability, and predictive test-criterion relationship. The scale’s final version contains 18 items distributed in three dimensions, as follows: cognitive and routine problems (4 items); medication and health concerns (6 items); and patient’s fears and feelings (8 items). The results of McDonald’s omega and temporal stability demonstrate that the PEDIA is internally consistent and yields stable scores over time. The assessment of the information’s functions suggested that the three dimensions were informative for assessing a broad range of latent traits. Evidence concerning the test-criterion relationship confirmed that the PEDIA was able to predict non-adherence three months later. Our findings suggest that the PEDIA is a psychometrically adequate tool for evaluating perceived barriers in adult patients initiating ART. It could be used in both research and clinical practice for the early detection of patients at risk of non-adherence and for the identification of potentially modifiable barriers. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-10-04T19:39:19Z |
dc.date.available.fl_str_mv |
2023-10-04T19:39:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/59161 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/0102-311X00184218 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-4464 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0002-6324-4702 http://orcid.org/0000-0002-3244-2271 http://orcid.org/0000-0001-7002-4428 http://orcid.org/0000-0003-2744-7139 http://orcid.org/0000-0002-4340-0659 |
url |
https://doi.org/10.1590/0102-311X00184218 http://hdl.handle.net/1843/59161 http://orcid.org/0000-0002-6324-4702 http://orcid.org/0000-0002-3244-2271 http://orcid.org/0000-0001-7002-4428 http://orcid.org/0000-0003-2744-7139 http://orcid.org/0000-0002-4340-0659 |
identifier_str_mv |
1678-4464 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Cadernos de Saúde Pública |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAF - DEPARTAMENTO DE PSICOLOGIA FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL |
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Universidade Federal de Minas Gerais |
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