Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata.
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/3856 http://dx.doi.org/10.1590/S0100-40422012000700017 |
Resumo: | The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α- di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina. |
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Rodrigues, Vanessa GregórioDuarte, Lucienir PainsSilva, Grácia Divina de FátimaSilva, Fernando CésarGóes, Jefferson Vieira deTakahashi, Jacqueline AparecidaPimenta, Lúcia Pinheiro SantosVieira Filho, Sidney Augusto2014-11-14T18:21:58Z2014-11-14T18:21:58Z2012RODRIGUES, V. G. et al. Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. Química Nova, v. 35, p. 1375-1380, 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700017>. Acesso em: 20 ago. 2014.1678-7064http://www.repositorio.ufop.br/handle/123456789/3856http://dx.doi.org/10.1590/S0100-40422012000700017The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α- di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.Maytenus imbricataCelastraceaePentacyclic triterpenesEvaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleA Sociedade Brasileira de Química dá permissão à UFOP para reproduzir no RI/UFOP, uma cópia em formato eletrônico dos artigos completos, sem nenhuma edição e/ou modificação, publicados na revista Química Nova, que tenham como autores seus alunos e/ou professores. Fonte: Email do editor de 17 set. 2013.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/3856/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALARTIGO_EvaluationAntimicrobialActivity.pdfARTIGO_EvaluationAntimicrobialActivity.pdfapplication/pdf1722626http://www.repositorio.ufop.br/bitstream/123456789/3856/1/ARTIGO_EvaluationAntimicrobialActivity.pdf52113dbbee6e1072c8c951e1c95b6f2fMD51123456789/38562019-05-09 13:55:22.606oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-05-09T17:55:22Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
title |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
spellingShingle |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. Rodrigues, Vanessa Gregório Maytenus imbricata Celastraceae Pentacyclic triterpenes |
title_short |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
title_full |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
title_fullStr |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
title_full_unstemmed |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
title_sort |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. |
author |
Rodrigues, Vanessa Gregório |
author_facet |
Rodrigues, Vanessa Gregório Duarte, Lucienir Pains Silva, Grácia Divina de Fátima Silva, Fernando César Góes, Jefferson Vieira de Takahashi, Jacqueline Aparecida Pimenta, Lúcia Pinheiro Santos Vieira Filho, Sidney Augusto |
author_role |
author |
author2 |
Duarte, Lucienir Pains Silva, Grácia Divina de Fátima Silva, Fernando César Góes, Jefferson Vieira de Takahashi, Jacqueline Aparecida Pimenta, Lúcia Pinheiro Santos Vieira Filho, Sidney Augusto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Vanessa Gregório Duarte, Lucienir Pains Silva, Grácia Divina de Fátima Silva, Fernando César Góes, Jefferson Vieira de Takahashi, Jacqueline Aparecida Pimenta, Lúcia Pinheiro Santos Vieira Filho, Sidney Augusto |
dc.subject.por.fl_str_mv |
Maytenus imbricata Celastraceae Pentacyclic triterpenes |
topic |
Maytenus imbricata Celastraceae Pentacyclic triterpenes |
description |
The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α- di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-11-14T18:21:58Z |
dc.date.available.fl_str_mv |
2014-11-14T18:21:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RODRIGUES, V. G. et al. Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. Química Nova, v. 35, p. 1375-1380, 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700017>. Acesso em: 20 ago. 2014. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/3856 |
dc.identifier.issn.none.fl_str_mv |
1678-7064 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0100-40422012000700017 |
identifier_str_mv |
RODRIGUES, V. G. et al. Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata. Química Nova, v. 35, p. 1375-1380, 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700017>. Acesso em: 20 ago. 2014. 1678-7064 |
url |
http://www.repositorio.ufop.br/handle/123456789/3856 http://dx.doi.org/10.1590/S0100-40422012000700017 |
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eng |
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