Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/6620 https://doi.org/10.1016/j.npep.2015.09.002 |
Resumo: | The central and peripheral renin–angiotensin systems are known for playing a key role in cardiovascular control. In the present study,we evaluated the hemodynamic effects produced by nanoinjections of angiotensin II (Ang II) or angiotensin-(1–7) [Ang-(1–7)] into the rostral ventrolateral medulla (RVLM) of adult male normotensive (Wistar—WT) and spontaneously hypertensive rats (SHR). Animals were anesthetized (urethane 1.2 g/kg) and instrumented for recording blood pressure (BP), heart rate (HR) and blood flow (BF) in the femoral, renal or mesenteric arteries. Afterwards, rats were positioned in a stereotaxic and prepared for nanoinjections (100 nl) of saline (NaCl 0.9%), Ang-(1–7) (40 ng) or Ang II (40 ng) into the RVLM. The vascular resistance (VR)was calculated by ΔMAP/ΔBF ratio. In WT, Ang-(1–7) or Ang II caused equipotent pressor effects that were not accompanied by changes in vascular resistance. However, MAP changes were greater in SHR. This strain also showed a concomitant increase in relative vascular resistance (ΔVR/VRbaseline) of renal (0.31 ± 0.07 and 0.3 ± 0.07 vs. 0.02 ± 0.01; Ang-(1–7), Ang II and Saline, respectively) and mesenteric beds (0.3 ± 0.06 and 0.33 ± 0.04 vs. 0.05 ± 0.02; Ang-(1–7), Ang II and saline, respectively). We conclude that Ang II and Ang-(1–7) at the RVLM control the vascular resistance of renal and mesenteric beds during hypertension. |
id |
UFOP_1eb03998686235f682f7168eaee2aac1 |
---|---|
oai_identifier_str |
oai:localhost:123456789/6620 |
network_acronym_str |
UFOP |
network_name_str |
Repositório Institucional da UFOP |
repository_id_str |
3233 |
spelling |
Ferreira, Patrícia MariaCustódio, Carlos Henrique XavierAlzamora, Andréia CarvalhoSantos, Robson Augusto Souza dosSantos, Maria José Campagnole dos2016-07-25T16:18:43Z2016-07-25T16:18:43Z2015FERREIRA, P. M. et al. Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. Neuropeptides, Edinburgh, v. 1, p. 00-00, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0143417915000918>. Acesso em: 16 jun. 2016.0143-4179http://www.repositorio.ufop.br/handle/123456789/6620https://doi.org/10.1016/j.npep.2015.09.002The central and peripheral renin–angiotensin systems are known for playing a key role in cardiovascular control. In the present study,we evaluated the hemodynamic effects produced by nanoinjections of angiotensin II (Ang II) or angiotensin-(1–7) [Ang-(1–7)] into the rostral ventrolateral medulla (RVLM) of adult male normotensive (Wistar—WT) and spontaneously hypertensive rats (SHR). Animals were anesthetized (urethane 1.2 g/kg) and instrumented for recording blood pressure (BP), heart rate (HR) and blood flow (BF) in the femoral, renal or mesenteric arteries. Afterwards, rats were positioned in a stereotaxic and prepared for nanoinjections (100 nl) of saline (NaCl 0.9%), Ang-(1–7) (40 ng) or Ang II (40 ng) into the RVLM. The vascular resistance (VR)was calculated by ΔMAP/ΔBF ratio. In WT, Ang-(1–7) or Ang II caused equipotent pressor effects that were not accompanied by changes in vascular resistance. However, MAP changes were greater in SHR. This strain also showed a concomitant increase in relative vascular resistance (ΔVR/VRbaseline) of renal (0.31 ± 0.07 and 0.3 ± 0.07 vs. 0.02 ± 0.01; Ang-(1–7), Ang II and Saline, respectively) and mesenteric beds (0.3 ± 0.06 and 0.33 ± 0.04 vs. 0.05 ± 0.02; Ang-(1–7), Ang II and saline, respectively). We conclude that Ang II and Ang-(1–7) at the RVLM control the vascular resistance of renal and mesenteric beds during hypertension.O periódico Neuropeptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894771218803.info:eu-repo/semantics/openAccessRostral ventrolateral medullaArterial pressureVascular blood flowSpontaneously hypertensive ratsDifferential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/6620/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_DifferentialControlVasomotion.pdfARTIGO_DifferentialControlVasomotion.pdfapplication/pdf923792http://www.repositorio.ufop.br/bitstream/123456789/6620/1/ARTIGO_DifferentialControlVasomotion.pdf67178b96f2b769d265af4012a373098bMD51123456789/66202019-09-20 10:41:52.26oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-09-20T14:41:52Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
title |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
spellingShingle |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. Ferreira, Patrícia Maria Rostral ventrolateral medulla Arterial pressure Vascular blood flow Spontaneously hypertensive rats |
title_short |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
title_full |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
title_fullStr |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
title_full_unstemmed |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
title_sort |
Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. |
author |
Ferreira, Patrícia Maria |
author_facet |
Ferreira, Patrícia Maria Custódio, Carlos Henrique Xavier Alzamora, Andréia Carvalho Santos, Robson Augusto Souza dos Santos, Maria José Campagnole dos |
author_role |
author |
author2 |
Custódio, Carlos Henrique Xavier Alzamora, Andréia Carvalho Santos, Robson Augusto Souza dos Santos, Maria José Campagnole dos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Patrícia Maria Custódio, Carlos Henrique Xavier Alzamora, Andréia Carvalho Santos, Robson Augusto Souza dos Santos, Maria José Campagnole dos |
dc.subject.por.fl_str_mv |
Rostral ventrolateral medulla Arterial pressure Vascular blood flow Spontaneously hypertensive rats |
topic |
Rostral ventrolateral medulla Arterial pressure Vascular blood flow Spontaneously hypertensive rats |
description |
The central and peripheral renin–angiotensin systems are known for playing a key role in cardiovascular control. In the present study,we evaluated the hemodynamic effects produced by nanoinjections of angiotensin II (Ang II) or angiotensin-(1–7) [Ang-(1–7)] into the rostral ventrolateral medulla (RVLM) of adult male normotensive (Wistar—WT) and spontaneously hypertensive rats (SHR). Animals were anesthetized (urethane 1.2 g/kg) and instrumented for recording blood pressure (BP), heart rate (HR) and blood flow (BF) in the femoral, renal or mesenteric arteries. Afterwards, rats were positioned in a stereotaxic and prepared for nanoinjections (100 nl) of saline (NaCl 0.9%), Ang-(1–7) (40 ng) or Ang II (40 ng) into the RVLM. The vascular resistance (VR)was calculated by ΔMAP/ΔBF ratio. In WT, Ang-(1–7) or Ang II caused equipotent pressor effects that were not accompanied by changes in vascular resistance. However, MAP changes were greater in SHR. This strain also showed a concomitant increase in relative vascular resistance (ΔVR/VRbaseline) of renal (0.31 ± 0.07 and 0.3 ± 0.07 vs. 0.02 ± 0.01; Ang-(1–7), Ang II and Saline, respectively) and mesenteric beds (0.3 ± 0.06 and 0.33 ± 0.04 vs. 0.05 ± 0.02; Ang-(1–7), Ang II and saline, respectively). We conclude that Ang II and Ang-(1–7) at the RVLM control the vascular resistance of renal and mesenteric beds during hypertension. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-07-25T16:18:43Z |
dc.date.available.fl_str_mv |
2016-07-25T16:18:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, P. M. et al. Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. Neuropeptides, Edinburgh, v. 1, p. 00-00, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0143417915000918>. Acesso em: 16 jun. 2016. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/6620 |
dc.identifier.issn.none.fl_str_mv |
0143-4179 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.npep.2015.09.002 |
identifier_str_mv |
FERREIRA, P. M. et al. Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats. Neuropeptides, Edinburgh, v. 1, p. 00-00, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0143417915000918>. Acesso em: 16 jun. 2016. 0143-4179 |
url |
http://www.repositorio.ufop.br/handle/123456789/6620 https://doi.org/10.1016/j.npep.2015.09.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
bitstream.url.fl_str_mv |
http://www.repositorio.ufop.br/bitstream/123456789/6620/2/license.txt http://www.repositorio.ufop.br/bitstream/123456789/6620/1/ARTIGO_DifferentialControlVasomotion.pdf |
bitstream.checksum.fl_str_mv |
62604f8d955274beb56c80ce1ee5dcae 67178b96f2b769d265af4012a373098b |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1801685790679367680 |