ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz.

• Autor(a) principal: Lucas Filho, Milton Dayrell
• Data de Publicação: 2010
• Outros Autores: Silva, Grazielle Caroline da, Côrtes, Steyner de França, Guia, Thiago Rennó dos Mares, Ferraz, Vany Perpetua, Serra, Carla Penido, Braga, Fernão Castro
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1214
• topic: Astilbin; Erythroxylum gonocladum; In vitro angiotensin converting enzyme inhibitory activity

Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.