Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.

Detalhes bibliográficos
Autor(a) principal: Câmara, Diógenes Vadim
Data de Publicação: 2010
Outros Autores: Lemos, Virgínia Soares, Santos, Marcelo Henrique dos, Nagem, Tanus Jorge, Côrtes, Steyner de França
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/762
Resumo: Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
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spelling Câmara, Diógenes VadimLemos, Virgínia SoaresSantos, Marcelo Henrique dosNagem, Tanus JorgeCôrtes, Steyner de França2012-05-22T20:29:01Z2012-05-22T20:29:01Z2010CÂMARA, D. V. et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine, v. 17, n. 8-9, p. 690-692, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S094471130900333X>. Acesso em: 22 maio 2012.09447113http://www.repositorio.ufop.br/handle/123456789/762Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.XanthoneProtein kinase CResistance arteryVasodilatationMechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3490231006877.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPORIGINALARTIGO_MechanismVasodilatorEffect.pdfARTIGO_MechanismVasodilatorEffect.pdfapplication/pdf246581http://www.repositorio.ufop.br/bitstream/123456789/762/6/ARTIGO_MechanismVasodilatorEffect.pdf7d5bfa33bdeab754253b8d8c364c9618MD56LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/762/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55123456789/7622019-02-25 09:33:50.207oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-25T14:33:50Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
title Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
spellingShingle Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
Câmara, Diógenes Vadim
Xanthone
Protein kinase C
Resistance artery
Vasodilatation
title_short Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
title_full Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
title_fullStr Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
title_full_unstemmed Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
title_sort Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
author Câmara, Diógenes Vadim
author_facet Câmara, Diógenes Vadim
Lemos, Virgínia Soares
Santos, Marcelo Henrique dos
Nagem, Tanus Jorge
Côrtes, Steyner de França
author_role author
author2 Lemos, Virgínia Soares
Santos, Marcelo Henrique dos
Nagem, Tanus Jorge
Côrtes, Steyner de França
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Câmara, Diógenes Vadim
Lemos, Virgínia Soares
Santos, Marcelo Henrique dos
Nagem, Tanus Jorge
Côrtes, Steyner de França
dc.subject.por.fl_str_mv Xanthone
Protein kinase C
Resistance artery
Vasodilatation
topic Xanthone
Protein kinase C
Resistance artery
Vasodilatation
description Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-05-22T20:29:01Z
dc.date.available.fl_str_mv 2012-05-22T20:29:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CÂMARA, D. V. et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine, v. 17, n. 8-9, p. 690-692, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S094471130900333X>. Acesso em: 22 maio 2012.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/762
dc.identifier.issn.none.fl_str_mv 09447113
identifier_str_mv CÂMARA, D. V. et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine, v. 17, n. 8-9, p. 690-692, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S094471130900333X>. Acesso em: 22 maio 2012.
09447113
url http://www.repositorio.ufop.br/handle/123456789/762
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
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