Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.

Detalhes bibliográficos
Autor(a) principal: Carvalho, Mayara Medeiros de Freitas
Data de Publicação: 2018
Outros Autores: Reis, Larissa Lélis Teixeira, Lopes, Juliana Márcia Macedo, Lage, Nara Nunes, Guerra, Joyce Ferreira da Costa, Zago, Helena Porto, Bonomo, Larissa de Freitas, Pereira, Renata Rebeca, Lima, Wanderson Geraldo de, Silva, Marcelo Eustáquio, Pedrosa, Maria Lúcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/10992
Resumo: Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Açai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action. Objective: we evaluated the benefits of açai supplementation on liver damage caused by replacing starch with fructose in rats. Methods: thirty male Fischer rats were divided into two groups, the control group (C, 10 animals), which consumed a standard diet (AIN-93M), and the fructose (F, 20 animals) group, which consumed a diet containing 60% of fructose. After eight weeks, 10 animals from the fructose group received 2% of lyophilized açai, and were called the açai fructose group (FA). The animals were fed ad libitum with these diets for another ten weeks. Serum, hepatic and fecal lipid profile, antioxidant enzymes and carbonylated protein were assessed and histopathological characterization of the liver was performed. Results: açai promoted the reduction of ALT activity in relation to the fructose group (F), reduced alkaline phosphatase to a level similar to that of the control group (C) in relation to the fructose group (F), and reduced catalase activity. The fruit also increased the ratio of total/oxidized glutathione (GSH/GSSG) and reduced the degree of macrovesicular steatosis and the number of inflammatory cells. Conclusion: the replacement of starch by fructose during this period was effective in promoting NAFLD. Açai showed attenuating effects on some markers of hepatic steatosis and inflammation.
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spelling Carvalho, Mayara Medeiros de FreitasReis, Larissa Lélis TeixeiraLopes, Juliana Márcia MacedoLage, Nara NunesGuerra, Joyce Ferreira da CostaZago, Helena PortoBonomo, Larissa de FreitasPereira, Renata RebecaLima, Wanderson Geraldo deSilva, Marcelo EustáquioPedrosa, Maria Lúcia2019-04-09T15:48:17Z2019-04-09T15:48:17Z2018CARVALHO, M. M. de F. et al. Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. Nutrición Hospitalaria, v. 35, n. 2, p. 318-325, 2018. Disponível em: <https://www.nutricionhospitalaria.org/index.php/articles/01294/show>. Acesso em: 25 fev. 2019.16995198http://www.repositorio.ufop.br/handle/123456789/10992Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Açai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action. Objective: we evaluated the benefits of açai supplementation on liver damage caused by replacing starch with fructose in rats. Methods: thirty male Fischer rats were divided into two groups, the control group (C, 10 animals), which consumed a standard diet (AIN-93M), and the fructose (F, 20 animals) group, which consumed a diet containing 60% of fructose. After eight weeks, 10 animals from the fructose group received 2% of lyophilized açai, and were called the açai fructose group (FA). The animals were fed ad libitum with these diets for another ten weeks. Serum, hepatic and fecal lipid profile, antioxidant enzymes and carbonylated protein were assessed and histopathological characterization of the liver was performed. Results: açai promoted the reduction of ALT activity in relation to the fructose group (F), reduced alkaline phosphatase to a level similar to that of the control group (C) in relation to the fructose group (F), and reduced catalase activity. The fruit also increased the ratio of total/oxidized glutathione (GSH/GSSG) and reduced the degree of macrovesicular steatosis and the number of inflammatory cells. Conclusion: the replacement of starch by fructose during this period was effective in promoting NAFLD. Açai showed attenuating effects on some markers of hepatic steatosis and inflammation.Introducción: el consumo excesivo de fructosa puede causar daño hepático, característico de la enfermedad hepática grasa no alcohólica (EHGNA), asociada con cambios en el metabolismo de los lípidos y defensas antioxidantes. El açai, fruto del Euterpe oleracea Mart., ha demostrado desempeñar numerosas actividades biológicas, incluidas acciones antiinflamatorias, antioxidantes y moduladoras del metabolismo lipídico. Objetivo: se evaluaron los beneficios de la suplementación con açai en el daño hepático causado por la sustitución del almidón por fructosa en ratas. Métodos: se distribuyeron 30 ratas Fischer macho en dos grupos: 10 ratas en el grupo control (C), que consumía una dieta estándar (AIN-93M), y 20 ratas en el grupo fructosa (F), que consumía una dieta que contenía un 60% de fructosa. Después de ocho semanas, diez animales del grupo fructosa recibieron un 2% de açai liofilizado, por lo que pasaron a integrar el grupo açai fructosa (FA). Los animales fueron alimentados ad libitum con estas dietas durante otras diez semanas. Se analizaron el perfil lipídico hepático y fecal, las enzimas antioxidantes y la proteína carbonilada, y se realizó la caracterización histopatológica del hígado. Resultados: el açai promovió la reducción de la actividad de ALT en relación al grupo de fructosa (F) y la reducción de la fosfatasa alcalina a niveles similares a los hallados en el grupo control (C) en relación con el grupo de fructosa (F). El fruto también aumentó la proporción de glutatión total/oxidado (GSH/GSSG) y redujo el grado de esteatosis macrovesicular y el número de células inflamatorias. Conclusión: la sustitución de almidón por fructosa durante este periodo fue eficaz en la promoción de NAFLD. El açai mostró efectos atenuantes en algunos marcadores de esteatosis hepática y de inflamación.Este es un artículo Open Access bajo la licencia CC BY-NC-SA (http://creativecommons.org/licenses/by-nc-sa/4.0/). Fonte: O próprio artigo.info:eu-repo/semantics/openAccessEuterpe oleraceaMart. Fructose-dietHepatic steatosisInflammationAntioxidant enzymes.Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.El açai mejora la enfermedad de hígado graso no alcohólico (NAFLD) inducida por la fructosa.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/10992/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_AçaiImprovesAlcoholic.pdfARTIGO_AçaiImprovesAlcoholic.pdfapplication/pdf1433368http://www.repositorio.ufop.br/bitstream/123456789/10992/1/ARTIGO_A%c3%a7aiImprovesAlcoholic.pdfe1181615eaaca1e4384ba52863bccc8fMD51123456789/109922019-04-09 11:48:17.937oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-09T15:48:17Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
dc.title.alternative.pt_BR.fl_str_mv El açai mejora la enfermedad de hígado graso no alcohólico (NAFLD) inducida por la fructosa.
title Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
spellingShingle Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
Carvalho, Mayara Medeiros de Freitas
Euterpe oleracea
Mart. Fructose-diet
Hepatic steatosis
Inflammation
Antioxidant enzymes.
title_short Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
title_full Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
title_fullStr Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
title_full_unstemmed Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
title_sort Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose.
author Carvalho, Mayara Medeiros de Freitas
author_facet Carvalho, Mayara Medeiros de Freitas
Reis, Larissa Lélis Teixeira
Lopes, Juliana Márcia Macedo
Lage, Nara Nunes
Guerra, Joyce Ferreira da Costa
Zago, Helena Porto
Bonomo, Larissa de Freitas
Pereira, Renata Rebeca
Lima, Wanderson Geraldo de
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
author_role author
author2 Reis, Larissa Lélis Teixeira
Lopes, Juliana Márcia Macedo
Lage, Nara Nunes
Guerra, Joyce Ferreira da Costa
Zago, Helena Porto
Bonomo, Larissa de Freitas
Pereira, Renata Rebeca
Lima, Wanderson Geraldo de
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Mayara Medeiros de Freitas
Reis, Larissa Lélis Teixeira
Lopes, Juliana Márcia Macedo
Lage, Nara Nunes
Guerra, Joyce Ferreira da Costa
Zago, Helena Porto
Bonomo, Larissa de Freitas
Pereira, Renata Rebeca
Lima, Wanderson Geraldo de
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
dc.subject.por.fl_str_mv Euterpe oleracea
Mart. Fructose-diet
Hepatic steatosis
Inflammation
Antioxidant enzymes.
topic Euterpe oleracea
Mart. Fructose-diet
Hepatic steatosis
Inflammation
Antioxidant enzymes.
description Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Açai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action. Objective: we evaluated the benefits of açai supplementation on liver damage caused by replacing starch with fructose in rats. Methods: thirty male Fischer rats were divided into two groups, the control group (C, 10 animals), which consumed a standard diet (AIN-93M), and the fructose (F, 20 animals) group, which consumed a diet containing 60% of fructose. After eight weeks, 10 animals from the fructose group received 2% of lyophilized açai, and were called the açai fructose group (FA). The animals were fed ad libitum with these diets for another ten weeks. Serum, hepatic and fecal lipid profile, antioxidant enzymes and carbonylated protein were assessed and histopathological characterization of the liver was performed. Results: açai promoted the reduction of ALT activity in relation to the fructose group (F), reduced alkaline phosphatase to a level similar to that of the control group (C) in relation to the fructose group (F), and reduced catalase activity. The fruit also increased the ratio of total/oxidized glutathione (GSH/GSSG) and reduced the degree of macrovesicular steatosis and the number of inflammatory cells. Conclusion: the replacement of starch by fructose during this period was effective in promoting NAFLD. Açai showed attenuating effects on some markers of hepatic steatosis and inflammation.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-04-09T15:48:17Z
dc.date.available.fl_str_mv 2019-04-09T15:48:17Z
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dc.identifier.citation.fl_str_mv CARVALHO, M. M. de F. et al. Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. Nutrición Hospitalaria, v. 35, n. 2, p. 318-325, 2018. Disponível em: <https://www.nutricionhospitalaria.org/index.php/articles/01294/show>. Acesso em: 25 fev. 2019.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/10992
dc.identifier.issn.none.fl_str_mv 16995198
identifier_str_mv CARVALHO, M. M. de F. et al. Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. Nutrición Hospitalaria, v. 35, n. 2, p. 318-325, 2018. Disponível em: <https://www.nutricionhospitalaria.org/index.php/articles/01294/show>. Acesso em: 25 fev. 2019.
16995198
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