Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia

Detalhes bibliográficos
Autor(a) principal: Polita, Sandra Lermen
Data de Publicação: 2021
Outros Autores: Massuda, Raffael, Panizzutti, Bruna Schilling, Gama, Clarissa Severino, Duarte, Juliana Avila
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/106797
Resumo: Introduction: It is well established that cortical volume are decreased in patientswith schizophrenia. One possible explanation is that the increased pro-inflammatorystatus in schizophrenia is related to volumetric decrease of gray matter. The aim ofthis study was to correlate interleukin 6 (IL-6) with cortical volume in patients withschizophrenia and controls.Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6(IL-6) was correlated with cortical volume in patients with schizophrenia and controls.Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370)in patients, but not in controls (p = 0.235).Discussion: Our results are in line with previous studies suggesting that chronicinflammatory activation in patients with schizophrenia could be one plausible mechanismthat could contribute for the cortical volumetric decrease often seen in this population.However, this cross-sectional study with a small number of patients does not allowus to establish causal relations.
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spelling Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophreniaSchizophreniaInflammationMRIIntroduction: It is well established that cortical volume are decreased in patientswith schizophrenia. One possible explanation is that the increased pro-inflammatorystatus in schizophrenia is related to volumetric decrease of gray matter. The aim ofthis study was to correlate interleukin 6 (IL-6) with cortical volume in patients withschizophrenia and controls.Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6(IL-6) was correlated with cortical volume in patients with schizophrenia and controls.Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370)in patients, but not in controls (p = 0.235).Discussion: Our results are in line with previous studies suggesting that chronicinflammatory activation in patients with schizophrenia could be one plausible mechanismthat could contribute for the cortical volumetric decrease often seen in this population.However, this cross-sectional study with a small number of patients does not allowus to establish causal relations.HCPA/FAMED/UFRGS2021-10-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/106797Clinical & Biomedical Research; Vol. 41 No. 3 (2021): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 41 n. 3 (2021): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/106797/pdfCopyright (c) 2021 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessPolita, Sandra LermenMassuda, RaffaelPanizzutti, Bruna SchillingGama, Clarissa SeverinoDuarte, Juliana Avila2024-01-19T14:13:25Zoai:seer.ufrgs.br:article/106797Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:13:25Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
title Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
spellingShingle Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
Polita, Sandra Lermen
Schizophrenia
Inflammation
MRI
title_short Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
title_full Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
title_fullStr Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
title_full_unstemmed Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
title_sort Cortical volume is inversely correlated with Interleukin-6 serum levels in patients with schizophrenia
author Polita, Sandra Lermen
author_facet Polita, Sandra Lermen
Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Avila
author_role author
author2 Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Avila
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Polita, Sandra Lermen
Massuda, Raffael
Panizzutti, Bruna Schilling
Gama, Clarissa Severino
Duarte, Juliana Avila
dc.subject.por.fl_str_mv Schizophrenia
Inflammation
MRI
topic Schizophrenia
Inflammation
MRI
description Introduction: It is well established that cortical volume are decreased in patientswith schizophrenia. One possible explanation is that the increased pro-inflammatorystatus in schizophrenia is related to volumetric decrease of gray matter. The aim ofthis study was to correlate interleukin 6 (IL-6) with cortical volume in patients withschizophrenia and controls.Methods: We selected 36 patients with schizophrenia and 35 controls. Interleukin 6(IL-6) was correlated with cortical volume in patients with schizophrenia and controls.Results: IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370)in patients, but not in controls (p = 0.235).Discussion: Our results are in line with previous studies suggesting that chronicinflammatory activation in patients with schizophrenia could be one plausible mechanismthat could contribute for the cortical volumetric decrease often seen in this population.However, this cross-sectional study with a small number of patients does not allowus to establish causal relations.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/106797
url https://seer.ufrgs.br/index.php/hcpa/article/view/106797
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/106797/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2021 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 41 No. 3 (2021): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 41 n. 3 (2021): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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