Does comorbid bipolar disorder increase neuropsychological impairment in children and adolescents with ADHD?

• Autor(a) principal: Narvaez, Joana Corrêa de Magalhães
• Data de Publicação: 2014
• Outros Autores: Zeni, Cristian Patrick, Coelho, Roberta Paula Schell, Wagner, Flávia, Pheula, Gabriel Ferreira, Souza, Carla Ruffoni Ketzer de, Trentini, Clarissa Marceli, Tramontina, Silzá, Rohde, Luis Augusto Paim
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/116916
• topic: Transtorno do déficit de atenção com hiperatividade; Transtorno bipolar; Criança; Adolescente; Neuropsicologia; ADHD; Bipolar disorder; Children; Neuropsychology

Objective: To assess differences in executive functioning between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) comorbid or not with bipolar disorder (BD), and to study the neuropsychological profile of subjects with the comorbidity in a clinical sample from a developing country. Method: Case-control study comparing 23 participants with BD + ADHD and 85 ADHD-only subjects aged 6 to 17 years old. Both groups were drug-free. Executive function domains were assessed with the Stroop Test, the Wisconsin Card Sorting Test, and the Continuous Performance Test II. Results: The group with juvenile BD + ADHD showed a significantly worse performance on the Stroop task, including time in color (p = 0.002), time in color-word (p , 0.001), interference, number or errors in color and color-word (p = 0.001), and number of errors in word cards (p = 0.028). No between-group differences were found in other tests. Conclusions: Our findings suggest that ADHD-only and ADHD + BD do not show differences in inhibitory control and set-shifting domains. However, children and adolescents with BD and comorbid ADHD show greater impairment in processing speed and interference control. This suggests a potentially higher impairment in the dorsolateral prefrontal cortex and may be a potential neuropsychological signature of juvenile BD comorbid with ADHD.