Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/203817 |
Resumo: | Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na+, K+-ATPase activity. Wistar rats were divided into non-diabetic groups: Control, Ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. Diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na+, K+-ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients. |
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Kolling, JeniferKolling, JanaínaFranceschi, Itiane Diehl deNishihira, Vivian Shinobu KishimotoBaldissera, Matheus DellaméaPinto, Claudia GrigoloMezzomo, Nathana JamilleCarmo, Guilherme Machado doFeksa, Luciane RosaFernandes, Liana da SilvaOliveira, Gilberto Orengo deVaucher, Rodrigo de AlmeidaGiongo, Janice LuehringWyse, Angela Terezinha de SouzaWannmacher, Clovis Milton DuvalRech, Virgínia Cielo2019-12-27T04:03:24Z20190001-3765http://hdl.handle.net/10183/203817001104171Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na+, K+-ATPase activity. Wistar rats were divided into non-diabetic groups: Control, Ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. Diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na+, K+-ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients.application/pdfengAnais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 91, no. 3 (Sep. 2019), e20181330, 12 p.Diabetes mellitusResveratrol2-Hidroxipropil-beta-CiclodextrinaEnergy metabolismHydroxypropyl-β-cyclodextrinHyperglycemiaNanotecnologyResveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic ratsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001104171.pdf.txt001104171.pdf.txtExtracted Texttext/plain45083http://www.lume.ufrgs.br/bitstream/10183/203817/2/001104171.pdf.txt9d2f6307adc2f90c5b689349d1ea430eMD52ORIGINAL001104171.pdfTexto completo (inglês)application/pdf1711209http://www.lume.ufrgs.br/bitstream/10183/203817/1/001104171.pdf0f3ad0fbc324fe5e8aeba69780fe4182MD5110183/2038172023-07-08 03:34:29.097427oai:www.lume.ufrgs.br:10183/203817Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-08T06:34:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
title |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
spellingShingle |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats Kolling, Jenifer Diabetes mellitus Resveratrol 2-Hidroxipropil-beta-Ciclodextrina Energy metabolism Hydroxypropyl-β-cyclodextrin Hyperglycemia Nanotecnology |
title_short |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
title_full |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
title_fullStr |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
title_full_unstemmed |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
title_sort |
Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats |
author |
Kolling, Jenifer |
author_facet |
Kolling, Jenifer Kolling, Janaína Franceschi, Itiane Diehl de Nishihira, Vivian Shinobu Kishimoto Baldissera, Matheus Dellaméa Pinto, Claudia Grigolo Mezzomo, Nathana Jamille Carmo, Guilherme Machado do Feksa, Luciane Rosa Fernandes, Liana da Silva Oliveira, Gilberto Orengo de Vaucher, Rodrigo de Almeida Giongo, Janice Luehring Wyse, Angela Terezinha de Souza Wannmacher, Clovis Milton Duval Rech, Virgínia Cielo |
author_role |
author |
author2 |
Kolling, Janaína Franceschi, Itiane Diehl de Nishihira, Vivian Shinobu Kishimoto Baldissera, Matheus Dellaméa Pinto, Claudia Grigolo Mezzomo, Nathana Jamille Carmo, Guilherme Machado do Feksa, Luciane Rosa Fernandes, Liana da Silva Oliveira, Gilberto Orengo de Vaucher, Rodrigo de Almeida Giongo, Janice Luehring Wyse, Angela Terezinha de Souza Wannmacher, Clovis Milton Duval Rech, Virgínia Cielo |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kolling, Jenifer Kolling, Janaína Franceschi, Itiane Diehl de Nishihira, Vivian Shinobu Kishimoto Baldissera, Matheus Dellaméa Pinto, Claudia Grigolo Mezzomo, Nathana Jamille Carmo, Guilherme Machado do Feksa, Luciane Rosa Fernandes, Liana da Silva Oliveira, Gilberto Orengo de Vaucher, Rodrigo de Almeida Giongo, Janice Luehring Wyse, Angela Terezinha de Souza Wannmacher, Clovis Milton Duval Rech, Virgínia Cielo |
dc.subject.por.fl_str_mv |
Diabetes mellitus Resveratrol 2-Hidroxipropil-beta-Ciclodextrina |
topic |
Diabetes mellitus Resveratrol 2-Hidroxipropil-beta-Ciclodextrina Energy metabolism Hydroxypropyl-β-cyclodextrin Hyperglycemia Nanotecnology |
dc.subject.eng.fl_str_mv |
Energy metabolism Hydroxypropyl-β-cyclodextrin Hyperglycemia Nanotecnology |
description |
Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na+, K+-ATPase activity. Wistar rats were divided into non-diabetic groups: Control, Ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. Diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na+, K+-ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-12-27T04:03:24Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/203817 |
dc.identifier.issn.pt_BR.fl_str_mv |
0001-3765 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001104171 |
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url |
http://hdl.handle.net/10183/203817 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Anais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 91, no. 3 (Sep. 2019), e20181330, 12 p. |
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info:eu-repo/semantics/openAccess |
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