The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267627 |
Resumo: | Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic (PHE) and terpenoid (SAP) compounds from B. trimera on human cervical cancer. The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility. Although SAP inhibited the proliferation of SiHa cells in a dose-dependent manner, it increased colony formation and did not inhibit cell motility. PHE and SAP also promoted a significant increase in lactate dehydrogenase levels in the culture medium in a dose-dependent manner, indicating a loss of cell membrane integrity. Moreover, PHE promoted necrotic cell death, whereas SAP induced apoptosis. These compounds are new anticancer prototypes due their significant anticancer activity demonstrated herein. |
id |
UFRGS-2_10fe4d5ff958d27dc38f76c244cbeaaf |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/267627 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Oliveira, Cristiane Bernardes deComunello, Lucimara NardiMaciel, Érica SantosGiubel, Scheron RathkeBruno, Alessandra NejarChiela, Eduardo Cremonese FilippiLenz, GuidoGnoatto, Simone Cristina BaggioBuffon, AndreiaGosmann, Grace2023-11-25T03:26:27Z20131420-3049http://hdl.handle.net/10183/267627000910885Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic (PHE) and terpenoid (SAP) compounds from B. trimera on human cervical cancer. The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility. Although SAP inhibited the proliferation of SiHa cells in a dose-dependent manner, it increased colony formation and did not inhibit cell motility. PHE and SAP also promoted a significant increase in lactate dehydrogenase levels in the culture medium in a dose-dependent manner, indicating a loss of cell membrane integrity. Moreover, PHE promoted necrotic cell death, whereas SAP induced apoptosis. These compounds are new anticancer prototypes due their significant anticancer activity demonstrated herein.application/pdfengMolecules. Basel, Switzerland. Vol. 18, n. 9 (Sep. 2013), p. 11022-11032Baccharis trimeraTerpenóidesCompostos fenólicosNeoplasias do colo do úteroPhenolic compoundsTerpenoidsCervical cancerNecrosisApoptosisThe inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of actionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000910885.pdf.txt000910885.pdf.txtExtracted Texttext/plain25366http://www.lume.ufrgs.br/bitstream/10183/267627/2/000910885.pdf.txt91fa1e4c7d3354bdc36ebb336c9fc8b2MD52ORIGINAL000910885.pdfTexto completo (inglês)application/pdf476787http://www.lume.ufrgs.br/bitstream/10183/267627/1/000910885.pdfe29f88991d945304cbffc4a3a4da91c4MD5110183/2676272023-12-06 04:24:49.429357oai:www.lume.ufrgs.br:10183/267627Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-12-06T06:24:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
title |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
spellingShingle |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action Oliveira, Cristiane Bernardes de Baccharis trimera Terpenóides Compostos fenólicos Neoplasias do colo do útero Phenolic compounds Terpenoids Cervical cancer Necrosis Apoptosis |
title_short |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
title_full |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
title_fullStr |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
title_full_unstemmed |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
title_sort |
The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in siha cells : differences in their activity and mechanism of action |
author |
Oliveira, Cristiane Bernardes de |
author_facet |
Oliveira, Cristiane Bernardes de Comunello, Lucimara Nardi Maciel, Érica Santos Giubel, Scheron Rathke Bruno, Alessandra Nejar Chiela, Eduardo Cremonese Filippi Lenz, Guido Gnoatto, Simone Cristina Baggio Buffon, Andreia Gosmann, Grace |
author_role |
author |
author2 |
Comunello, Lucimara Nardi Maciel, Érica Santos Giubel, Scheron Rathke Bruno, Alessandra Nejar Chiela, Eduardo Cremonese Filippi Lenz, Guido Gnoatto, Simone Cristina Baggio Buffon, Andreia Gosmann, Grace |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Cristiane Bernardes de Comunello, Lucimara Nardi Maciel, Érica Santos Giubel, Scheron Rathke Bruno, Alessandra Nejar Chiela, Eduardo Cremonese Filippi Lenz, Guido Gnoatto, Simone Cristina Baggio Buffon, Andreia Gosmann, Grace |
dc.subject.por.fl_str_mv |
Baccharis trimera Terpenóides Compostos fenólicos Neoplasias do colo do útero |
topic |
Baccharis trimera Terpenóides Compostos fenólicos Neoplasias do colo do útero Phenolic compounds Terpenoids Cervical cancer Necrosis Apoptosis |
dc.subject.eng.fl_str_mv |
Phenolic compounds Terpenoids Cervical cancer Necrosis Apoptosis |
description |
Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are related to the presence of phenolic compounds. The aim of this work was to investigate the anti-proliferative properties of phenolic (PHE) and terpenoid (SAP) compounds from B. trimera on human cervical cancer. The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility. Although SAP inhibited the proliferation of SiHa cells in a dose-dependent manner, it increased colony formation and did not inhibit cell motility. PHE and SAP also promoted a significant increase in lactate dehydrogenase levels in the culture medium in a dose-dependent manner, indicating a loss of cell membrane integrity. Moreover, PHE promoted necrotic cell death, whereas SAP induced apoptosis. These compounds are new anticancer prototypes due their significant anticancer activity demonstrated herein. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2023-11-25T03:26:27Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267627 |
dc.identifier.issn.pt_BR.fl_str_mv |
1420-3049 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000910885 |
identifier_str_mv |
1420-3049 000910885 |
url |
http://hdl.handle.net/10183/267627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Molecules. Basel, Switzerland. Vol. 18, n. 9 (Sep. 2013), p. 11022-11032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/267627/2/000910885.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/267627/1/000910885.pdf |
bitstream.checksum.fl_str_mv |
91fa1e4c7d3354bdc36ebb336c9fc8b2 e29f88991d945304cbffc4a3a4da91c4 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225105675649024 |