Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/215356 |
Resumo: | Significance: Four decades have passed since the first successful humanembryo conceived froma fertilization in vitro. Despite all advances, success rates in assisted reproduction techniques still remain unsatisfactory and it is well established that oxidative stress can be one of themajor factors causing failure in in vitro fertilization (IVF) techniques. Recent Advances: In the past years, researchers have been shown details of the supportive role CCs play along oocyte maturation, development, and fertilization processes. Regarding redox metabolism, it is now evident that the synergism between gamete and somatic CCs is fundamental to further support a healthy embryo, since the oocyte lacks several defense mechanisms that are provided by the CCs. Critical Issues: There are many sources of reactive oxygen species (ROS) in the female reproductive tract in vivo that can be exacerbated (or aggravated) by pathological features. While an imbalance between ROS and antioxidants can result in oxidative damage, physiological levels of ROS are essential for oocyte maturation, ovulation, and early embryonic growth where they act as signaling molecules. At the event of an assisted reproduction procedure, the cumulus/oophorus complex is exposed to additional sources of oxidative stress in vitro. The cumulus cells (CCs) play essential roles in protecting the oocytes from oxidative damage. Future Directions: More studies are needed to elucidate redox biology in human CCs and oocyte. Also, randomized controlled trials will identify possible benefits of in vivo or in vitro administration of antioxidants for patients seeking IVF procedure |
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Meirelles, Lúcia von MengdenKlamt, FabioSmitz, Johan2020-11-21T04:25:49Z20201523-0864http://hdl.handle.net/10183/215356001118494Significance: Four decades have passed since the first successful humanembryo conceived froma fertilization in vitro. Despite all advances, success rates in assisted reproduction techniques still remain unsatisfactory and it is well established that oxidative stress can be one of themajor factors causing failure in in vitro fertilization (IVF) techniques. Recent Advances: In the past years, researchers have been shown details of the supportive role CCs play along oocyte maturation, development, and fertilization processes. Regarding redox metabolism, it is now evident that the synergism between gamete and somatic CCs is fundamental to further support a healthy embryo, since the oocyte lacks several defense mechanisms that are provided by the CCs. Critical Issues: There are many sources of reactive oxygen species (ROS) in the female reproductive tract in vivo that can be exacerbated (or aggravated) by pathological features. While an imbalance between ROS and antioxidants can result in oxidative damage, physiological levels of ROS are essential for oocyte maturation, ovulation, and early embryonic growth where they act as signaling molecules. At the event of an assisted reproduction procedure, the cumulus/oophorus complex is exposed to additional sources of oxidative stress in vitro. The cumulus cells (CCs) play essential roles in protecting the oocytes from oxidative damage. Future Directions: More studies are needed to elucidate redox biology in human CCs and oocyte. Also, randomized controlled trials will identify possible benefits of in vivo or in vitro administration of antioxidants for patients seeking IVF procedureapplication/pdfengAntioxidants & redox signaling. Larchmont. Vol. 32, no. 8 (Feb. 2020), p. 522-535Fertilização in vitroCélulas do cúmuloEspécies reativas de oxigênioOócitosCumulus cellsRedoxAntioxidantInfertilityOocyteIVFRedox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical useEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001118494.pdf.txt001118494.pdf.txtExtracted Texttext/plain68723http://www.lume.ufrgs.br/bitstream/10183/215356/2/001118494.pdf.txta559b3259a778589c0a104d6c265fe5eMD52ORIGINAL001118494.pdfTexto completo (inglês)application/pdf562007http://www.lume.ufrgs.br/bitstream/10183/215356/1/001118494.pdf8a9a6d68411bd2cc38faef1c078bcae9MD5110183/2153562020-11-22 05:14:13.236974oai:www.lume.ufrgs.br:10183/215356Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-11-22T07:14:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
title |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
spellingShingle |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use Meirelles, Lúcia von Mengden Fertilização in vitro Células do cúmulo Espécies reativas de oxigênio Oócitos Cumulus cells Redox Antioxidant Infertility Oocyte IVF |
title_short |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
title_full |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
title_fullStr |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
title_full_unstemmed |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
title_sort |
Redox biology of human cumulus cells : basic concepts, impact on oocyte quality, and potential clinical use |
author |
Meirelles, Lúcia von Mengden |
author_facet |
Meirelles, Lúcia von Mengden Klamt, Fabio Smitz, Johan |
author_role |
author |
author2 |
Klamt, Fabio Smitz, Johan |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Meirelles, Lúcia von Mengden Klamt, Fabio Smitz, Johan |
dc.subject.por.fl_str_mv |
Fertilização in vitro Células do cúmulo Espécies reativas de oxigênio Oócitos |
topic |
Fertilização in vitro Células do cúmulo Espécies reativas de oxigênio Oócitos Cumulus cells Redox Antioxidant Infertility Oocyte IVF |
dc.subject.eng.fl_str_mv |
Cumulus cells Redox Antioxidant Infertility Oocyte IVF |
description |
Significance: Four decades have passed since the first successful humanembryo conceived froma fertilization in vitro. Despite all advances, success rates in assisted reproduction techniques still remain unsatisfactory and it is well established that oxidative stress can be one of themajor factors causing failure in in vitro fertilization (IVF) techniques. Recent Advances: In the past years, researchers have been shown details of the supportive role CCs play along oocyte maturation, development, and fertilization processes. Regarding redox metabolism, it is now evident that the synergism between gamete and somatic CCs is fundamental to further support a healthy embryo, since the oocyte lacks several defense mechanisms that are provided by the CCs. Critical Issues: There are many sources of reactive oxygen species (ROS) in the female reproductive tract in vivo that can be exacerbated (or aggravated) by pathological features. While an imbalance between ROS and antioxidants can result in oxidative damage, physiological levels of ROS are essential for oocyte maturation, ovulation, and early embryonic growth where they act as signaling molecules. At the event of an assisted reproduction procedure, the cumulus/oophorus complex is exposed to additional sources of oxidative stress in vitro. The cumulus cells (CCs) play essential roles in protecting the oocytes from oxidative damage. Future Directions: More studies are needed to elucidate redox biology in human CCs and oocyte. Also, randomized controlled trials will identify possible benefits of in vivo or in vitro administration of antioxidants for patients seeking IVF procedure |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-11-21T04:25:49Z |
dc.date.issued.fl_str_mv |
2020 |
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Estrangeiro info:eu-repo/semantics/article |
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001118494 |
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http://hdl.handle.net/10183/215356 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Antioxidants & redox signaling. Larchmont. Vol. 32, no. 8 (Feb. 2020), p. 522-535 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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