Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/256729 |
Resumo: | Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer’s Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [18F]florbetapir and [18F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [18F]FDG uptake, and RAVLT30 scores positively associated with [18F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake in the right frontal lobe. For the AD group, [18F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [18F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages. |
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Dauar, Marina TedeschiPascoal, Tharick AliTherriault, JosephRowley, JaredMohaddes, SaraShin, MonicaZimmer, Eduardo RigonEskildsen, Simon FristedFonov, Vladimir S.Gauthier, Serge G.Poirier, JudesRosa Neto, PedroAlzheimer’s Disease Neuroimaging Initiative2023-04-05T03:48:09Z20232076-3425http://hdl.handle.net/10183/256729001165442Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer’s Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [18F]florbetapir and [18F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [18F]FDG uptake, and RAVLT30 scores positively associated with [18F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake in the right frontal lobe. For the AD group, [18F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [18F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages.application/pdfengBrain sciences. Basel. Vol. 13, no. 2 (Feb. 2023), 232, 11 p.Doença de AlzheimerTestes de memória e aprendizagemEncefalopatiasAlzheimer’s diseaseMild cognitive impairmentFDG-PETAmyloid PETMemory testsDynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s diseaseEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001165442.pdf.txt001165442.pdf.txtExtracted Texttext/plain49103http://www.lume.ufrgs.br/bitstream/10183/256729/2/001165442.pdf.txt3e30af85bf8e5018f70b0183d7061d7aMD52ORIGINAL001165442.pdfTexto completo (inglês)application/pdf980652http://www.lume.ufrgs.br/bitstream/10183/256729/1/001165442.pdfde37415dd4750569298482e241025463MD5110183/2567292023-07-06 03:54:04.182366oai:www.lume.ufrgs.br:10183/256729Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-06T06:54:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
title |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
spellingShingle |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease Dauar, Marina Tedeschi Doença de Alzheimer Testes de memória e aprendizagem Encefalopatias Alzheimer’s disease Mild cognitive impairment FDG-PET Amyloid PET Memory tests |
title_short |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
title_full |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
title_fullStr |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
title_full_unstemmed |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
title_sort |
Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease |
author |
Dauar, Marina Tedeschi |
author_facet |
Dauar, Marina Tedeschi Pascoal, Tharick Ali Therriault, Joseph Rowley, Jared Mohaddes, Sara Shin, Monica Zimmer, Eduardo Rigon Eskildsen, Simon Fristed Fonov, Vladimir S. Gauthier, Serge G. Poirier, Judes Rosa Neto, Pedro |
author_role |
author |
author2 |
Pascoal, Tharick Ali Therriault, Joseph Rowley, Jared Mohaddes, Sara Shin, Monica Zimmer, Eduardo Rigon Eskildsen, Simon Fristed Fonov, Vladimir S. Gauthier, Serge G. Poirier, Judes Rosa Neto, Pedro |
author2_role |
author author author author author author author author author author author |
dc.contributor.other.pt_BR.fl_str_mv |
Alzheimer’s Disease Neuroimaging Initiative |
dc.contributor.author.fl_str_mv |
Dauar, Marina Tedeschi Pascoal, Tharick Ali Therriault, Joseph Rowley, Jared Mohaddes, Sara Shin, Monica Zimmer, Eduardo Rigon Eskildsen, Simon Fristed Fonov, Vladimir S. Gauthier, Serge G. Poirier, Judes Rosa Neto, Pedro |
dc.subject.por.fl_str_mv |
Doença de Alzheimer Testes de memória e aprendizagem Encefalopatias |
topic |
Doença de Alzheimer Testes de memória e aprendizagem Encefalopatias Alzheimer’s disease Mild cognitive impairment FDG-PET Amyloid PET Memory tests |
dc.subject.eng.fl_str_mv |
Alzheimer’s disease Mild cognitive impairment FDG-PET Amyloid PET Memory tests |
description |
Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer’s Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [18F]florbetapir and [18F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [18F]FDG uptake, and RAVLT30 scores positively associated with [18F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake in the right frontal lobe. For the AD group, [18F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [18F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-04-05T03:48:09Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/256729 |
dc.identifier.issn.pt_BR.fl_str_mv |
2076-3425 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001165442 |
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2076-3425 001165442 |
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http://hdl.handle.net/10183/256729 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brain sciences. Basel. Vol. 13, no. 2 (Feb. 2023), 232, 11 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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