A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients
Autor(a) principal: | |
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Data de Publicação: | 1990 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/247450 |
Resumo: | I. The effect of a 7-day low-protein diet on renal function was studied in 17 normotensive, normoalbuminuric, insulin-dependent diabetes mellitus (IDDM) patients. Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were measured after 7 days on an isocaloric low-protein diet (0.5 g protein/kg per day). 2. Compliance was confirmed by 24-h urinary urea levels. GFR was measured after a single injection of 5Icr-EDTA and UAE by radioimmunoassay. 3. GFR was reduced by 13.8% on the low-protein diet (139.9 ±27.7 vs 120.4 ±25.1 rn1 min-I (1.73 m2)-l) (P<0.05). This effect was of the same magnitude as that obtained by others after long-term strict metabolic control. No changes were observed in UAE (5.6 ± 6.4 vs 5.7 ± 6.8 f.Lg/min) during the study. The patients were classified as hyperfiltering (N = 9; GFR = 160.3 ± 16.6 rn1 min-I (1.73 m2)-l) or normofiltering (N = 8; GFR = 117.1 ± 17.6 ml min-I (1.73 m2)-l) on the basis ofGFR, and no difference in the reduction of GFR was observed in either group. 4. The reduction in GFR is probably caused primarily by the reduction of protein intake since other factors that might influence the GFR such as glucose control and blood pressure did not change during the study. |
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Azevedo, Mirela Jobim deGross, Jorge LuizPadilha, L.M.2022-08-19T04:45:35Z19900100-879Xhttp://hdl.handle.net/10183/247450000061265I. The effect of a 7-day low-protein diet on renal function was studied in 17 normotensive, normoalbuminuric, insulin-dependent diabetes mellitus (IDDM) patients. Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were measured after 7 days on an isocaloric low-protein diet (0.5 g protein/kg per day). 2. Compliance was confirmed by 24-h urinary urea levels. GFR was measured after a single injection of 5Icr-EDTA and UAE by radioimmunoassay. 3. GFR was reduced by 13.8% on the low-protein diet (139.9 ±27.7 vs 120.4 ±25.1 rn1 min-I (1.73 m2)-l) (P<0.05). This effect was of the same magnitude as that obtained by others after long-term strict metabolic control. No changes were observed in UAE (5.6 ± 6.4 vs 5.7 ± 6.8 f.Lg/min) during the study. The patients were classified as hyperfiltering (N = 9; GFR = 160.3 ± 16.6 rn1 min-I (1.73 m2)-l) or normofiltering (N = 8; GFR = 117.1 ± 17.6 ml min-I (1.73 m2)-l) on the basis ofGFR, and no difference in the reduction of GFR was observed in either group. 4. The reduction in GFR is probably caused primarily by the reduction of protein intake since other factors that might influence the GFR such as glucose control and blood pressure did not change during the study.application/pdfengBrazilian Journal of Medical and Biological Research. Ribeirao Preto. Vol. 23, no. 8 (1990), p. 647-654Diabetes mellitus tipo 1Dieta com restrição de proteínasTaxa de filtração glomerularInsulin-dependent diabetes mellitusLow-protein dietHyperfiltrationNormoalbuminuriaA short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patientsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000061265.pdf.txt000061265.pdf.txtExtracted Texttext/plain20779http://www.lume.ufrgs.br/bitstream/10183/247450/2/000061265.pdf.txt1a9ac97f9eef262f72f56bc4d18cbbb9MD52ORIGINAL000061265.pdfTexto completo (inglês)application/pdf2336913http://www.lume.ufrgs.br/bitstream/10183/247450/1/000061265.pdf7c9274a5ef8594c07bfc627eb88b4faaMD5110183/2474502022-08-21 04:39:13.603156oai:www.lume.ufrgs.br:10183/247450Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-08-21T07:39:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
title |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
spellingShingle |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients Azevedo, Mirela Jobim de Diabetes mellitus tipo 1 Dieta com restrição de proteínas Taxa de filtração glomerular Insulin-dependent diabetes mellitus Low-protein diet Hyperfiltration Normoalbuminuria |
title_short |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
title_full |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
title_fullStr |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
title_full_unstemmed |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
title_sort |
A short-term low-protein diet reduces glomerular filtration rate in insulin-dependent diabetes mellitus patients |
author |
Azevedo, Mirela Jobim de |
author_facet |
Azevedo, Mirela Jobim de Gross, Jorge Luiz Padilha, L.M. |
author_role |
author |
author2 |
Gross, Jorge Luiz Padilha, L.M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Azevedo, Mirela Jobim de Gross, Jorge Luiz Padilha, L.M. |
dc.subject.por.fl_str_mv |
Diabetes mellitus tipo 1 Dieta com restrição de proteínas Taxa de filtração glomerular |
topic |
Diabetes mellitus tipo 1 Dieta com restrição de proteínas Taxa de filtração glomerular Insulin-dependent diabetes mellitus Low-protein diet Hyperfiltration Normoalbuminuria |
dc.subject.eng.fl_str_mv |
Insulin-dependent diabetes mellitus Low-protein diet Hyperfiltration Normoalbuminuria |
description |
I. The effect of a 7-day low-protein diet on renal function was studied in 17 normotensive, normoalbuminuric, insulin-dependent diabetes mellitus (IDDM) patients. Glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were measured after 7 days on an isocaloric low-protein diet (0.5 g protein/kg per day). 2. Compliance was confirmed by 24-h urinary urea levels. GFR was measured after a single injection of 5Icr-EDTA and UAE by radioimmunoassay. 3. GFR was reduced by 13.8% on the low-protein diet (139.9 ±27.7 vs 120.4 ±25.1 rn1 min-I (1.73 m2)-l) (P<0.05). This effect was of the same magnitude as that obtained by others after long-term strict metabolic control. No changes were observed in UAE (5.6 ± 6.4 vs 5.7 ± 6.8 f.Lg/min) during the study. The patients were classified as hyperfiltering (N = 9; GFR = 160.3 ± 16.6 rn1 min-I (1.73 m2)-l) or normofiltering (N = 8; GFR = 117.1 ± 17.6 ml min-I (1.73 m2)-l) on the basis ofGFR, and no difference in the reduction of GFR was observed in either group. 4. The reduction in GFR is probably caused primarily by the reduction of protein intake since other factors that might influence the GFR such as glucose control and blood pressure did not change during the study. |
publishDate |
1990 |
dc.date.issued.fl_str_mv |
1990 |
dc.date.accessioned.fl_str_mv |
2022-08-19T04:45:35Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/247450 |
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0100-879X |
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000061265 |
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http://hdl.handle.net/10183/247450 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Ribeirao Preto. Vol. 23, no. 8 (1990), p. 647-654 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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