Putative target sites in synganglion for novel ixodid tick control strategies
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/254791 |
Resumo: | Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control. |
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Waldman, JéssicaKlafke, Guilherme M.Tirloni, LucasLogullo, CarlosVaz Junior, Itabajara da Silva2023-02-14T03:22:09Z20231877-959Xhttp://hdl.handle.net/10183/254791001161960Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.application/pdfengTicks and Tick-borne Diseases. Amsterdam. Vol. 14, no. 3 (May 2023), 102123, 12 p.ProteínasSingânglioCarrapatosPrevenção e controleResistência aos acaricidasAcaricideControlRhipicephalus microplusPutative target sites in synganglion for novel ixodid tick control strategiesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161960.pdf.txt001161960.pdf.txtExtracted Texttext/plain113786http://www.lume.ufrgs.br/bitstream/10183/254791/2/001161960.pdf.txt407d4c4c0299ea028cd2fe163c8ba73eMD52ORIGINAL001161960.pdfTexto completo (inglês)application/pdf1734548http://www.lume.ufrgs.br/bitstream/10183/254791/1/001161960.pdfe10e38d2c2cb236f468c5e956a5ae7aaMD5110183/2547912024-02-09 06:08:29.779141oai:www.lume.ufrgs.br:10183/254791Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-02-09T08:08:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Putative target sites in synganglion for novel ixodid tick control strategies |
title |
Putative target sites in synganglion for novel ixodid tick control strategies |
spellingShingle |
Putative target sites in synganglion for novel ixodid tick control strategies Waldman, Jéssica Proteínas Singânglio Carrapatos Prevenção e controle Resistência aos acaricidas Acaricide Control Rhipicephalus microplus |
title_short |
Putative target sites in synganglion for novel ixodid tick control strategies |
title_full |
Putative target sites in synganglion for novel ixodid tick control strategies |
title_fullStr |
Putative target sites in synganglion for novel ixodid tick control strategies |
title_full_unstemmed |
Putative target sites in synganglion for novel ixodid tick control strategies |
title_sort |
Putative target sites in synganglion for novel ixodid tick control strategies |
author |
Waldman, Jéssica |
author_facet |
Waldman, Jéssica Klafke, Guilherme M. Tirloni, Lucas Logullo, Carlos Vaz Junior, Itabajara da Silva |
author_role |
author |
author2 |
Klafke, Guilherme M. Tirloni, Lucas Logullo, Carlos Vaz Junior, Itabajara da Silva |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Waldman, Jéssica Klafke, Guilherme M. Tirloni, Lucas Logullo, Carlos Vaz Junior, Itabajara da Silva |
dc.subject.por.fl_str_mv |
Proteínas Singânglio Carrapatos Prevenção e controle Resistência aos acaricidas |
topic |
Proteínas Singânglio Carrapatos Prevenção e controle Resistência aos acaricidas Acaricide Control Rhipicephalus microplus |
dc.subject.eng.fl_str_mv |
Acaricide Control Rhipicephalus microplus |
description |
Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-02-14T03:22:09Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/254791 |
dc.identifier.issn.pt_BR.fl_str_mv |
1877-959X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001161960 |
identifier_str_mv |
1877-959X 001161960 |
url |
http://hdl.handle.net/10183/254791 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Ticks and Tick-borne Diseases. Amsterdam. Vol. 14, no. 3 (May 2023), 102123, 12 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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