Putative target sites in synganglion for novel ixodid tick control strategies

Detalhes bibliográficos
Autor(a) principal: Waldman, Jéssica
Data de Publicação: 2023
Outros Autores: Klafke, Guilherme M., Tirloni, Lucas, Logullo, Carlos, Vaz Junior, Itabajara da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/254791
Resumo: Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.
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spelling Waldman, JéssicaKlafke, Guilherme M.Tirloni, LucasLogullo, CarlosVaz Junior, Itabajara da Silva2023-02-14T03:22:09Z20231877-959Xhttp://hdl.handle.net/10183/254791001161960Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.application/pdfengTicks and Tick-borne Diseases. Amsterdam. Vol. 14, no. 3 (May 2023), 102123, 12 p.ProteínasSingânglioCarrapatosPrevenção e controleResistência aos acaricidasAcaricideControlRhipicephalus microplusPutative target sites in synganglion for novel ixodid tick control strategiesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161960.pdf.txt001161960.pdf.txtExtracted Texttext/plain113786http://www.lume.ufrgs.br/bitstream/10183/254791/2/001161960.pdf.txt407d4c4c0299ea028cd2fe163c8ba73eMD52ORIGINAL001161960.pdfTexto completo (inglês)application/pdf1734548http://www.lume.ufrgs.br/bitstream/10183/254791/1/001161960.pdfe10e38d2c2cb236f468c5e956a5ae7aaMD5110183/2547912024-02-09 06:08:29.779141oai:www.lume.ufrgs.br:10183/254791Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-02-09T08:08:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Putative target sites in synganglion for novel ixodid tick control strategies
title Putative target sites in synganglion for novel ixodid tick control strategies
spellingShingle Putative target sites in synganglion for novel ixodid tick control strategies
Waldman, Jéssica
Proteínas
Singânglio
Carrapatos
Prevenção e controle
Resistência aos acaricidas
Acaricide
Control
Rhipicephalus microplus
title_short Putative target sites in synganglion for novel ixodid tick control strategies
title_full Putative target sites in synganglion for novel ixodid tick control strategies
title_fullStr Putative target sites in synganglion for novel ixodid tick control strategies
title_full_unstemmed Putative target sites in synganglion for novel ixodid tick control strategies
title_sort Putative target sites in synganglion for novel ixodid tick control strategies
author Waldman, Jéssica
author_facet Waldman, Jéssica
Klafke, Guilherme M.
Tirloni, Lucas
Logullo, Carlos
Vaz Junior, Itabajara da Silva
author_role author
author2 Klafke, Guilherme M.
Tirloni, Lucas
Logullo, Carlos
Vaz Junior, Itabajara da Silva
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Waldman, Jéssica
Klafke, Guilherme M.
Tirloni, Lucas
Logullo, Carlos
Vaz Junior, Itabajara da Silva
dc.subject.por.fl_str_mv Proteínas
Singânglio
Carrapatos
Prevenção e controle
Resistência aos acaricidas
topic Proteínas
Singânglio
Carrapatos
Prevenção e controle
Resistência aos acaricidas
Acaricide
Control
Rhipicephalus microplus
dc.subject.eng.fl_str_mv Acaricide
Control
Rhipicephalus microplus
description Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-02-14T03:22:09Z
dc.date.issued.fl_str_mv 2023
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/254791
dc.identifier.issn.pt_BR.fl_str_mv 1877-959X
dc.identifier.nrb.pt_BR.fl_str_mv 001161960
identifier_str_mv 1877-959X
001161960
url http://hdl.handle.net/10183/254791
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Ticks and Tick-borne Diseases. Amsterdam. Vol. 14, no. 3 (May 2023), 102123, 12 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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