Treatment of hypernatremia in breastfeeding neonates : a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/163558 |
Resumo: | Background/Aims: Hypernatremic dehydration in term neonates is associated with inadequate fluid intake, usually related to insufficient lactation. The use of hypotonic fluids is appropriate to dilute serum sodium (SNa), but cerebral edema may develop when it happens abruptly. Our objective was to clarify how to correct hypernatremic dehydration properly. Methods: The following databases were searched, limited to studies published until January 31st, 2016: Clinical Trials, MEDLINE/PubMed, EMBASE, LILACS, and the Cochrane Library. We included open-label trials, nonrandomized controlled trials, or prospective and retrospective case series evaluating relevant outcomes. Information regarding the way of administering the treatment, type of fluid used, rates of complications and outcomes, as well as the rate of SNa reduction were collected. Results: Searches yielded 771 articles: 64 had the full text reviewed and 9 were included. No randomized clinical trials or systematic reviews focusing on treatment of hypernatremic dehydration and its outcomes were found. We found a scarcity of high quality studies and great methodology heterogeneity. Conclusions: More severe hypernatremia is at greater risk of causing severe adverse effects of treatment. There is no consensus about the optimal rate of SNa drop in this population, but a slower correction appears to be safer. Questions as when parenteral fluids are indicated remain unanswered. |
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Bischoff, Adrianne RahdeDornelles, Alícia DornelesCarvalho, Clarissa Gutierrez2017-06-28T02:29:23Z20172296-6870http://hdl.handle.net/10183/163558001017657Background/Aims: Hypernatremic dehydration in term neonates is associated with inadequate fluid intake, usually related to insufficient lactation. The use of hypotonic fluids is appropriate to dilute serum sodium (SNa), but cerebral edema may develop when it happens abruptly. Our objective was to clarify how to correct hypernatremic dehydration properly. Methods: The following databases were searched, limited to studies published until January 31st, 2016: Clinical Trials, MEDLINE/PubMed, EMBASE, LILACS, and the Cochrane Library. We included open-label trials, nonrandomized controlled trials, or prospective and retrospective case series evaluating relevant outcomes. Information regarding the way of administering the treatment, type of fluid used, rates of complications and outcomes, as well as the rate of SNa reduction were collected. Results: Searches yielded 771 articles: 64 had the full text reviewed and 9 were included. No randomized clinical trials or systematic reviews focusing on treatment of hypernatremic dehydration and its outcomes were found. We found a scarcity of high quality studies and great methodology heterogeneity. Conclusions: More severe hypernatremia is at greater risk of causing severe adverse effects of treatment. There is no consensus about the optimal rate of SNa drop in this population, but a slower correction appears to be safer. Questions as when parenteral fluids are indicated remain unanswered.application/pdfengBiomedicine hub. Basel. Vol. 2, no. 1 (Jan./Apr. 2017), 454980, 10 p.HipernatremiaEdema encefálicoRecém-nascidoHypernatremic dehydrationHypernatremia treatmentTerm neonatesSerum sodiumCerebral edemaBreastfeedingTreatment of hypernatremia in breastfeeding neonates : a systematic reviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001017657.pdf001017657.pdfTexto completo (inglês)application/pdf1215629http://www.lume.ufrgs.br/bitstream/10183/163558/1/001017657.pdfcf78ae0fd7250f64b91f61824e493812MD51TEXT001017657.pdf.txt001017657.pdf.txtExtracted Texttext/plain36857http://www.lume.ufrgs.br/bitstream/10183/163558/2/001017657.pdf.txt79cc42ad42d847b02b7d9e4361482b81MD52THUMBNAIL001017657.pdf.jpg001017657.pdf.jpgGenerated Thumbnailimage/jpeg1950http://www.lume.ufrgs.br/bitstream/10183/163558/3/001017657.pdf.jpg703e3128d62eda4605a5d238dea02c69MD5310183/1635582022-09-23 04:42:58.350261oai:www.lume.ufrgs.br:10183/163558Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-09-23T07:42:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
title |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
spellingShingle |
Treatment of hypernatremia in breastfeeding neonates : a systematic review Bischoff, Adrianne Rahde Hipernatremia Edema encefálico Recém-nascido Hypernatremic dehydration Hypernatremia treatment Term neonates Serum sodium Cerebral edema Breastfeeding |
title_short |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
title_full |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
title_fullStr |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
title_full_unstemmed |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
title_sort |
Treatment of hypernatremia in breastfeeding neonates : a systematic review |
author |
Bischoff, Adrianne Rahde |
author_facet |
Bischoff, Adrianne Rahde Dornelles, Alícia Dorneles Carvalho, Clarissa Gutierrez |
author_role |
author |
author2 |
Dornelles, Alícia Dorneles Carvalho, Clarissa Gutierrez |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Bischoff, Adrianne Rahde Dornelles, Alícia Dorneles Carvalho, Clarissa Gutierrez |
dc.subject.por.fl_str_mv |
Hipernatremia Edema encefálico Recém-nascido |
topic |
Hipernatremia Edema encefálico Recém-nascido Hypernatremic dehydration Hypernatremia treatment Term neonates Serum sodium Cerebral edema Breastfeeding |
dc.subject.eng.fl_str_mv |
Hypernatremic dehydration Hypernatremia treatment Term neonates Serum sodium Cerebral edema Breastfeeding |
description |
Background/Aims: Hypernatremic dehydration in term neonates is associated with inadequate fluid intake, usually related to insufficient lactation. The use of hypotonic fluids is appropriate to dilute serum sodium (SNa), but cerebral edema may develop when it happens abruptly. Our objective was to clarify how to correct hypernatremic dehydration properly. Methods: The following databases were searched, limited to studies published until January 31st, 2016: Clinical Trials, MEDLINE/PubMed, EMBASE, LILACS, and the Cochrane Library. We included open-label trials, nonrandomized controlled trials, or prospective and retrospective case series evaluating relevant outcomes. Information regarding the way of administering the treatment, type of fluid used, rates of complications and outcomes, as well as the rate of SNa reduction were collected. Results: Searches yielded 771 articles: 64 had the full text reviewed and 9 were included. No randomized clinical trials or systematic reviews focusing on treatment of hypernatremic dehydration and its outcomes were found. We found a scarcity of high quality studies and great methodology heterogeneity. Conclusions: More severe hypernatremia is at greater risk of causing severe adverse effects of treatment. There is no consensus about the optimal rate of SNa drop in this population, but a slower correction appears to be safer. Questions as when parenteral fluids are indicated remain unanswered. |
publishDate |
2017 |
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2017 |
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001017657 |
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Biomedicine hub. Basel. Vol. 2, no. 1 (Jan./Apr. 2017), 454980, 10 p. |
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