Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/194821 |
Resumo: | Background: Pre-implantation kidney biopsy is a diagnostic tool used for deciding whether to accept an expanded-criteria deceased donor graft. However, the study of histopathological lesions in renal compartments as prognostic factors for graft function and survival has led to conflicting results. Objectives: This study aimed to evaluate the presence of chronic lesions in pre-implantation kidney biopsies and correlate the findings with graft function and survival at 1, 3, and 5 years post-transplantation. Patients and Methods: Around 430 kidney biopsies from standard and expanded-criteria deceased donors were analyzed between 2006 and 2013 at the hospital Santa Casa de Porto Alegre. Lesions were graded according to the Banff criteria. The glomerular filtration rate (GFR) was calculated by the CKD-EPI equation. Graft survival was calculated by the Kaplan-Meier method. Clinical variables related to graft outcome were assessed by Cox regression analysis. Results: The decrease in graft survival and function at the analyzed periods was related to a greater degree of chronic lesions in renal compartments. Glomerulosclerosis (GS) was an independent risk factor for graft loss. Conclusions: Chronic lesions in any renal compartment should be taken into account in the clinical decision of accepting the kidney, but a greater weight should be given to GS. Kidney recipients with more than 25% GS had a less favorable outcome in our study. |
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Pêgas, Karla LaisKist, RogerKeitel, CynthiaPacheco, LarissaCambruzzi, EduardoKeitel, Elizete2019-05-31T02:45:53Z20182251-8363http://hdl.handle.net/10183/194821001089722Background: Pre-implantation kidney biopsy is a diagnostic tool used for deciding whether to accept an expanded-criteria deceased donor graft. However, the study of histopathological lesions in renal compartments as prognostic factors for graft function and survival has led to conflicting results. Objectives: This study aimed to evaluate the presence of chronic lesions in pre-implantation kidney biopsies and correlate the findings with graft function and survival at 1, 3, and 5 years post-transplantation. Patients and Methods: Around 430 kidney biopsies from standard and expanded-criteria deceased donors were analyzed between 2006 and 2013 at the hospital Santa Casa de Porto Alegre. Lesions were graded according to the Banff criteria. The glomerular filtration rate (GFR) was calculated by the CKD-EPI equation. Graft survival was calculated by the Kaplan-Meier method. Clinical variables related to graft outcome were assessed by Cox regression analysis. Results: The decrease in graft survival and function at the analyzed periods was related to a greater degree of chronic lesions in renal compartments. Glomerulosclerosis (GS) was an independent risk factor for graft loss. Conclusions: Chronic lesions in any renal compartment should be taken into account in the clinical decision of accepting the kidney, but a greater weight should be given to GS. Kidney recipients with more than 25% GS had a less favorable outcome in our study.application/pdfengJournal of nephropathology. Isfahan. Vol. 7, no. 4 (Oct. 2018), p. 248-254Sobrevivência de enxertoTransplante de rimBiópsiaRenal transplantationPre-implantation biopsyGraft survivalHistological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and functionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001089722.pdf.txt001089722.pdf.txtExtracted Texttext/plain26693http://www.lume.ufrgs.br/bitstream/10183/194821/2/001089722.pdf.txt34f1e01fbf5f001ec29c7d4e90b0c905MD52ORIGINAL001089722.pdfTexto completo (inglês)application/pdf917859http://www.lume.ufrgs.br/bitstream/10183/194821/1/001089722.pdf24bcf2adb705c21682c07c2b83082ba3MD5110183/1948212019-06-01 02:39:59.730137oai:www.lume.ufrgs.br:10183/194821Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-01T05:39:59Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
title |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
spellingShingle |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function Pêgas, Karla Lais Sobrevivência de enxerto Transplante de rim Biópsia Renal transplantation Pre-implantation biopsy Graft survival |
title_short |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
title_full |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
title_fullStr |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
title_full_unstemmed |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
title_sort |
Histological analysis of pre-transplant deceased donor renal biopsies and its association with long-term graft survival and function |
author |
Pêgas, Karla Lais |
author_facet |
Pêgas, Karla Lais Kist, Roger Keitel, Cynthia Pacheco, Larissa Cambruzzi, Eduardo Keitel, Elizete |
author_role |
author |
author2 |
Kist, Roger Keitel, Cynthia Pacheco, Larissa Cambruzzi, Eduardo Keitel, Elizete |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pêgas, Karla Lais Kist, Roger Keitel, Cynthia Pacheco, Larissa Cambruzzi, Eduardo Keitel, Elizete |
dc.subject.por.fl_str_mv |
Sobrevivência de enxerto Transplante de rim Biópsia |
topic |
Sobrevivência de enxerto Transplante de rim Biópsia Renal transplantation Pre-implantation biopsy Graft survival |
dc.subject.eng.fl_str_mv |
Renal transplantation Pre-implantation biopsy Graft survival |
description |
Background: Pre-implantation kidney biopsy is a diagnostic tool used for deciding whether to accept an expanded-criteria deceased donor graft. However, the study of histopathological lesions in renal compartments as prognostic factors for graft function and survival has led to conflicting results. Objectives: This study aimed to evaluate the presence of chronic lesions in pre-implantation kidney biopsies and correlate the findings with graft function and survival at 1, 3, and 5 years post-transplantation. Patients and Methods: Around 430 kidney biopsies from standard and expanded-criteria deceased donors were analyzed between 2006 and 2013 at the hospital Santa Casa de Porto Alegre. Lesions were graded according to the Banff criteria. The glomerular filtration rate (GFR) was calculated by the CKD-EPI equation. Graft survival was calculated by the Kaplan-Meier method. Clinical variables related to graft outcome were assessed by Cox regression analysis. Results: The decrease in graft survival and function at the analyzed periods was related to a greater degree of chronic lesions in renal compartments. Glomerulosclerosis (GS) was an independent risk factor for graft loss. Conclusions: Chronic lesions in any renal compartment should be taken into account in the clinical decision of accepting the kidney, but a greater weight should be given to GS. Kidney recipients with more than 25% GS had a less favorable outcome in our study. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-05-31T02:45:53Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://hdl.handle.net/10183/194821 |
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001089722 |
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http://hdl.handle.net/10183/194821 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of nephropathology. Isfahan. Vol. 7, no. 4 (Oct. 2018), p. 248-254 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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