Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/194152 |
Resumo: | Background Angiogenic and antiangiogenic factors are altered in pregnant women with preeclampsia (PE), but the pattern of expression of these factors in their newborns remains unknown. Objective This study aims to measure vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels in preterm neonates born to mothers with PE. Methods Neonates with birth weight < 2,000 g and gestational age 34 weeks were included and divided into the following two groups: born to mothers with PE and without PE. Blood was collected from neonates within the first 72 hours of life. VEGF and sFlt-1 levels were measured using the enzyme-linked immunosorbent assay method. Results A total of 88 neonates were included (37 born to mothers with PE and 51 born to mothers without PE), with a mean gestational age of 29.12 2.96 weeks and birth weight of 1,223.80 417.48 g. In the multivariate analysis, VEGF was 80% lower and sFlt-1 was 13.48 times higher in the group with PE. sFlt-1 concentration was higher in neonates small for gestational age (SGA) than in those appropriate for gestational age. Conclusion Higher sFlt-1 and lower VEGF levels in the group with PE, as well as higher sFlt-1 levels in SGA neonates, reflect a predominance of antiangiogenic mechanisms in PE and growth restriction. |
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Hentges, Cláudia ReginaSilveira, Rita de Cássia dos SantosProcianoy, Renato Soibelmann2019-05-11T02:37:47Z20131098-8785http://hdl.handle.net/10183/194152000978283Background Angiogenic and antiangiogenic factors are altered in pregnant women with preeclampsia (PE), but the pattern of expression of these factors in their newborns remains unknown. Objective This study aims to measure vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels in preterm neonates born to mothers with PE. Methods Neonates with birth weight < 2,000 g and gestational age 34 weeks were included and divided into the following two groups: born to mothers with PE and without PE. Blood was collected from neonates within the first 72 hours of life. VEGF and sFlt-1 levels were measured using the enzyme-linked immunosorbent assay method. Results A total of 88 neonates were included (37 born to mothers with PE and 51 born to mothers without PE), with a mean gestational age of 29.12 2.96 weeks and birth weight of 1,223.80 417.48 g. In the multivariate analysis, VEGF was 80% lower and sFlt-1 was 13.48 times higher in the group with PE. sFlt-1 concentration was higher in neonates small for gestational age (SGA) than in those appropriate for gestational age. Conclusion Higher sFlt-1 and lower VEGF levels in the group with PE, as well as higher sFlt-1 levels in SGA neonates, reflect a predominance of antiangiogenic mechanisms in PE and growth restriction.application/pdfengAmerican journal of perinatology. New York. Vol. 32, no. 12 (Oct. 2015), p. 1185-1190Recém-nascido de muito baixo pesoCrescimento e desenvolvimentoNutriçãoNutrição da gestanteAngiogenic factorsAntiangiogenic factorssFlt-1VEGFPrematurityPreeclampsiaAngiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsiaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000978283.pdf.txt000978283.pdf.txtExtracted Texttext/plain26260http://www.lume.ufrgs.br/bitstream/10183/194152/2/000978283.pdf.txtd26c0f9819911fbc4ea592fbe21dae25MD52ORIGINAL000978283.pdfTexto completo (inglês)application/pdf218183http://www.lume.ufrgs.br/bitstream/10183/194152/1/000978283.pdf0e4a80c8a000511d064cd86a4f48ecf0MD5110183/1941522023-07-09 03:36:29.840999oai:www.lume.ufrgs.br:10183/194152Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-09T06:36:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
title |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
spellingShingle |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia Hentges, Cláudia Regina Recém-nascido de muito baixo peso Crescimento e desenvolvimento Nutrição Nutrição da gestante Angiogenic factors Antiangiogenic factors sFlt-1 VEGF Prematurity Preeclampsia |
title_short |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
title_full |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
title_fullStr |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
title_full_unstemmed |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
title_sort |
Angiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsia |
author |
Hentges, Cláudia Regina |
author_facet |
Hentges, Cláudia Regina Silveira, Rita de Cássia dos Santos Procianoy, Renato Soibelmann |
author_role |
author |
author2 |
Silveira, Rita de Cássia dos Santos Procianoy, Renato Soibelmann |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Hentges, Cláudia Regina Silveira, Rita de Cássia dos Santos Procianoy, Renato Soibelmann |
dc.subject.por.fl_str_mv |
Recém-nascido de muito baixo peso Crescimento e desenvolvimento Nutrição Nutrição da gestante |
topic |
Recém-nascido de muito baixo peso Crescimento e desenvolvimento Nutrição Nutrição da gestante Angiogenic factors Antiangiogenic factors sFlt-1 VEGF Prematurity Preeclampsia |
dc.subject.eng.fl_str_mv |
Angiogenic factors Antiangiogenic factors sFlt-1 VEGF Prematurity Preeclampsia |
description |
Background Angiogenic and antiangiogenic factors are altered in pregnant women with preeclampsia (PE), but the pattern of expression of these factors in their newborns remains unknown. Objective This study aims to measure vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels in preterm neonates born to mothers with PE. Methods Neonates with birth weight < 2,000 g and gestational age 34 weeks were included and divided into the following two groups: born to mothers with PE and without PE. Blood was collected from neonates within the first 72 hours of life. VEGF and sFlt-1 levels were measured using the enzyme-linked immunosorbent assay method. Results A total of 88 neonates were included (37 born to mothers with PE and 51 born to mothers without PE), with a mean gestational age of 29.12 2.96 weeks and birth weight of 1,223.80 417.48 g. In the multivariate analysis, VEGF was 80% lower and sFlt-1 was 13.48 times higher in the group with PE. sFlt-1 concentration was higher in neonates small for gestational age (SGA) than in those appropriate for gestational age. Conclusion Higher sFlt-1 and lower VEGF levels in the group with PE, as well as higher sFlt-1 levels in SGA neonates, reflect a predominance of antiangiogenic mechanisms in PE and growth restriction. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2019-05-11T02:37:47Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/194152 |
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1098-8785 |
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000978283 |
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http://hdl.handle.net/10183/194152 |
dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
American journal of perinatology. New York. Vol. 32, no. 12 (Oct. 2015), p. 1185-1190 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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