Severity score system for progressive myelopathy : development and validation of a new clinical scale
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/87727 |
Resumo: | Progressive myelopathies can be secondary to inborn errors of metabolism (IEM) such as mucopolysaccharidosis, mucolipidosis, and adrenomyeloneuropathy. The available scale, Japanese Orthopaedic Association (JOA) score, was validated only for degenerative vertebral diseases. Our objective is to propose and validate a new scale addressing progressive myelopathies and to present validating data for JOA in these diseases. A new scale, Severity Score System for Progressive Myelopathy (SSPROM), was constructed covering motor disability, sphincter dysfunction, spasticity, and sensory losses. Inter- and intra-rater reliabilities were measured. External validation was tested by applying JOA, the Expanded Disability Status Scale (EDSS), the Barthel index, and the Osame Motor Disability Score. Thirty-eight patients, 17 with adrenomyeloneuropathy, 3 with mucopolysaccharidosis I, 3 with mucopolysaccharidosis IV, 2 with mucopolysaccharidosis VI, 2 with mucolipidosis, and 11 with human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy participated in the study. The mean ± SD SSPROM and JOA scores were 74.6 ± 11.4 and 12.4 ± 2.3, respectively. Construct validity for SSPROM (JOA: r = 0.84, P < 0.0001; EDSS: r = -0.83, P < 0.0001; Barthel: r = 0.56, P < 0.002; Osame: r = -0.94, P < 0.0001) and reliability (intra-rater: r = 0.83, P < 0.0001; inter-rater: r = 0.94, P < 0.0001) were demonstrated. The metric properties of JOA were similar to those found in SSPROM. Several clinimetric requirements were met for both SSPROM and JOA scales. Since SSPROM has a wider range, it should be useful for follow-up studies on IEM myelopathies. |
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Castilhos, Raphael Machado deBlank, DeborahNetto, Cristina Brinckmann OliveiraSouza, Carolina Fischinger Moura deFernandes, Luiz Nelson TeixeiraSchwartz, Ida Vanessa DoederleinGiugliani, RobertoJardim, Laura Bannach2014-02-26T01:51:31Z20120100-879Xhttp://hdl.handle.net/10183/87727000856369Progressive myelopathies can be secondary to inborn errors of metabolism (IEM) such as mucopolysaccharidosis, mucolipidosis, and adrenomyeloneuropathy. The available scale, Japanese Orthopaedic Association (JOA) score, was validated only for degenerative vertebral diseases. Our objective is to propose and validate a new scale addressing progressive myelopathies and to present validating data for JOA in these diseases. A new scale, Severity Score System for Progressive Myelopathy (SSPROM), was constructed covering motor disability, sphincter dysfunction, spasticity, and sensory losses. Inter- and intra-rater reliabilities were measured. External validation was tested by applying JOA, the Expanded Disability Status Scale (EDSS), the Barthel index, and the Osame Motor Disability Score. Thirty-eight patients, 17 with adrenomyeloneuropathy, 3 with mucopolysaccharidosis I, 3 with mucopolysaccharidosis IV, 2 with mucopolysaccharidosis VI, 2 with mucolipidosis, and 11 with human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy participated in the study. The mean ± SD SSPROM and JOA scores were 74.6 ± 11.4 and 12.4 ± 2.3, respectively. Construct validity for SSPROM (JOA: r = 0.84, P < 0.0001; EDSS: r = -0.83, P < 0.0001; Barthel: r = 0.56, P < 0.002; Osame: r = -0.94, P < 0.0001) and reliability (intra-rater: r = 0.83, P < 0.0001; inter-rater: r = 0.94, P < 0.0001) were demonstrated. The metric properties of JOA were similar to those found in SSPROM. Several clinimetric requirements were met for both SSPROM and JOA scales. Since SSPROM has a wider range, it should be useful for follow-up studies on IEM myelopathies.application/pdfengRevista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 45, n. 7 (July 2012), p. 565-572MucopolissacaridoseMucolipidosesJapanese Orthopaedic AssociationSeverity Score System for Progressive MyelopathyMucopolysaccharidosisMucolipidosisAdrenomyeloneuropathyProgressive myelopathiesSeverity score system for progressive myelopathy : development and validation of a new clinical scaleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000856369.pdf000856369.pdfTexto completo (inglês)application/pdf1949460http://www.lume.ufrgs.br/bitstream/10183/87727/1/000856369.pdfb159e8aa0769d4afd80d0ee902b6b058MD51TEXT000856369.pdf.txt000856369.pdf.txtExtracted Texttext/plain29093http://www.lume.ufrgs.br/bitstream/10183/87727/2/000856369.pdf.txt4bdea7cfaa5e65cbcbc604b5d4e56cdbMD52THUMBNAIL000856369.pdf.jpg000856369.pdf.jpgGenerated Thumbnailimage/jpeg2029http://www.lume.ufrgs.br/bitstream/10183/87727/3/000856369.pdf.jpg20dc112116b706f7715d68330b3727c6MD5310183/877272021-07-09 04:32:08.123069oai:www.lume.ufrgs.br:10183/87727Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:32:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
title |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
spellingShingle |
Severity score system for progressive myelopathy : development and validation of a new clinical scale Castilhos, Raphael Machado de Mucopolissacaridose Mucolipidoses Japanese Orthopaedic Association Severity Score System for Progressive Myelopathy Mucopolysaccharidosis Mucolipidosis Adrenomyeloneuropathy Progressive myelopathies |
title_short |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
title_full |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
title_fullStr |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
title_full_unstemmed |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
title_sort |
Severity score system for progressive myelopathy : development and validation of a new clinical scale |
author |
Castilhos, Raphael Machado de |
author_facet |
Castilhos, Raphael Machado de Blank, Deborah Netto, Cristina Brinckmann Oliveira Souza, Carolina Fischinger Moura de Fernandes, Luiz Nelson Teixeira Schwartz, Ida Vanessa Doederlein Giugliani, Roberto Jardim, Laura Bannach |
author_role |
author |
author2 |
Blank, Deborah Netto, Cristina Brinckmann Oliveira Souza, Carolina Fischinger Moura de Fernandes, Luiz Nelson Teixeira Schwartz, Ida Vanessa Doederlein Giugliani, Roberto Jardim, Laura Bannach |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Castilhos, Raphael Machado de Blank, Deborah Netto, Cristina Brinckmann Oliveira Souza, Carolina Fischinger Moura de Fernandes, Luiz Nelson Teixeira Schwartz, Ida Vanessa Doederlein Giugliani, Roberto Jardim, Laura Bannach |
dc.subject.por.fl_str_mv |
Mucopolissacaridose Mucolipidoses |
topic |
Mucopolissacaridose Mucolipidoses Japanese Orthopaedic Association Severity Score System for Progressive Myelopathy Mucopolysaccharidosis Mucolipidosis Adrenomyeloneuropathy Progressive myelopathies |
dc.subject.eng.fl_str_mv |
Japanese Orthopaedic Association Severity Score System for Progressive Myelopathy Mucopolysaccharidosis Mucolipidosis Adrenomyeloneuropathy Progressive myelopathies |
description |
Progressive myelopathies can be secondary to inborn errors of metabolism (IEM) such as mucopolysaccharidosis, mucolipidosis, and adrenomyeloneuropathy. The available scale, Japanese Orthopaedic Association (JOA) score, was validated only for degenerative vertebral diseases. Our objective is to propose and validate a new scale addressing progressive myelopathies and to present validating data for JOA in these diseases. A new scale, Severity Score System for Progressive Myelopathy (SSPROM), was constructed covering motor disability, sphincter dysfunction, spasticity, and sensory losses. Inter- and intra-rater reliabilities were measured. External validation was tested by applying JOA, the Expanded Disability Status Scale (EDSS), the Barthel index, and the Osame Motor Disability Score. Thirty-eight patients, 17 with adrenomyeloneuropathy, 3 with mucopolysaccharidosis I, 3 with mucopolysaccharidosis IV, 2 with mucopolysaccharidosis VI, 2 with mucolipidosis, and 11 with human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy participated in the study. The mean ± SD SSPROM and JOA scores were 74.6 ± 11.4 and 12.4 ± 2.3, respectively. Construct validity for SSPROM (JOA: r = 0.84, P < 0.0001; EDSS: r = -0.83, P < 0.0001; Barthel: r = 0.56, P < 0.002; Osame: r = -0.94, P < 0.0001) and reliability (intra-rater: r = 0.83, P < 0.0001; inter-rater: r = 0.94, P < 0.0001) were demonstrated. The metric properties of JOA were similar to those found in SSPROM. Several clinimetric requirements were met for both SSPROM and JOA scales. Since SSPROM has a wider range, it should be useful for follow-up studies on IEM myelopathies. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-02-26T01:51:31Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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0100-879X |
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Revista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 45, n. 7 (July 2012), p. 565-572 |
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