First report of chemical composition and cytotoxicity evaluation of Foraminispora rugosa basidiomata from Brazil

• Autor(a) principal: Garcia, Viviane de Oliveira
• Data de Publicação: 2022
• Outros Autores: Fronza, Marcio, Von Borowski, Rafael Gomes, Silva, Genivaldo Alves, Zimmer, Aline Rigon, Ruaro, Thais Carine, Gnoatto, Simone Cristina Baggio, Dallegrave, Alexsandro, Silveira, Rosa Mara Borges da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/274675
• topic: Citotoxicidade; Fungos; Foraminispora rugosa; Ganodermataceae; Oxylipins; Terpenoids; Tandem mass spectra

Foraminispora rugosa is a species reported from Brazil, Venezuela, French Guiana, Costa Rica and Cuba. It is a basidiomycete in the Ganodermataceae family. In this study, both chemical composition and cytotoxicity of the ethanolic extract of F. rugosa were investigated for the frst time. Results: Phylogenetic analysis confrmed the identifcation of the specimens, and the results of cytotoxicity assays showed that at concentrations of 7.8–500.0 µg/mL the ethanolic extract displayed weak cytotoxicity against the tested cell lines. Five oxylipins were identifed by ultra high performance liquid chromatography coupled with quad- rupole time-of-fight and mass spectrometry (UHPLC-QTOF–MS). Conclusions: This study provides new insights into the current knowledge of bioactive compounds produced by macrofungi, and provides data for future biological assays with relative selectivity and safety.