Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis

Detalhes bibliográficos
Autor(a) principal: Moura, Tiane Martin de
Data de Publicação: 2015
Outros Autores: Campos, Fabrício Souza, Caierão, Juliana, Roehe, Paulo Michel, D'Azevedo, Pedro Alves, Frazzon, Jeverson, Frazzon, Ana Paula Guedes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/144242
Resumo: Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
id UFRGS-2_88d18c47a1f659818faa31b5c1452775
oai_identifier_str oai:www.lume.ufrgs.br:10183/144242
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Moura, Tiane Martin deCampos, Fabrício SouzaCaierão, JulianaRoehe, Paulo MichelD'Azevedo, Pedro AlvesFrazzon, JeversonFrazzon, Ana Paula Guedes2016-08-05T02:14:58Z20150037-8682http://hdl.handle.net/10183/144242000981187Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.application/pdfengRevista da Sociedade Brasileira de Medicina Tropical. Vol. 48, n. 5 (set./out. 2015), p. 617-621Resistência à vancomicinaEnterococcus faecalisFatores de virulênciaBiofilmeVREBiofi imExpressionInfluence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000981187.pdf000981187.pdfTexto completo (inglês)application/pdf763130http://www.lume.ufrgs.br/bitstream/10183/144242/1/000981187.pdf069f7599ce8a4daabd6301669bf8f694MD51TEXT000981187.pdf.txt000981187.pdf.txtExtracted Texttext/plain19872http://www.lume.ufrgs.br/bitstream/10183/144242/2/000981187.pdf.txt2b3efd5aa58d7115c3c6e1c93b296a35MD52THUMBNAIL000981187.pdf.jpg000981187.pdf.jpgGenerated Thumbnailimage/jpeg2357http://www.lume.ufrgs.br/bitstream/10183/144242/3/000981187.pdf.jpgeb9e429292b3f947a4856297e5e5e6f6MD5310183/1442422019-01-11 04:07:59.061331oai:www.lume.ufrgs.br:10183/144242Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:07:59Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
title Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
spellingShingle Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
Moura, Tiane Martin de
Resistência à vancomicina
Enterococcus faecalis
Fatores de virulência
Biofilme
VRE
Biofi im
Expression
title_short Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
title_full Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
title_fullStr Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
title_full_unstemmed Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
title_sort Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant enterococcus faecalis
author Moura, Tiane Martin de
author_facet Moura, Tiane Martin de
Campos, Fabrício Souza
Caierão, Juliana
Roehe, Paulo Michel
D'Azevedo, Pedro Alves
Frazzon, Jeverson
Frazzon, Ana Paula Guedes
author_role author
author2 Campos, Fabrício Souza
Caierão, Juliana
Roehe, Paulo Michel
D'Azevedo, Pedro Alves
Frazzon, Jeverson
Frazzon, Ana Paula Guedes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Tiane Martin de
Campos, Fabrício Souza
Caierão, Juliana
Roehe, Paulo Michel
D'Azevedo, Pedro Alves
Frazzon, Jeverson
Frazzon, Ana Paula Guedes
dc.subject.por.fl_str_mv Resistência à vancomicina
Enterococcus faecalis
Fatores de virulência
Biofilme
topic Resistência à vancomicina
Enterococcus faecalis
Fatores de virulência
Biofilme
VRE
Biofi im
Expression
dc.subject.eng.fl_str_mv VRE
Biofi im
Expression
description Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-08-05T02:14:58Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/144242
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.nrb.pt_BR.fl_str_mv 000981187
identifier_str_mv 0037-8682
000981187
url http://hdl.handle.net/10183/144242
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical. Vol. 48, n. 5 (set./out. 2015), p. 617-621
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/144242/1/000981187.pdf
http://www.lume.ufrgs.br/bitstream/10183/144242/2/000981187.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/144242/3/000981187.pdf.jpg
bitstream.checksum.fl_str_mv 069f7599ce8a4daabd6301669bf8f694
2b3efd5aa58d7115c3c6e1c93b296a35
eb9e429292b3f947a4856297e5e5e6f6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1801224905761488896

Registros relacionados