Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/196776 |
Resumo: | Hyper activation of the neuroimmune system is strongly related to the development of neuropsychiatric disorders. Psychosocial stress has been postulated to play an important role in triggering anxiety and major depression. In preclinical models, there is mounting evidence that social defeat stress activates microglial cells in the central nervous system. This type of stress could be one of the major factors in the development of these psychopathologies. Here, we reviewed the most recent literature on social defeat and the associated immunological reactions. We focused our attention on microglial cells and kept the effect of social defeat over microglia separate from the effect of this stressor on other immune cells and the influence of peripheral immune components in priming central immune reactions. Furthermore, we considered how social defeat stress affects microglial cells and the consequent development of anxiety- and depressive-like states in preclinical studies. We highlighted evidence for the negative impact of the over-activation of the neuroimmune system, especially by the overproduction of pro-inflammatory mediators and cytotoxins. Overproduction of these molecules may cause cellular damage and loss or decreased function of neuronal activity by excessively pruning synaptic connections that ultimately contribute to the development of anxiety- and depressive-like states |
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Stein, Dirson JoãoVasconcelos, Mailton França deAlbrechet-Souza, LucasCeresér, Keila Maria MendesAlmeida, Rosa Maria Martins de2019-07-11T02:35:11Z20171662-5153http://hdl.handle.net/10183/196776001097262Hyper activation of the neuroimmune system is strongly related to the development of neuropsychiatric disorders. Psychosocial stress has been postulated to play an important role in triggering anxiety and major depression. In preclinical models, there is mounting evidence that social defeat stress activates microglial cells in the central nervous system. This type of stress could be one of the major factors in the development of these psychopathologies. Here, we reviewed the most recent literature on social defeat and the associated immunological reactions. We focused our attention on microglial cells and kept the effect of social defeat over microglia separate from the effect of this stressor on other immune cells and the influence of peripheral immune components in priming central immune reactions. Furthermore, we considered how social defeat stress affects microglial cells and the consequent development of anxiety- and depressive-like states in preclinical studies. We highlighted evidence for the negative impact of the over-activation of the neuroimmune system, especially by the overproduction of pro-inflammatory mediators and cytotoxins. Overproduction of these molecules may cause cellular damage and loss or decreased function of neuronal activity by excessively pruning synaptic connections that ultimately contribute to the development of anxiety- and depressive-like statesapplication/pdfengFrontiers in behavioral neuroscience. Lausanne. Vol. 11 (out. 2017), article 207, 10 p.MicrogliaEstresseInflamaçãoAnsiedadePsicologia experimentalMicrogliaNeuroimmunityImmune cellsPsychosocial stressNeuropsychiatric disordersInflammatory processesMicroglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviorsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001097262.pdf.txt001097262.pdf.txtExtracted Texttext/plain50348http://www.lume.ufrgs.br/bitstream/10183/196776/2/001097262.pdf.txt9a5450000e890df96d8525eb4654a060MD52ORIGINAL001097262.pdfTexto completo (inglês)application/pdf1442753http://www.lume.ufrgs.br/bitstream/10183/196776/1/001097262.pdfbb0d41bf4bc441f944a0221218cf5c54MD5110183/1967762019-07-12 02:36:04.178351oai:www.lume.ufrgs.br:10183/196776Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-07-12T05:36:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
title |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
spellingShingle |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors Stein, Dirson João Microglia Estresse Inflamação Ansiedade Psicologia experimental Microglia Neuroimmunity Immune cells Psychosocial stress Neuropsychiatric disorders Inflammatory processes |
title_short |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
title_full |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
title_fullStr |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
title_full_unstemmed |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
title_sort |
Microglial over-activation by social defeat stress contributes to anxiety and depressive-like behaviors |
author |
Stein, Dirson João |
author_facet |
Stein, Dirson João Vasconcelos, Mailton França de Albrechet-Souza, Lucas Ceresér, Keila Maria Mendes Almeida, Rosa Maria Martins de |
author_role |
author |
author2 |
Vasconcelos, Mailton França de Albrechet-Souza, Lucas Ceresér, Keila Maria Mendes Almeida, Rosa Maria Martins de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Stein, Dirson João Vasconcelos, Mailton França de Albrechet-Souza, Lucas Ceresér, Keila Maria Mendes Almeida, Rosa Maria Martins de |
dc.subject.por.fl_str_mv |
Microglia Estresse Inflamação Ansiedade Psicologia experimental |
topic |
Microglia Estresse Inflamação Ansiedade Psicologia experimental Microglia Neuroimmunity Immune cells Psychosocial stress Neuropsychiatric disorders Inflammatory processes |
dc.subject.eng.fl_str_mv |
Microglia Neuroimmunity Immune cells Psychosocial stress Neuropsychiatric disorders Inflammatory processes |
description |
Hyper activation of the neuroimmune system is strongly related to the development of neuropsychiatric disorders. Psychosocial stress has been postulated to play an important role in triggering anxiety and major depression. In preclinical models, there is mounting evidence that social defeat stress activates microglial cells in the central nervous system. This type of stress could be one of the major factors in the development of these psychopathologies. Here, we reviewed the most recent literature on social defeat and the associated immunological reactions. We focused our attention on microglial cells and kept the effect of social defeat over microglia separate from the effect of this stressor on other immune cells and the influence of peripheral immune components in priming central immune reactions. Furthermore, we considered how social defeat stress affects microglial cells and the consequent development of anxiety- and depressive-like states in preclinical studies. We highlighted evidence for the negative impact of the over-activation of the neuroimmune system, especially by the overproduction of pro-inflammatory mediators and cytotoxins. Overproduction of these molecules may cause cellular damage and loss or decreased function of neuronal activity by excessively pruning synaptic connections that ultimately contribute to the development of anxiety- and depressive-like states |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2019-07-11T02:35:11Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/196776 |
dc.identifier.issn.pt_BR.fl_str_mv |
1662-5153 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001097262 |
identifier_str_mv |
1662-5153 001097262 |
url |
http://hdl.handle.net/10183/196776 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in behavioral neuroscience. Lausanne. Vol. 11 (out. 2017), article 207, 10 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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