C-reactive protein and cognition are unrelated to leukoaraiosis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/96959 |
Resumo: | Elevated serumlevels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain.However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, : 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (: 0.012).We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis. |
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Rizzi, LiaraMarques, Fabricio CorreiaRosset, IdianeMoriguchi, Emílio HideyukiPicon, Paulo DornellesChaves, Marcia Lorena FagundesRoriz-Cruz, Matheus2014-06-28T02:07:03Z20141537-744Xhttp://hdl.handle.net/10183/96959000917141Elevated serumlevels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain.However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, : 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (: 0.012).We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.application/pdfengScientific World Journal. Newbury, Berkshire. Vol. 2014 (Jan. 2014), article ID 121679, [8] pagesProteina C-reativaLeucoaraioseCogniçãoC-reactive protein and cognition are unrelated to leukoaraiosisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000917141.pdf000917141.pdfTexto completo (inglês)application/pdf734456http://www.lume.ufrgs.br/bitstream/10183/96959/1/000917141.pdf60c6853b7d93d36da51cc5a1d610cd00MD51TEXT000917141.pdf.txt000917141.pdf.txtExtracted Texttext/plain37296http://www.lume.ufrgs.br/bitstream/10183/96959/2/000917141.pdf.txtc10b115bce11e9541fca6731ac780522MD52THUMBNAIL000917141.pdf.jpg000917141.pdf.jpgGenerated Thumbnailimage/jpeg1857http://www.lume.ufrgs.br/bitstream/10183/96959/3/000917141.pdf.jpgbe6ef6a5bfce2ed503e1a29372f29583MD5310183/969592018-10-18 08:45:56.584oai:www.lume.ufrgs.br:10183/96959Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-18T11:45:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
C-reactive protein and cognition are unrelated to leukoaraiosis |
title |
C-reactive protein and cognition are unrelated to leukoaraiosis |
spellingShingle |
C-reactive protein and cognition are unrelated to leukoaraiosis Rizzi, Liara Proteina C-reativa Leucoaraiose Cognição |
title_short |
C-reactive protein and cognition are unrelated to leukoaraiosis |
title_full |
C-reactive protein and cognition are unrelated to leukoaraiosis |
title_fullStr |
C-reactive protein and cognition are unrelated to leukoaraiosis |
title_full_unstemmed |
C-reactive protein and cognition are unrelated to leukoaraiosis |
title_sort |
C-reactive protein and cognition are unrelated to leukoaraiosis |
author |
Rizzi, Liara |
author_facet |
Rizzi, Liara Marques, Fabricio Correia Rosset, Idiane Moriguchi, Emílio Hideyuki Picon, Paulo Dornelles Chaves, Marcia Lorena Fagundes Roriz-Cruz, Matheus |
author_role |
author |
author2 |
Marques, Fabricio Correia Rosset, Idiane Moriguchi, Emílio Hideyuki Picon, Paulo Dornelles Chaves, Marcia Lorena Fagundes Roriz-Cruz, Matheus |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rizzi, Liara Marques, Fabricio Correia Rosset, Idiane Moriguchi, Emílio Hideyuki Picon, Paulo Dornelles Chaves, Marcia Lorena Fagundes Roriz-Cruz, Matheus |
dc.subject.por.fl_str_mv |
Proteina C-reativa Leucoaraiose Cognição |
topic |
Proteina C-reativa Leucoaraiose Cognição |
description |
Elevated serumlevels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain.However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, : 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (: 0.012).We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis. |
publishDate |
2014 |
dc.date.accessioned.fl_str_mv |
2014-06-28T02:07:03Z |
dc.date.issued.fl_str_mv |
2014 |
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Estrangeiro info:eu-repo/semantics/article |
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1537-744X |
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000917141 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific World Journal. Newbury, Berkshire. Vol. 2014 (Jan. 2014), article ID 121679, [8] pages |
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openAccess |
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