A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21236 |
Resumo: | Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attentiondeficit/ hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, singleblind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression Scale (CGI). We also evaluated the adverse effects of MPH-SODAS using the Barkley Side Effect Rating Scale and subject reports of drug use during the study. The sample consisted of marijuana (N = 16; 100%) and cocaine users (N = 7; 43.8%). Subjects had a significantly greater reduction in SNAP-IV and CGI scores (P < 0.001 for all analyses) during MPH-SODAS treatment compared to placebo. No significant effects for period or sequence were found in analyses with the SNAP-IV and CGI scales. There was no significant effect on drug use. MPH-SODAS was well tolerated but was associated with more severe appetite reduction than placebo (P < 0.001). MPH-SODAS was more effective than placebo in reducing ADHD symptoms in a non-abstinent outpatient sample of adolescents with comorbid SUD. Randomized clinical trials, with larger samples and SUD intervention, are recommended. |
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Szobot, Claudia MacielRohde, Luis Augusto PaimKatz, Betina StifelmanRuaro, PaulineSchaefer, ThaisWalcher, Mariana GehlenBukstein, OscarPechansky, Flavio2010-04-24T04:15:54Z20080100-879Xhttp://hdl.handle.net/10183/21236000709004Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attentiondeficit/ hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, singleblind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression Scale (CGI). We also evaluated the adverse effects of MPH-SODAS using the Barkley Side Effect Rating Scale and subject reports of drug use during the study. The sample consisted of marijuana (N = 16; 100%) and cocaine users (N = 7; 43.8%). Subjects had a significantly greater reduction in SNAP-IV and CGI scores (P < 0.001 for all analyses) during MPH-SODAS treatment compared to placebo. No significant effects for period or sequence were found in analyses with the SNAP-IV and CGI scales. There was no significant effect on drug use. MPH-SODAS was well tolerated but was associated with more severe appetite reduction than placebo (P < 0.001). MPH-SODAS was more effective than placebo in reducing ADHD symptoms in a non-abstinent outpatient sample of adolescents with comorbid SUD. Randomized clinical trials, with larger samples and SUD intervention, are recommended.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 41, n. 3 (mar. 2008), p. 250-257Transtorno do déficit de atenção com hiperatividadeMetilfenidatoTranstornos relacionados ao uso de substânciasTratamento farmacológicoAdolescenteAttention deficithyperactivity disorderMethylphenidateSubstance use disorderTreatmentAdolescentsA randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorderinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000709004.pdf.txt000709004.pdf.txtExtracted Texttext/plain33586http://www.lume.ufrgs.br/bitstream/10183/21236/2/000709004.pdf.txt33b199b45df63959dc547ad27d986427MD52ORIGINAL000709004.pdf000709004.pdfTexto completo (inglês)application/pdf546346http://www.lume.ufrgs.br/bitstream/10183/21236/1/000709004.pdfba6967ea0fc2e5c86ab13b3d257eec8dMD51THUMBNAIL000709004.pdf.jpg000709004.pdf.jpgGenerated Thumbnailimage/jpeg2067http://www.lume.ufrgs.br/bitstream/10183/21236/3/000709004.pdf.jpgba1cdb275346e8b9701d9dcb72e31a10MD5310183/212362023-09-29 03:35:04.76424oai:www.lume.ufrgs.br:10183/21236Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-29T06:35:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
title |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
spellingShingle |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder Szobot, Claudia Maciel Transtorno do déficit de atenção com hiperatividade Metilfenidato Transtornos relacionados ao uso de substâncias Tratamento farmacológico Adolescente Attention deficit hyperactivity disorder Methylphenidate Substance use disorder Treatment Adolescents |
title_short |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
title_full |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
title_fullStr |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
title_full_unstemmed |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
title_sort |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder |
author |
Szobot, Claudia Maciel |
author_facet |
Szobot, Claudia Maciel Rohde, Luis Augusto Paim Katz, Betina Stifelman Ruaro, Pauline Schaefer, Thais Walcher, Mariana Gehlen Bukstein, Oscar Pechansky, Flavio |
author_role |
author |
author2 |
Rohde, Luis Augusto Paim Katz, Betina Stifelman Ruaro, Pauline Schaefer, Thais Walcher, Mariana Gehlen Bukstein, Oscar Pechansky, Flavio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Szobot, Claudia Maciel Rohde, Luis Augusto Paim Katz, Betina Stifelman Ruaro, Pauline Schaefer, Thais Walcher, Mariana Gehlen Bukstein, Oscar Pechansky, Flavio |
dc.subject.por.fl_str_mv |
Transtorno do déficit de atenção com hiperatividade Metilfenidato Transtornos relacionados ao uso de substâncias Tratamento farmacológico Adolescente |
topic |
Transtorno do déficit de atenção com hiperatividade Metilfenidato Transtornos relacionados ao uso de substâncias Tratamento farmacológico Adolescente Attention deficit hyperactivity disorder Methylphenidate Substance use disorder Treatment Adolescents |
dc.subject.eng.fl_str_mv |
Attention deficit hyperactivity disorder Methylphenidate Substance use disorder Treatment Adolescents |
description |
Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attentiondeficit/ hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, singleblind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression Scale (CGI). We also evaluated the adverse effects of MPH-SODAS using the Barkley Side Effect Rating Scale and subject reports of drug use during the study. The sample consisted of marijuana (N = 16; 100%) and cocaine users (N = 7; 43.8%). Subjects had a significantly greater reduction in SNAP-IV and CGI scores (P < 0.001 for all analyses) during MPH-SODAS treatment compared to placebo. No significant effects for period or sequence were found in analyses with the SNAP-IV and CGI scales. There was no significant effect on drug use. MPH-SODAS was well tolerated but was associated with more severe appetite reduction than placebo (P < 0.001). MPH-SODAS was more effective than placebo in reducing ADHD symptoms in a non-abstinent outpatient sample of adolescents with comorbid SUD. Randomized clinical trials, with larger samples and SUD intervention, are recommended. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:54Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21236 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000709004 |
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0100-879X 000709004 |
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http://hdl.handle.net/10183/21236 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 41, n. 3 (mar. 2008), p. 250-257 |
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openAccess |
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