Neurodevelopmental risk factors in schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21145 |
Resumo: | The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness. |
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Lobato, Maria Inês RodriguesBelmonte-de-Abreu, Paulo SilvaKnijnik, Daniela ZippinTeruchkin, BetinaGhisolfi, Eduardo SorensenHenriques, Alexandre Annes2010-04-24T04:15:29Z20010100-879Xhttp://hdl.handle.net/10183/21145000284412The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 155-163EsquizofreniaFatores de riscoCérebroDeficiências do desenvolvimentoSchizophreniaNeurodevelopmental disorderRisk factorsNeurodevelopmental risk factors in schizophreniainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000284412.pdf000284412.pdfTexto completo (inglês)application/pdf102292http://www.lume.ufrgs.br/bitstream/10183/21145/1/000284412.pdf4564ed513190faf412846630aac771a8MD51TEXT000284412.pdf.txt000284412.pdf.txtExtracted Texttext/plain37115http://www.lume.ufrgs.br/bitstream/10183/21145/2/000284412.pdf.txt269cff06174ed00bfd5d7e18dae914ddMD52THUMBNAIL000284412.pdf.jpg000284412.pdf.jpgGenerated Thumbnailimage/jpeg1636http://www.lume.ufrgs.br/bitstream/10183/21145/3/000284412.pdf.jpg020fd88cde6c7ce2014d14a83c2d2324MD5310183/211452023-06-16 03:31:27.038181oai:www.lume.ufrgs.br:10183/21145Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-16T06:31:27Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Neurodevelopmental risk factors in schizophrenia |
title |
Neurodevelopmental risk factors in schizophrenia |
spellingShingle |
Neurodevelopmental risk factors in schizophrenia Lobato, Maria Inês Rodrigues Esquizofrenia Fatores de risco Cérebro Deficiências do desenvolvimento Schizophrenia Neurodevelopmental disorder Risk factors |
title_short |
Neurodevelopmental risk factors in schizophrenia |
title_full |
Neurodevelopmental risk factors in schizophrenia |
title_fullStr |
Neurodevelopmental risk factors in schizophrenia |
title_full_unstemmed |
Neurodevelopmental risk factors in schizophrenia |
title_sort |
Neurodevelopmental risk factors in schizophrenia |
author |
Lobato, Maria Inês Rodrigues |
author_facet |
Lobato, Maria Inês Rodrigues Belmonte-de-Abreu, Paulo Silva Knijnik, Daniela Zippin Teruchkin, Betina Ghisolfi, Eduardo Sorensen Henriques, Alexandre Annes |
author_role |
author |
author2 |
Belmonte-de-Abreu, Paulo Silva Knijnik, Daniela Zippin Teruchkin, Betina Ghisolfi, Eduardo Sorensen Henriques, Alexandre Annes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lobato, Maria Inês Rodrigues Belmonte-de-Abreu, Paulo Silva Knijnik, Daniela Zippin Teruchkin, Betina Ghisolfi, Eduardo Sorensen Henriques, Alexandre Annes |
dc.subject.por.fl_str_mv |
Esquizofrenia Fatores de risco Cérebro Deficiências do desenvolvimento |
topic |
Esquizofrenia Fatores de risco Cérebro Deficiências do desenvolvimento Schizophrenia Neurodevelopmental disorder Risk factors |
dc.subject.eng.fl_str_mv |
Schizophrenia Neurodevelopmental disorder Risk factors |
description |
The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:29Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21145 |
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0100-879X |
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000284412 |
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0100-879X 000284412 |
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http://hdl.handle.net/10183/21145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 155-163 |
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openAccess |
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