Role of estrogen in thyroid function and growth regulation

Detalhes bibliográficos
Autor(a) principal: Santin, Ana Paula
Data de Publicação: 2011
Outros Autores: Furlanetto, Tania Weber
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/189559
Resumo: Thyroid diseases aremore prevalent in women, particularly between puberty andmenopause. It is wellknown that estrogen (E) has indirect effects on the thyroid economy. Direct effects of this steroid hormone on thyroid cells have been described more recently; so, the aim of the present paper was to review the evidences of these effects on thyroid function and growth regulation, and its mechanisms. The expression and ratios of the two E receptors, α and β, that mediate the genomic effects of E on normal and abnormal thyroid tissue were also reviewed, as well as nongenomic, distinct molecular pathways. Several evidences support the hypothesis that E has a direct role in thyroid follicular cells; understanding its influence on the growth and function of the thyroid in normal and abnormal conditions can potentially provide new targets for the treatment of thyroid diseases.
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spelling Santin, Ana PaulaFurlanetto, Tania Weber2019-03-26T04:08:06Z20112090-8067http://hdl.handle.net/10183/189559000787521Thyroid diseases aremore prevalent in women, particularly between puberty andmenopause. It is wellknown that estrogen (E) has indirect effects on the thyroid economy. Direct effects of this steroid hormone on thyroid cells have been described more recently; so, the aim of the present paper was to review the evidences of these effects on thyroid function and growth regulation, and its mechanisms. The expression and ratios of the two E receptors, α and β, that mediate the genomic effects of E on normal and abnormal thyroid tissue were also reviewed, as well as nongenomic, distinct molecular pathways. Several evidences support the hypothesis that E has a direct role in thyroid follicular cells; understanding its influence on the growth and function of the thyroid in normal and abnormal conditions can potentially provide new targets for the treatment of thyroid diseases.application/pdfengJournal of Thyroid Research. [New York]. Vol. 2011 (2011), 7 p.Doenças da glândula tireóideEstrogêniosRole of estrogen in thyroid function and growth regulationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000787521.pdf.txt000787521.pdf.txtExtracted Texttext/plain34773http://www.lume.ufrgs.br/bitstream/10183/189559/2/000787521.pdf.txtef66945bd430a545174beb6348fbca5fMD52ORIGINAL000787521.pdfTexto completo (inglês)application/pdf1226179http://www.lume.ufrgs.br/bitstream/10183/189559/1/000787521.pdf5eb023636575ea21d5d51129ed2bf084MD5110183/1895592019-03-28 04:09:37.29841oai:www.lume.ufrgs.br:10183/189559Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-03-28T07:09:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Role of estrogen in thyroid function and growth regulation
title Role of estrogen in thyroid function and growth regulation
spellingShingle Role of estrogen in thyroid function and growth regulation
Santin, Ana Paula
Doenças da glândula tireóide
Estrogênios
title_short Role of estrogen in thyroid function and growth regulation
title_full Role of estrogen in thyroid function and growth regulation
title_fullStr Role of estrogen in thyroid function and growth regulation
title_full_unstemmed Role of estrogen in thyroid function and growth regulation
title_sort Role of estrogen in thyroid function and growth regulation
author Santin, Ana Paula
author_facet Santin, Ana Paula
Furlanetto, Tania Weber
author_role author
author2 Furlanetto, Tania Weber
author2_role author
dc.contributor.author.fl_str_mv Santin, Ana Paula
Furlanetto, Tania Weber
dc.subject.por.fl_str_mv Doenças da glândula tireóide
Estrogênios
topic Doenças da glândula tireóide
Estrogênios
description Thyroid diseases aremore prevalent in women, particularly between puberty andmenopause. It is wellknown that estrogen (E) has indirect effects on the thyroid economy. Direct effects of this steroid hormone on thyroid cells have been described more recently; so, the aim of the present paper was to review the evidences of these effects on thyroid function and growth regulation, and its mechanisms. The expression and ratios of the two E receptors, α and β, that mediate the genomic effects of E on normal and abnormal thyroid tissue were also reviewed, as well as nongenomic, distinct molecular pathways. Several evidences support the hypothesis that E has a direct role in thyroid follicular cells; understanding its influence on the growth and function of the thyroid in normal and abnormal conditions can potentially provide new targets for the treatment of thyroid diseases.
publishDate 2011
dc.date.issued.fl_str_mv 2011
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dc.relation.ispartof.pt_BR.fl_str_mv Journal of Thyroid Research. [New York]. Vol. 2011 (2011), 7 p.
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